Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

Journal of Hepatology, Journal Year: 2017, Volume and Issue: 68(3), P. 526 - 549

Published: Oct. 12, 2017

Language: Английский

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Evolving therapeutic landscape of advanced hepatocellular carcinoma

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2022, Volume and Issue: 20(4), P. 203 - 222

Published: Nov. 11, 2022

Language: Английский

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YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma

Cancer Letters, Journal Year: 2018, Volume and Issue: 442, P. 252 - 261

Published: Nov. 10, 2018

N6-methyladenosin (m6A) is one of the most pervasive modification mRNA in eukaryotes and m6A methyltransferases demethylases play critical roles many types cancer. However role m6A-binding proteins cancer remains elusive. Here we report that down-regulation YTHDF2 was specifically induced by hypoxia hepatocellular carcinoma (HCC) cells, overexpression suppressed cell proliferation, tumor growth activation MEK ERK HCC cells. Mechanistically, directly bound site EGFR 3'-UTR to promote degradation This first showing may act as a suppressor repress proliferation via destabilizing HCC.

Language: Английский

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Rethink of EGFR in Cancer With Its Kinase Independent Function on Board

Frontiers in Oncology, Journal Year: 2019, Volume and Issue: 9

Published: Aug. 23, 2019

The epidermal growth factor receptor (EGFR) is one of most potent oncogenes that are commonly altered in cancers. As a tyrosine kinase, EGFR's kinase activity has been serving as the primary target for developing cancer therapeutics, namely EGFR inhibitors including small molecules targeting its ATP binding pocket and monoclonal antibodies ligand domains. have produced impressive therapeutic benefits to responsive types However, acquired innate resistances precluded current anti-EGFR agents from offering sustainable initially cancers EGFR-positive innately resistant. Recent years witnessed realization possesses kinase-independent (KID) pro-survival functions cells. This new knowledge offered different angle understanding opened avenue therapy. There already many excellent reviews on role with focus kinase-dependent mechanisms resistance targeted therapies. present opinion aims initiate fresh discussion about function cells by laying out some unanswered questions pertaining cells, rethinking unmet challenges view KID function, proposing novel approaches treatment.

Language: Английский

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Hepatocellular Carcinoma: Old and Emerging Therapeutic Targets

Cancers, Journal Year: 2024, Volume and Issue: 16(5), P. 901 - 901

Published: Feb. 23, 2024

Liver cancer, predominantly hepatocellular carcinoma (HCC), globally ranks sixth in incidence and third cancer-related deaths. HCC risk factors include non-viral hepatitis, alcohol abuse, environmental exposures, genetic factors. No specific alterations are unequivocally linked to tumorigenesis. Current standard therapies surgical options, systemic chemotherapy, kinase inhibitors, like sorafenib regorafenib. Immunotherapy, targeting immune checkpoints, represents a promising avenue. FDA-approved checkpoint such as atezolizumab pembrolizumab, show efficacy, combination enhance clinical responses. Despite this, the treatment of (HCC) remains challenge, complex tumor ecosystem immunosuppressive microenvironment associated with it hamper efficacy available therapeutic approaches. This review explores current advanced approaches treat HCC, considering both known new potential targets, especially derived from proteomic analysis, which is today considered most approach. Exploring novel strategies, this discusses antibody drug conjugates (ADCs), chimeric antigen receptor T-cell therapy (CAR-T), engineered antibodies. It then reports systematic analysis main ligand/receptor pairs molecular pathways reported be overexpressed cells, highlighting their limitations. Finally, TGFβ, one targets microenvironment.

Language: Английский

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Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis

Journal of Trace Elements in Medicine and Biology, Journal Year: 2019, Volume and Issue: 56, P. 60 - 68

Published: Aug. 1, 2019

Language: Английский

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Signaling pathways in hepatocellular carcinoma

Advances in cancer research, Journal Year: 2020, Volume and Issue: unknown, P. 63 - 101

Published: Nov. 24, 2020

Language: Английский

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<p>Hepatocellular Carcinoma Mechanisms Associated with Chronic HCV Infection and the Impact of Direct-Acting Antiviral Treatment</p>

Journal of Hepatocellular Carcinoma, Journal Year: 2020, Volume and Issue: Volume 7, P. 45 - 76

Published: April 1, 2020

Abstract: Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC). The mechanisms of HCC initiation, growth, metastasis appear to be highly complex due decade-long interactions between virus, immune system, overlapping bystander effects host metabolic disease. lack a readily accessible animal model system HCV significant obstacle understand viral carcinogenesis. Traditionally, primary prevention strategy has been eliminate by antiviral therapy. success elimination treatment determined SVR when no longer detectable in serum. Interferon-alpha (IFN-α) its analogs, pegylated IFN-α (PEG-IFN-α) alone with ribavirin (RBV), have many years low cure rate. cloning sequencing allowed development cell culture models, which accelerated drug discovery. It resulted selection effective direct-acting (DAA)-based combination therapy that now offers incredible curing more than 95% all patients, including those cirrhosis. However, several emerging recent publications claim patients who at time DAAs face occurrence recurrence after cure. This remains substantial challenge while addressing long-term benefit medicine. host-related drive absence are unknown. review describes multifaceted create tumorigenic environment during chronic infection. In addition potential oncogenic programming drives clearance DAAs, current status biomarker early prediction regression detection post discussed. Since does not provide full protection against reinfection or transmission other individuals, studies vaccine also reviewed. Keywords: hepatitis HCV, carcinoma, HCC, interferon, IFN, antiviral, DAA, endoplasmic reticulum stress, ER autophagy

Language: Английский

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Role of Rad51 and DNA repair in cancer: A molecular perspective

Pharmacology & Therapeutics, Journal Year: 2020, Volume and Issue: 208, P. 107492 - 107492

Published: Jan. 27, 2020

Language: Английский

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Lgr5 ⁺ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(39), P. 19530 - 19540

Published: Sept. 5, 2019

Significance Liver has a remarkable regenerative capacity following injuries. However, the cellular dynamics of how hepatocytes are replenished during homeostasis and upon liver injuries remains largely unclear. By using genetic lineage tracing strategies on rare Lgr5 + surrounding central veins lobule, this study shows that self-maintained normal various injuries, contributed to hepatocarcinogesis in two different hepatocellular carcinoma (HCC) models. Our findings provide an insight hepatocyte regeneration under uncover as potential origin HCC development.

Language: Английский

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