The Open Neurology Journal,
Journal Year:
2024,
Volume and Issue:
18(1)
Published: Sept. 30, 2024
Obesity
is
a
major
public
health
challenge
and
results
from
the
complex
interaction
of
many
etiopathogenetic
factors.
However,
food-related
hedonic
stimuli
poor
inhibitory
control
often
appear
to
be
specific
maintenance
factors,
conventional
treatments
are
sometimes
ineffective.
Transcranial
magnetic
stimulation
emerging
as
promising
treatment
option.
Targeting
brain
regions,
such
dorsolateral
prefrontal
cortex,
was
found
effective
in
modulating
acute
food
craving
improving
cognitive
control.
This
review
traces
evolution
development
transcranial
presents
recent
randomized
clinical
trials
conducted
obese
subjects.
These
suggest
that
repetitive
deep
may
reducing
body
weight,
BMI
cravings.
The
neural
circuits
involved
underlying
mechanisms
action
this
neurostimulation
technique
also
reviewed.
Finally,
outstanding
questions
future
research
directions
identified
further
understand
develop
therapy.
Biology,
Journal Year:
2024,
Volume and Issue:
13(11), P. 851 - 851
Published: Oct. 22, 2024
Nociceptors
are
receptors
that
detect
injurious
stimuli
and
necessary
to
convey
such
information
from
the
periphery
central
nervous
system.
While
nociception
has
been
extensively
studied
in
various
taxa,
there
is
relatively
little
electrophysiological
evidence
for
existence
of
nociceptors
decapod
crustaceans.
This
study
investigated
putative
nociceptive
responses
shore
crabs,
specifically
their
response
mechanical
noxious
chemical
stimuli.
Extracellular
multi-unit
recordings
were
conducted
anterior
ganglion
circumesophageal
connective
ganglia
assess
responses.
Soft
tissues
at
joints
chelae,
antennae,
walking
legs
stimulated
using
acetic
acid
(noxious
stimulus)
von
Frey
hairs
(mechanical
stimulus),
while
nearby
activity
was
recorded.
The
results
indicate
tested
areas,
with
eliciting
shorter,
more
intense
neural
compared
acid.
Although
triggered
all
antennae
antennules
did
not
respond
Though
we
acknowledge
challenges
conducting
vivo
recordings,
future
research
should
focus
on
further
characterizing
nociceptor
because
suggest
presence
nociceptors.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(17), P. 3015 - 3015
Published: Aug. 29, 2024
Advancements
in
understanding
pain
physiopathology
have
historically
challenged
animals'
absence
of
senses.
Studies
demonstrated
that
animals
comparable
neural
pathways,
suggesting
cats
and
dogs
likely
experience
similarly
to
humans.
Understanding
brain
circuits
for
effective
control
has
been
crucial
adjusting
management
the
patient's
individual
responses
current
condition.
The
refinement
analgesic
strategies
is
necessary
better
cater
demands.
Cancer
searches
ascertain
protocols
enhance
patient
well-being
by
minimizing
or
abolishing
reducing
its
impact
on
immune
system
cancer
cells.
Due
their
ability
reduce
nerve
sensitivity,
opioids
are
mainstay
managing
moderate
severe
acute
pain;
however,
despite
association
with
tumor
progression,
specific
opioid
agents
immune-protective
properties
considered
safe
alternatives
analgesia
patients.
Clinical Pharmacology in Drug Development,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 5, 2024
Abstract
This
single‐center,
randomized,
open,
two‐preparation,
single‐dose,
two‐period,
self‐crossover
trial
aimed
to
assess
the
bioequivalence
and
safety
of
test
(T)
preparation
compared
reference
(R)
following
intravenous
injection
in
healthy
subjects
under
fasting
conditions.
Twenty‐four
were
enrolled
study
randomly
divided
into
two
groups
at
a
1:1
ratio
administered
once
per
period,
with
an
8‐day
washout
period.
During
each
serum
drug
concentrations
detected
for
pharmacokinetic
analysis
adverse
events
recorded
analysis.
The
90%
confidence
intervals
geometric
mean
ratios
(T:R)
maximum
concentration,
area
concentration‐time
curve
from
time
zero
last
measurable
infinite
fell
within
predefined
range
80%–125%,
indicating
between
T
R
Additionally,
four
(16.7%)
experienced
five
instances
group,
while
(21.7%)
group.
indicated
potential
products
conditions,
based
on
profile.
The Open Neurology Journal,
Journal Year:
2024,
Volume and Issue:
18(1)
Published: Sept. 30, 2024
Obesity
is
a
major
public
health
challenge
and
results
from
the
complex
interaction
of
many
etiopathogenetic
factors.
However,
food-related
hedonic
stimuli
poor
inhibitory
control
often
appear
to
be
specific
maintenance
factors,
conventional
treatments
are
sometimes
ineffective.
Transcranial
magnetic
stimulation
emerging
as
promising
treatment
option.
Targeting
brain
regions,
such
dorsolateral
prefrontal
cortex,
was
found
effective
in
modulating
acute
food
craving
improving
cognitive
control.
This
review
traces
evolution
development
transcranial
presents
recent
randomized
clinical
trials
conducted
obese
subjects.
These
suggest
that
repetitive
deep
may
reducing
body
weight,
BMI
cravings.
The
neural
circuits
involved
underlying
mechanisms
action
this
neurostimulation
technique
also
reviewed.
Finally,
outstanding
questions
future
research
directions
identified
further
understand
develop
therapy.
