Targeting Arachidonic Acid Pathway with Natural Ingredients from Traditional Chinese Medicine for Cancer Prevention and Therapy DOI Creative Commons
Xiuming Li, Jiahui Yu, Yajie Dong

et al.

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(12)

Published: Dec. 1, 2024

In the process of cancer transformation, arachidonic acid (AA) serves as an important metabolic pathway, contributing to production carcinogens by participating in enzyme processes, like phospholipase A2, cyclooxygenases, cytochrome P450, and lipoxygenases. Chemopreventive drugs for various cancers have been developed from natural products that inhibit AA pathway. Moreover, different monomers components traditional Chinese medicine (TCM) are widely suggested be effective on preventing treating chemically. The present work focused analyzed therapeutic methods ingredients TCM, targeting pathways three enzymes within Additionally, we summarized substantial effect TCM effectively inhibiting tumors regulating this

Language: Английский

Trends, seasonal variations and forecasting of chronic respiratory disease morbidity in charcoal producing areas, northwest Ethiopia: time series analysis DOI Creative Commons

Mulugeta Tesfa,

Achenef Motbainor, Muluken Azage

et al.

Frontiers in Epidemiology, Journal Year: 2025, Volume and Issue: 4

Published: Jan. 15, 2025

This study analyzed the trend, seasonal variations and forecasting of chronic respiratory disease morbidity in charcoal producing areas, northwest Ethiopia, aiming to provide evidences planning, designing strategies, decision-makings for preparedness resource allocation prevent CRD reduce public health burden future. The variation, were estimated using data collected from three zones Amhara region annual reports DHIS2 records. Smoothing decomposition analysis was employed demonstrate trend component CRD. ARIMA (2, 1, 2) (0, 0, 0) model used forecast morbidity. model's fitness checked based on Bayesian information criteria. stationarity assessed with a line chart statistically Ljung-Box Q-test. SPSS version 27 utilized statistical analysis. rate has shown an increasing both sexes over seven-year period among people aged 15 years older. Seasonal variation observed. smoothing depicted that attributed 44.47% 19.16% excess cases between September November, June August, respectively. A substantial difference noted, highest observed Awi zone. Forecasting revealed CRD-related will continue increase 2020 2030. 2013 2019. observed, peak November. next ten (2020-2030). Therefore, this could potentially play groundbreaking role. Further is warranted understand risk factors facility readiness through further understanding seasonality future trends.

Language: Английский

Citations

0

Computational intelligence techniques for achieving sustainable development goals in female cancer care DOI Creative Commons
Sarad Pawar Naik Bukke, Rajasekhar Komarla Kumarachari,

Eashwar Sai Komarla Rajasekhar

et al.

Discover Sustainability, Journal Year: 2024, Volume and Issue: 5(1)

Published: Nov. 11, 2024

This narrative review explores the intersection of computational intelligence (CI) techniques and Sustainable Development Goals (SDGs) in context female cancer patients. With increasing prevalence among women worldwide, there is a pressing need to integrate advanced methods enhance diagnosis, treatment, management. highlights various CI methods, including artificial intelligence, machine learning data science, examines their contributions achieving specific SDGs like health well-being (SDG 3), gender parity 5), reduced disparity 10). Additionally, considers impact on other relevant SDGs, such as poverty eradication 1), quality education 4), economic growth decent work 8), innovation infrastructure 9), global partnerships 17). The paper discusses current state applications care, identifies challenges, proposes future directions for research practice.

Language: Английский

Citations

1

Quality of Data in Population-Based Cancer Registry and its Implications for Cancer Control: A Cross-Sectional Study in Northern Tanzania DOI Creative Commons
Julius Pius Alloyce, Maryam Amour, Stella E. Mushy

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 14, 2024

Abstract Background: Cancer remains a significant global health challenge, especially in low-resource settings where limited data obstructs effective control measures. Reliable cancer registries are essential tools for collecting, managing, and analyzing cancer-related data. In Tanzania, as many other sub-Saharan African countries, the need accurate timely is critical informed decision-making. This study assesses quality of population-based registry Tanzania to improve efforts. Methodology: adopted descriptive cross-sectional design analyze 9617 records patients database (Canreg5) from 2018 2022. Data analysis done using Stata 17.0 IARC validity check software. The percentage complete, valid, was computed compared with required target. Comparability age-standardized rates (ASR) percentages morphologically verified (MV%) against standards Africa. Results: defined period 2022, total 9,617 were included final analysis. found high indicators: completeness at 94% mandatory variables, 76%, timeliness 93%, comparability Africa 60%. However, variations noticed cases (MV). For findings, mouth pharynx had lower males (5.7) females (3.4) but morphological verification rates. Esophageal significantly higher ASR (22.0) (6.1), moderate Stomach Colon, rectum, anus comparable Conclusion: site optimal, proportion completeness, timeliness, comparability, suboptimal data, particularly date format, unlike combinations that highlight continuous monitoring checks. While vital, challenges like missing invalid persist, necessitating reinforced protocols validation

Language: Английский

Citations

0

Prevalence and associated factors of cancer-related fatigue among adult patients with cancer attending oncology units: an institution-based cross-sectional study design in the Amhara region, Ethiopia, 2022 DOI Creative Commons

Gebreeyesus Abera Zeleke,

Workie Zemene Worku, Desalegn Getachew Ayele

et al.

BMJ Public Health, Journal Year: 2024, Volume and Issue: 2(2), P. e000884 - e000884

Published: Aug. 1, 2024

Introduction Cancer-related fatigue (CRF) continues to be a common problem among most patients with cancer. It is subjective feeling of tiredness, weakness or lack energy. CRF has significant impact on social interactions, everyday activities and the general quality life cancer worldwide. However, little known about in Ethiopia as well current study area. Therefore, aim this was assess prevalence associated factors adult attending oncology units at comprehensive specialised hospitals Amhara regional state Ethiopia. Methods An institution-based cross-sectional conducted undergoing treatment. A systematic random sampling technique employed select participants. interviewer-administered questionnaire participants’ medical charts were used collect data. The consisted eight subsections, including sociodemographic characteristics, behavioural Brief Fatigue Inventory, Performance Status Scale, Oslo Social Support Status, Hospital Anxiety Depression Pittsburgh Sleep Quality Index, clinical factors. data entered into EpiData V.4.6 exported SPSS V.26 for analysis. characteristics compiled using descriptive statics. Bivariable multivariable logistic regressions identify associations between dependent independent variables. Variables value p<0.05 considered statistically significant. Result total 326 randomly selected cancer, treatment, participated study; response rate 94%. found 63.93% (95% CI 58.5% 69.25%). (adjusted OR (AOR) 1.975, 95% 1.009 3.865), poor sleep (AOR 3.309, 1.057 10.345), performance status 1.983, 1.176 4.70), stage 3.242, 1.016 10.342) admitted 2.047, 1.122 3.734) CRF. Conclusion recommendation high. Stage quality, status, depression hospital admission results show that healthcare providers should focus risk through early screening management.

Language: Английский

Citations

0

Targeting Arachidonic Acid Pathway with Natural Ingredients from Traditional Chinese Medicine for Cancer Prevention and Therapy DOI Creative Commons
Xiuming Li, Jiahui Yu, Yajie Dong

et al.

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(12)

Published: Dec. 1, 2024

In the process of cancer transformation, arachidonic acid (AA) serves as an important metabolic pathway, contributing to production carcinogens by participating in enzyme processes, like phospholipase A2, cyclooxygenases, cytochrome P450, and lipoxygenases. Chemopreventive drugs for various cancers have been developed from natural products that inhibit AA pathway. Moreover, different monomers components traditional Chinese medicine (TCM) are widely suggested be effective on preventing treating chemically. The present work focused analyzed therapeutic methods ingredients TCM, targeting pathways three enzymes within Additionally, we summarized substantial effect TCM effectively inhibiting tumors regulating this

Language: Английский

Citations

0