Efficacy and safety of fecal microbiota transplantation for chronic insomnia in adults: a real world study

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 21, 2023

Objective To assess the efficacy and safety of fecal microbiota transplantation (FMT) for adult chronic insomnia. Methods Patients treated with FMT diseases were divided into insomnia non-insomnia group. The primary endpoint was 4 weeks after treatment, secondary endpoints included impacts on anxiety, depression, health-related quality life, gut microbiota, adverse events associated FMT. Insomnia Severity Index (ISI) Pittsburgh Sleep Quality (PSQI) utilized to insomnia, self-rating anxiety/depression scale [Zung Self-Rating Anxiety Scale (SAS), Zung Depression (SDS)] employed evaluate anxiety depression. life evaluated by SF-36. 16S rRNA sequencing analyze correlation analysis performed. Results Forty patients met inclusion criteria seven excluded. 33 enrolled stratified group ( N = 17) 16). Compared baseline, significantly ameliorated ISI (17.31 ± 5.12 vs. 5.38 5.99), PSQI (14.56 2.13 6.63 4.67), SAS (54.25 8.90 43.68 10.64) SDS (57.43 10.96 50.68 15.27) score patients. 76.47% (13/17) achieved endpoints. In patients, relative abundance Eggerthella marked enhanced at while Lactobacillus, Bifidobacterium, Turicibacter, Anaerostipes , Eisenbergiella increased latter positive correlated Encouragingly, also improved sleep Conclusion may potentially serve as a distinctive genus maybe novel treatment option adults provide an alternative traditional treatments effects augmentation probiotics, such Bifidobacterium Lactobacillus Turicibacter Fusobacterium .

Language: Английский

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Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology

Medicina, Journal Year: 2023, Volume and Issue: 59(12), P. 2056 - 2056

Published: Nov. 21, 2023

In the last few years, vitamin D functions have been studied progressively, and along with their main role in regulating calcium homeostasis, potential function nervous system link between different psychiatric disorders deficiency revealed. The discovery of receptors multiple brain structures, like hippocampus, led to hypothesis that could be responsible for treatment resistance diseases. aim this study was analyze current knowledge literature regarding among individuals afflicted assess therapeutic benefits supplementation. A systematic search conducted on PubMed database articles published five years (2016–2022) English, focusing human subjects. Results show has implications numerous disorders, affecting mood behavior through its influence neurotransmitter release, neurotrophic factors, neuroprotection. It also plays a modulating inflammation, which is often elevated disorders. conclusion, prevalent far-reaching mental health. This review underscores importance exploring supplementation highlights need further research complex field.

Language: Английский

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Calcium channel blockers and mental health: a comprehensive meta-analysis of psychiatric adverse events in double-blind randomized controlled trials

Journal of Hypertension, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Objective: L-type calcium channel blockers (CCBs) are pivotal in managing cardiovascular disorders, such as hypertension and angina pectoris. Their action on channels, which not only integral to function but also present the brain, prompts questions about potential effects mental health. While previous cohort studies explored this association with mixed results, our study aims build upon these findings by systematically investigating psychiatric adverse events (PAEs) reported double-blind randomized controlled trials (RCTs). Methods: A systematic search identified RCTs reporting frequencies of PAEs during CCB therapy across different indications. Separate meta-analyses were conducted for dihydropyridine (DHP) nondihydropyridine (non-DHP) CCBs against placebo active controls. This was registered INPLASY (INPLASY202480075). Results: In 187 studies, encompassing 28,201 patients exposed CCBs, several reported, most common being depression, insomnia, somnolence, agitation. Meta-analyses revealed no significant difference PAE occurrence vs. placebo, β-blockers, renin-angiotensin system blockers, thiazide/thiazide-like diuretics (all P > 0.05). Restricting analyses DHP linked lower risks depression insomnia compared [odds ratio (OR) 0.84, confidence interval (CI) 0.70–1.00 OR 0.38, CI 0.15–0.99, both = 0.05); however, results may be artifacts should interpreted caution. Conclusion: Concerns negative health appear unwarranted deter clinicians from prescribing them when indicated. detected signal towards positive benefits warrants further investigation.

Language: Английский

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Sleep Disturbances in Generalized Anxiety Disorder: The Central Role of Insomnia

Sleep Medicine, Journal Year: 2025, Volume and Issue: 132, P. 106545 - 106545

Published: April 29, 2025

Language: Английский

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Efficacy and exploratory analysis of potential mechanisms of stellate ganglion block in alleviating sleep disturbance in generalized anxiety disorder: a randomized controlled trial excluding comorbid depression

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: May 7, 2025

To investigate the efficacy and mechanisms of stellate ganglion block (SGB) in treating generalized anxiety disorder (GAD) with sleep disturbance, excluding patients comorbid depression. This double-blind randomized controlled trial (RCT) enrolled 128 GAD (Hamilton Anxiety Scale [HAMA] > 14, Generalized Disorder 7-item [GAD-7] ≥ 5) disturbance (Pittsburgh Sleep Quality Index [PSQI] 15), to receive SGB (n = 64, 4 ultrasound-guided 1% lidocaine injections) or conventional treatment cognitive behavioral therapy [CBT] + estazolam 1-2 mg/day). Outcomes included (HAMA), depression Depression [HAMD]), quality (PSQI), polysomnography (PSG), neurotransmitter levels (norepinephrine [NE], serotonin [5-HT], neuropeptide Y [NPY]). After weeks, demonstrated higher (98.4% vs. 89.1%, p 0.028) greater reductions HAMA (9.36 ± 2.34 11.87 2.71, < 0.001) HAMD scores (6.87 2.01 8.09 2.04, 0.001). PSQI improved significantly group (5.74 1.64 8.03 1.86, 0.001), increased total time (TST) (429.76 33.22 391.13 30.76 min, efficiency (90.23 13.29% 86.34 12.84%, Neurotransmitter analysis showed reduced NE (289.43 51.68 253.78 57.12 pg./mL, 0.05) 5-HT (138.56 19.73 124.93 18.44 ng/mL, NPY (453.21 73.41 402.34 68.12 0.05). Adverse events were comparable (6.25% 3.13%, 0.403). effectively improves symptoms without depression, potentially via modulation NE, 5-HT, pathways. The exclusion psychiatric comorbidities enhances specificity these findings.

Language: Английский

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ITPR2 Mediated Calcium Homeostasis in Oligodendrocytes is Essential for Myelination and Involved in Depressive‐Like Behavior in Adolescent Mice

Advanced Science, Journal Year: 2024, Volume and Issue: 11(20)

Published: March 13, 2024

Abstract Ca 2+ signaling is essential for oligodendrocyte (OL) development and myelin formation. Inositol 1,4,5‐trisphosphate receptor type 2 (ITPR2) an endoplasmic reticulum calcium channel shows stage‐dependent high levels in postmitotic precursor cells (OPCs). The role potential mechanism of ITPR2 OLs remain unclear. In this study, it revealed that loss Itpr2 disturbs homeostasis inhibits myelination adolescent mice. Animals with OL‐specific deletion exhibit anxiety/depressive‐like behaviors manifest interrupted OPC proliferation, leading to fewer mature the brain. Detailed transcriptome profiling signal pathway analysis suggest MAPK/ERK‐CDK6/cyclin D1 axis underlies interfered cell cycle progression ablated OPCs. Besides, blocking MAPK/ERK significantly improves delayed differentiation mutant. Notably, resting [Ca ] i increased OPCs, elevation several plasma channels. Antagonists against these channels can normalize level enhance lineage Itpr2‐ Together, findings reveal novel insights manipulating developmental transition from OPCs pre‐OLs; additionally, involvement OLs‐originated depressive provides new therapeutic strategies alleviate myelin‐associated psychiatric disorders.

Language: Английский

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Risk factors affecting the sleep quality of patients on dialysis: A single-center cross-sectional study

Medicine, Journal Year: 2024, Volume and Issue: 103(13), P. e37577 - e37577

Published: March 29, 2024

Sleep quality is among the common complication in patients on dialysis and serious affect their health of life; however, other associated risk factors are unclear. This study aimed to investigate affecting sleep dialysis. Data were collected from 260 who met inclusion criteria at out hospital May 2023 October 2023. Questionnaires completed by patients, biochemical indicators obtained past medical records. Univariate multifactor analyses used find influencing Simple linear regression results showed that female, type kidney primary disease, high systolic blood pressure (SBP), pruritus, pruritus frequency, restless legs syndrome (RLS), anxiety, depression with poor quality. Blood parameters low sodium calcium levels ferritin Multiple statistics RLS, SBP, depression, chronic nephritis syndrome, mood. Future development individual nursing targeted therapies key improving

Language: Английский

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Prenatal exposure to per- and polyfluoroalkyl substances and infant sleep disturbance: A prospective cohort study

Environment International, Journal Year: 2023, Volume and Issue: 178, P. 108070 - 108070

Published: June 28, 2023

Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may adversely affect fetal brain development, yet no study has investigated the potential association between prenatal PFAS infant sleep.To explore associations of with sleep disturbances during first year life in a prospective cohort study.We recruited 4127 pregnant women from Shanghai Birth Cohort (SBC) followed their children birth 12 months old. A total 2366 infants were included 6-month analyses, 2466 12-month analyses. Ten quantified blood serum collected trimester. Sleep quality was measured using Brief Infant Questionnaire. We used multiple linear regression multinomial logistic estimate individual effects on outcomes. utilized quantile-based g-computation model determine joint mixture Additionally, generalized estimating equation (GEE) models performed examine longitudinal pregnancy.In aged 6 months, perfluorooctane sulfonate perfluoroheptanoic acid associated more than 2-fold risk parent-reported problems as severe. Perfluorodecanoic an increased often or almost always snoring one-year-old (relative ratios, 1.79; 95% CI, 1.12-2.86). mixtures positively nighttime awakenings both among (β, 0.11; 0.04-0.19) 0.05-0.18). longer latency, awakenings, nocturnal wakefulness hours, snoring, earlier sleep-onset time 6-12 according GEE models.Our suggests that increase disturbance infants.

Language: Английский

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Per-and polyfluoroalkyl substances and disrupted sleep: mediating roles of proteins

Environmental Advances, Journal Year: 2024, Volume and Issue: 17, P. 100585 - 100585

Published: Sept. 17, 2024

Language: Английский

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Generalized Anxiety: Linking in Vitamin D

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25

Published: Jan. 1, 2024

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