Functional role of branched chain amino acids in poultry: a review DOI Creative Commons
Woo Kyun Kim, Amit Kumar Singh, Jinquan Wang

et al.

Poultry Science, Journal Year: 2022, Volume and Issue: 101(5), P. 101715 - 101715

Published: Jan. 12, 2022

This review provides insight into the effects of branched-chain amino acids (BCAA: leucine, isoleucine, and valine) on growth, production performance, immunity, intestinal health poultry. Besides providing nitrogen substrates carbon framework for energy homeostasis transamination, BCAA also function as signaling molecules in regulation glucose, lipid, protein synthesis via kinase B a mechanistic target rapamycin (AKT-mTOR) pathway that is important muscle accretion. The level leucine generally high cereals an imbalance ratio among 3 low diet would produce negative effect poultry growth performance. occurs due to structural similarity BCAA, which leads metabolic competition interference with enzymatic degradation pathway. Emerging evidence shows inclusion essential proper functioning innate adaptive immune system maintenance mucosal integrity. recommended levels are outlined by NRC (1994), but commercial broilers laying hen breed standards determine their own levels. In this review, it has been noted requirement influenced type, breed, age birds. Additionally, several studies focused diets strategy reduce excretion. Notably, there limited research supplemental form compared ingredient-bound affect dynamics utilization different disease-challenged conditions, especially those affecting digesta passage ratio. summary, encompasses role functional AA discusses physiological productivity observations interpretations can guide future adjust feeding programs absence subtherapeutic antibiotics

Language: Английский

Synthetic and Crystalline Amino Acids: Alternatives to Soybean Meal in Chicken-Meat Production DOI Creative Commons
Peter H. Selle, Juliano César de Paula Dorigam, A. Lemme

et al.

Animals, Journal Year: 2020, Volume and Issue: 10(4), P. 729 - 729

Published: April 22, 2020

: This review explores the premise that non-bound (synthetic and crystalline) amino acids are alternatives to soybean meal, dominant source of protein, in diets for broiler chickens. Non-bound essential non-essential can partially replace meal so requirements still met but dietary crude protein levels reduced. considers production acids, soybeans, discusses concept reduced-crude diets. There is a focus on specific including glycine, serine, threonine, branched-chain because they may be pivotal successful development Presently, moderate reductions approximately 30 g/kg feasible, more radical compromise performance. In theory, an ‘ideal’ acid profile would prevent this, this not necessarily case practice. The dependence chicken-meat industry will halved if order 50 attained without compromising growth performance event, synthetic crystalline, or non-bound, become viable production.

Language: Английский

Citations

79

Role of branched‐chain amino acids on growth, physiology and metabolism of different fish species: A review DOI Open Access
Ishtiyaq Ahmad, Imtiaz Ahmed, Shabihul Fatma Sayed

et al.

Aquaculture Nutrition, Journal Year: 2021, Volume and Issue: 27(5), P. 1270 - 1289

Published: April 14, 2021

Branched-chain amino acids (BCAAs), leucine, isoleucine and valine have an enormous functional significance because of their involvement in fish physiology. are not limited to act as substrates protein synthesis but also part the regulation. BCAAs regulate various key signalling pathways. Leucine has a pivotal role mTOR activation, while predominant energy glucose metabolism action. Research over years highlighted importance dietary levels on growth development fish. The available data suggest that require slightly higher amounts at initial stage than latter stages life. requirements different species indicated wide variations: 11.5 91.0 g leucine/kg protein, 15.4 42.3 isoleucine/kg 17.7 46.91 valine/kg protein. This review paper covers BCAA modulation action vital functions, synthesis, metabolic pathway, transportation immune response.

Language: Английский

Citations

60

Bioactive Compounds and Therapeutics from Fish: Revisiting Their Suitability in Functional Foods to Enhance Human Wellbeing DOI Creative Commons
Chinaza Godswill Awuchi, Charles Nnanna Chukwu, Adams Ovie Iyiola

et al.

BioMed Research International, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 18

Published: Aug. 5, 2022

Global public awareness about fish-based diet and its health/nutritional benefits is on the rise. Fish nutritional profile projects promising bioactive other compounds with innumerable health for human wellbeing. As various reported researches involving fish/marine-derived molecules reveal attributes, as position of nutrients nutraceuticals continue to strengthen, challenges still confront communities worldwide, from cardiovascular disease, diabetes, obesity hypertension. Thus, further understanding nutrient impact functional foods remains crucial given diverse prevailing compositional/nutraceutical merits. In this review, therefore, we provide important information regarding therapeutics obtained fish, specific context their suitability in enhance health. This contribution hereby constructed follows: (a) fish nutraceutical/therapeutic components, (b) constituents foods, (c) antioxidant/bioactive help alleviate conditions, (d) common ailments alleviated by nutrients, (e) role mental immune system. increased consumption should be encouraged, potential quality proteins, omega-3 fatty acids, inherent steadily harnessed.

Language: Английский

Citations

58

Role of Branched-Chain Amino Acid Metabolism in Type 2 Diabetes, Obesity, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease DOI Open Access
Paola Cuomo,

Rosanna Capparelli,

Antonio Iannelli

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(8), P. 4325 - 4325

Published: April 13, 2022

Branched-chain amino acids (BCAAs) include leucine, isoleucine, and valine. Mammalians cannot synthesize these de novo must acquire them through their diet. High levels of BCAAs are associated with insulin resistance; type 2 diabetes; obesity; non-metabolic diseases, including several forms cancer. BCAAs—in particular leucine—activate the rapamycin complex1 mTORC1, which regulates cell growth metabolism, glucose metabolism more essential physiological processes. Diets rich in metabolic diseases (listed above), while diets low generally reported to promote health. As for dysregulation caused by high BCAAs, recent studies propose that accumulation acyl-carnitine diacyl-CoA muscles alters lipid metabolism. However, this suggestion is not broadly accepted. On clinical grounds, pre- post-operative profiles candidate patients bariatric surgery being used select optimal procedure each individual patient.

Language: Английский

Citations

56

Functional role of branched chain amino acids in poultry: a review DOI Creative Commons
Woo Kyun Kim, Amit Kumar Singh, Jinquan Wang

et al.

Poultry Science, Journal Year: 2022, Volume and Issue: 101(5), P. 101715 - 101715

Published: Jan. 12, 2022

This review provides insight into the effects of branched-chain amino acids (BCAA: leucine, isoleucine, and valine) on growth, production performance, immunity, intestinal health poultry. Besides providing nitrogen substrates carbon framework for energy homeostasis transamination, BCAA also function as signaling molecules in regulation glucose, lipid, protein synthesis via kinase B a mechanistic target rapamycin (AKT-mTOR) pathway that is important muscle accretion. The level leucine generally high cereals an imbalance ratio among 3 low diet would produce negative effect poultry growth performance. occurs due to structural similarity BCAA, which leads metabolic competition interference with enzymatic degradation pathway. Emerging evidence shows inclusion essential proper functioning innate adaptive immune system maintenance mucosal integrity. recommended levels are outlined by NRC (1994), but commercial broilers laying hen breed standards determine their own levels. In this review, it has been noted requirement influenced type, breed, age birds. Additionally, several studies focused diets strategy reduce excretion. Notably, there limited research supplemental form compared ingredient-bound affect dynamics utilization different disease-challenged conditions, especially those affecting digesta passage ratio. summary, encompasses role functional AA discusses physiological productivity observations interpretations can guide future adjust feeding programs absence subtherapeutic antibiotics

Language: Английский

Citations

52