Proteins Regulating Microvesicle Biogenesis and Multidrug Resistance in Cancer

PROTEOMICS, Journal Year: 2018, Volume and Issue: 19(1-2)

Published: Dec. 6, 2018

Abstract Microvesicles (MV) are emerging as important mediators of intercellular communication. While MVs signaling vectors for many physiological processes, they also implicated in cancer pathology and progression. Cellular activation is perhaps the most widely reported initiator MV biogenesis, however, precise mechanism remains undefined. Uncovering proteins involved regulating biogenesis interest given their role dissemination deleterious traits. shed from drug‐resistant cells transfer multidrug resistance (MDR) to drug‐sensitive confer MDR phenotype a matter hours. attributed overexpression ABC transporters, primarily P‐glycoprotein MRP1. Their expression functionality dependent on number proteins. In particular, FERM domain have been supporting efflux transporters recipient during by vesicles. Herein, recent research MV‐mediated discussed. Attention drawn unanswered questions literature that may prove be benefit ongoing efforts improve clinical response chemotherapy circumventing MDR.

Language: Английский

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New landscapes and horizons in hepatocellular carcinoma therapy

Aging, Journal Year: 2020, Volume and Issue: 12(3), P. 3053 - 3094

Published: Feb. 4, 2020

Hepatocellular carcinoma (HCC), is the sixth most frequent form of cancer and leads to fourth highest number deaths each year.HCC results from a combination environmental factors aging as there are driver mutations at oncogenes which occur during aging.Most HCCs diagnosed advanced stage preventing curative therapies.Treatment in challenging pressing problem, novel welltolerated therapies urgently needed.We will discuss further advances beyond sorafenib that target additional signaling pathways immune checkpoint proteins.The scenario possible systemic for patients with HCC has changed dramatically recent years.Personalized genomics various other omics approaches may identify actionable biochemical targets, activated individual patients, enhance therapeutic outcomes.Further studies needed predictive biomarkers aberrantly capable guiding clinician choosing appropriate therapy patient.20.

Language: Английский

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Autoantibody signature in hepatocellular carcinoma using seromics

Journal of Hematology & Oncology, Journal Year: 2020, Volume and Issue: 13(1)

Published: July 2, 2020

Abstract Background Alpha-fetoprotein (AFP) is a widely used biomarker for hepatocellular carcinoma (HCC) early detection. However, low sensitivity and false negativity of AFP raise the requirement more effective diagnostic approaches HCC. Methods We employed three-phase strategy to identify serum autoantibody (AAb) signature HCC diagnosis using protein array-based approach. A total 1253 samples from HCC, liver cirrhosis, healthy controls were prospectively collected three cancer centers in China. The Human Proteome Microarray, comprising 21,154 unique proteins, was first applied AAb candidates discovery phase ( n = 100) further fabricate HCC-focused arrays. Then, an artificial neural network (ANN) model discover AAbs detection test 576) validation 577), respectively. Results Using array, we identified validated novel 7-AAb panel containing CIAPIN1, EGFR, MAS1, SLC44A3, ASAH1, UBL7, ZNF428 ANN this showed improvement (61.6–77.7%) compared (cutoff 400 ng/mL, 28.4–30.7%). Notably, it able detect AFP-negative with AUC values 0.841–0.948. For early-stage (BCLC 0/A) detection, outperformed ng/mL) approximately 10% increase AUC. Conclusions provides potentially clinical value non-invasive brings new clues on understanding immune response against hepatocarcinogenesis.

Language: Английский

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Dysregulation of Wnt/β‐catenin signaling by protein kinases in hepatocellular carcinoma and its therapeutic application

Cancer Science, Journal Year: 2021, Volume and Issue: 112(5), P. 1695 - 1706

Published: Feb. 21, 2021

Abstract Wnt/β‐catenin signaling is indispensable for many biological processes, including embryonic development, cell cycle, inflammation, and carcinogenesis. Aberrant activation of the can promote tumorigenicity enhance metastatic potential in hepatocellular carcinoma (HCC). Targeting this pathway a new opportunity precise medicine HCC. However, inhibiting alone unlikely to significantly improve HCC patient outcome due lack specific inhibitors complexity pathway. Combination with other therapies will be an important next step improving efficacy inhibitors. Protein kinases play key evolutionarily conserved role have become one most drug targets cancer. its regulatory kinase together promising management strategy. In review, we summarize that modulate briefly discuss their molecular mechanisms. Furthermore, list some small molecules target may inhibit signaling, offer perspectives preclinical clinical studies.

Language: Английский

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Advances in exosome analysis

Advances in clinical chemistry, Journal Year: 2022, Volume and Issue: unknown, P. 69 - 117

Published: Dec. 20, 2022

Language: Английский

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