Comparative Assessment of Antibiotics and Probiotics: Adjuvants in Nonsurgical Periodontal Treatment for Smokers With Generalized Periodontitis

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Introduction Humankind is suffering from the misuse and overuse of antibiotics, leading to antibiotic resistance. At this point, probiotics, if found effective, can lead a better future. Probiotics are nothing but colony living-friendly bacteria. Lactobacillus reuteri essential for use as probiotic among many healthy This study aims compare effectiveness probiotics in periodontal treatment. Methods One hundred smokers diagnosed with chronic generalized periodontitis were randomly assigned into two groups. Group A received seven-day course amoxicillin 500 mg three day metronidazole twice daily, followed by 30 days while B placebo seven L. (2×10⁸ CFU daily). Periodontal parameters, including plaque index (PI), gingival (GI), probing depth (PD), attachment loss (AL), bleeding on (BOP), utilized asses at baseline, month one, one. Baseline differences adjusted using estimating equation (GEE) model. Results three, (probiotics) showed significantly lower PI (0.52±0.49 vs. 0.88±0.52, p<0.001) 23% greater reduction PD (p=0.004) compared (antibiotics + probiotics). These findings highlight alone improving health smokers. Conclusions Both groups equal health. Hence, should be preferred over antibiotics.

Language: Английский

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Evaluation of NETosis (Neutrophil Extracellular Traps) biomarkers in smokers and nonsmokers periodontitis patients

F1000Research, Journal Year: 2025, Volume and Issue: 13, P. 907 - 907

Published: April 7, 2025

Background To evaluate the NETosis biomarkers citrullinated histone H3 (citH3), neutrophil elastase (ELA), calprotectin (CALPRO), and myeloperoxidase (MPO) as indicators of inflammation in severe stages periodontitis III IV both (smokers nonsmokers) patients, to determine correlation between clinical periodontal parameters. Methods This study recruited male subjects with an age range (20-60) years; 60 were stage 30 cigarette smoker, nonsmokers. After applying inclusion exclusion criteria their eligibility for recruitment, 25 control a healthy status good oral hygiene maintenance included. Unstimulated saliva was obtained evaluated using enzyme-linked immunosorbent assay, following parameters documented: [plaque index, bleeding on probing, pocket depth, attachment loss]. Results The mean levels all salivary citH3, ELA, CALPRO, MPO elevated groups than controls. Moreover, biomarker‘s significantly higher smoker In addition, correlations significant CALPRO CitH3 smokers ELA Conclusions results this showed that chosen revealed accuracy differentiating studied from smoking increases risk periodontitis, neutrophils exhibited more susceptibility form extracellular traps when compared nonsmokers.

Language: Английский

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A New Method for Volumetric Analysis of Soft‐Tissue Changes Using Three‐Dimensional Imaging in Patients With Periodontitis

Journal Of Clinical Periodontology, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

ABSTRACT Aims To quantify changes in soft‐tissue volume induced by non‐surgical periodontal therapy (NSPT) patients with periodontitis and correlate them clinical parameters smoking. A new digital approach is investigated because standard assessment methods are unable to accurately capture volumetric changes. Materials Methods Thirty‐nine subjects aged 27–70 years (median 48; 51% females; 49% smokers) were included. All underwent examination intraoral scanning at baseline 8 weeks after NSPT. Digital models superimposed, analysed correlated parameters. Results NSPT reduced both smokers non‐smokers ( p < 0.001). Non‐smokers had a higher median change than (267.4 vs. 210.5 mm 3 ), without statistically significant differences. Periodontal linearly In multiple linear regression, initial proportion of pockets ≥ 5 was the only predictor when effects plaque score, smoking status, age sex controlled for = 0.015). Conclusion resulted comparable reductions non‐smokers, which confirmed approach. Trial Registration: ClinicalTrials.gov : NCT05719519, 25.01.2023

Language: Английский

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The Influence of Genetic Polymorphisms on the Expression of Interleukin-1beta, Prostaglandin E2 and Tumor Necrosis Factor Alpha in Peri-Implant Crevicular Fluid: A Cross-Sectional Study

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(1), P. 651 - 651

Published: Jan. 4, 2024

The aim of this study was to evaluate the possible relationships between polymorphisms in interleukin-1 (IL-1) A, IL-1B, and IL-1RN genes concentrations inflammatory mediators IL-1β, tumor necrosis factor-alpha (TNF-α), prostaglandin E2 (PGE2) peri-implant crevicular fluid (PICF). A cross-sectional analytical conducted on 51 patients with dental implants. Samples from buccal mucosa were obtained, genetic analysis performed using real-time polymerase chain reaction (PCR) technique for IL-1A IL-1B PCR restriction fragment length polymorphism IL-1RN. For biochemical analysis, IL-1β TNF-α analyzed multiplexed fluorescent sphere immunoassays, PGE2 by enzyme-linked immunosorbent assay. In detected polymorphism, there an increase concentration three statistically significant differences mean values PGE2, regardless health status (p = 0.002 p 0.049, respectively). all positively significantly correlated (IL-1β vs. Rho 0.480, < 0.001; 0.382, 0.006; 0.528, 0.001). We can conclude that exerts influence PICF immune response, which may explain occurrence peri-implantitis.

Language: Английский

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Microbiological and Salivary Biomarkers Successfully Predict Site-Specific and Whole-Mouth Outcomes of Nonsurgical Periodontal Treatment

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4256 - 4256

Published: July 21, 2024

Background/Objectives: Nonsurgical periodontal treatment (NSPT) is the gold-standard technique for treating periodontitis. However, an individual's susceptibility or inadequate removal of subgingival biofilms could lead to unfavorable responses NSPT. This study aimed assess potential salivary and microbiological biomarkers in predicting site-specific whole-mouth outcomes Methods: A total 68 periodontitis patients exhibiting 1111 pockets 4 6 mm depth completed active phase treatment. Clinical parameters, saliva, biofilm samples were collected from each patient at baseline three months after quantitative PCR assay was used detect presence Fusobaterium nucleatum Porphyromonas gingivalis samples. Salivary including matrix metalloproteinase (MMP)-9, glutathione S-transferase (GST), Annexin-1 assayed both qualitatively (Western blot analysis) quantitively (ELISA). Results: NSPT yielded significant improvements all clinical a reduction bacterial load decreased levels MMP-9 together with increased concentrations GST Annexin-1. The binary logistic regression suggested that overall accuracy P. identification, probing pocket depth, interproximal sites 71.1% successful outcomes. biomarker model 79.4% following Conclusions: At baseline, shallow interdental locations lower abundance predictive favorable response site level. Decreased associated can predict

Language: Английский

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Salivary interleukin-17A and interleukin-18 levels in patients with celiac disease and periodontitis

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17374 - e17374

Published: May 13, 2024

An increased level of interleukin-17A and interleukin-18 in the serum intestinal mucosa celiac disease patients reflecting severity villous atrophy inflammation was documented. Thus, objective this study to evaluate concentrations salivary-17A, interleukin-1 beta, with who are on a gluten-free diet, both without periodontitis, compare these levels those healthy individuals.

Language: Английский

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Does the guideline-based physical activity level for cardiovascular health also benefit periodontal health?

Journal of Dental Sciences, Journal Year: 2023, Volume and Issue: 19(1), P. 46 - 50

Published: June 16, 2023

It is unclear about whether the guideline-based physical activity (PA) level for cardiovascular health also benefits periodontal health. Therefore, this study aimed to clarify association between PA levels and periodontitis in young adults. This was a cross-sectional which included 334 military participants, aged 18–44 years Taiwan. The assessed by total running time per week (wk) past 6 months from self-reported questionnaire, classified as moderate intensity <150, 150–299, ≥300 min/wk according American guideline Periodontitis defined based on 2017 World Workshop. Multiple logistic regression analysis used determine with adjustment age, sex, educational level, tobacco smoking, alcohol intake, body mass index, waist circumference, blood pressure teeth brushing frequency. As compared PA: 150–299 min/wk, <150 associated greater possibility of (odds ratio (OR): 2.45 (95% confidence interval (CI): 1.24–4.82), whereas not (OR: 0.98 CI: 0.13–1.09)) ≥150 found have superior However, there no additional benefit more exercise obtain better when suggested has been achieved.

Language: Английский

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Analysis of impact of consumption of proton pump inhibitor on osseointegration of dental implants to the alveolar bone -a systematic critical appraisal

Journal of the Pakistan Medical Association, Journal Year: 2023, Volume and Issue: 74(1), P. 108 - 113

Published: Dec. 24, 2023

Proton pump inhibitors are one of the most frequently prescribed medicines primarily for reducing production gastric acid. Every medicine has some adverse effects associated with it, including on bone tissues. Dental implant is preferred options teeth replacement. The current literature review was planned to evaluate association between intake proton and its impact around dental implant. Literature entailed search Google Scholar, Web Science PubMed databases using a range terms. Chronic been decrease in density bone, which eventually leads increased risk failure. However, since limited studies have carried out, further research required, especially clinical trials, relationship failure implants.

Language: Английский

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Factors associated with health-related quality of life on mental and oral health in patients with cancer and cancer survivors using the Korea National Health and Nutrition Examination Survey (2005–2018)

Asia-Pacific Journal of Oncology Nursing, Journal Year: 2024, Volume and Issue: 11(4), P. 100398 - 100398

Published: Feb. 3, 2024

ObjectiveTo investigate the association of mental and oral health with health-related quality life (HRQOL) in patients cancer survivors.MethodsThis cross-sectional study involved 1,643 1,628 individuals who survived (aged ≥ 19 years) using data from 2005–2018 Korean National Health Nutrition Examination Survey. The were analyzed SAS survey procedures (version 9.4), t-tests, χ2 test, multiple regression.ResultsRegarding differences factors by group, results revealed significant between depression, suicidal ideation, subjective health, chewing problems, speaking problems due to issues. HRQOL was lower than that survivors. influencing both survivors education status, economic activity, also associated depression cancer.ConclusionPatients had a two groups showed HRQOL. Therefore, customized programs policies should be developed implemented for each group improve their QOL.

Language: Английский

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Nicotine reduces cell viability and induces oxidative stress in human gingival fibroblasts

Universa Medicina, Journal Year: 2024, Volume and Issue: 43(1), P. 20 - 30

Published: March 4, 2024

BackgroundNicotine, as the main component of cigarettes, is known to interfere with proliferation human gingival fibroblasts (HGFs) and can trigger oxidative stress. This study aimed analyze impact nicotine on viability, expression antioxidant Nrf2, levels product stress malondialdehyde (MDA), migration capacity HGFs. MethodsAn experimental laboratory used isolated from healthy gingiva. The cells were grouped into non-treatment control group (NTC), solvent (SC), treatment groups, exposed at various concentrations for twenty-four hours. Cell viability was assesed using cell counting kit-8 (CCK-8), Nrf2 examined ELISA, MDA level measured an kit, assessed a scratch assay. Statistical analysis one-way Anova or Kruskal-Wallis test. A p-value <0.05 expressed statistically significant. ResultsThe substantially reduced in compared untreated group, accompanied by changes morphology. In contrast, increased significantly (p=0.010) 5 mM group. not distinct across groups (p=0.056). delayed 72 hours after scratching ConclusionNicotine decreased HGFs dose-dependent manner. Nicotine concentration did alter but migration.

Language: Английский

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