Alpha-Linolenic Acid and Cardiovascular Events: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 14319 - 14319

Published: Sept. 20, 2023

Cardiovascular diseases (CVDs) represent the leading cause of global mortality with 1.7 million deaths a year. One alternative systems to drug therapy minimize risk CVDs is represented by alpha-linolenic acid (ALA), an essential fatty omega-3 series, known for its cholesterol-lowering effect. The main purpose this review analyze effects ALA and investigate relevant omega-6/omega-3 ratio in order maintain functionally beneficial effects. Concerning lipid-lowering preventive effects, may favorably affect values LDL-C triglycerides both adult pediatric populations. Furthermore, has shown protective against hypertension, contributing balancing blood pressure through customary diet. According 2009 EFSA statement, dietary contribute reducing CVDs, thanks anti-hypertensive, anti-atherosclerotic cardioprotective

Language: Английский

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Protective role of arachidonic acid against diabetic myocardial ischemic injury: a translational study of pigs, rats, and humans

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Feb. 9, 2024

Abstract Aim Patients with diabetes mellitus have poor prognosis after myocardial ischemic injury. However, the mechanism is unclear and there are no related therapies. We aimed to identify regulators of diabetic Methods results Mass spectrometry-based, non-targeted metabolomic approach was used profile coronary sinus blood from non-diabetic Bama-mini pigs at 0.5-h post artery ligation. Six metabolites had a |log 2 (Fold Change)|> 1.3. Among them, most changed arachidonic acid (AA), levels which were 32 times lower in than pigs. The AA-derived products, PGI 6-keto-PGF 1α , also significantly reduced. AA treatment cultured cardiomyocytes protected against cell death by 30% 48 h high glucose oxygen deprivation, coincided increased mitophagic activity (as indicated LC3II/LC3I, decreased p62 parkin & PINK1), improved mitochondrial renewal (upregulation Drp1 FIS1), reduced ROS generation ATP production. These cardioprotective effects abolished PINK1(a crucial mitophagy protein) knockdown or autophagy inhibitor 3-Methyladenine. protective effect inhibited indomethacin Cay10441, prostacyclin receptor antagonist. Furthermore, Sprague Dawley rats subjected ligation for 40 min (10 mg/day per animal gavaged) infarct size, apoptosis index, inflammatory cytokines heart function. Scanning electron microscopy showed more intact mitochondria border zone infarcted myocardium treated rats. Lastly, patients infarction plasma cardiac ejection fraction, compared infarction. Plasma level inversely correlated fasting glucose. Conclusions protects damage promoting renewal, derived signaling. may represent new strategy treat

Language: Английский

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Influence of Omega n-6/n-3 Ratio on Cardiovascular Disease and Nutritional interventions

Human Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 37, P. 200275 - 200275

Published: June 11, 2024

According to the World Health Organization (WHO), cardiovascular disease (CVD) is number one cause of death globally. Centers for Disease Control and Prevention (CDC), in 2022, nearly 8 10 individuals who suffered from a stroke showed history hypertension, over 60% those with Diabetes have hypertension high triglycerides low-density lipoprotein (LDL, bad cholesterol). Both LDL double threat CVD incidence, probability all previous risk factors being higher adults are overweight obese. The n-6/n-3 polyunsaturated fatty acid (PUFA) ratio critical developing metabolic disorders that increase disease. elaboration mechanisms by which n-6 n-3 acids operate convert essential body will allow us clearly understand significance optimum two. research, human can maintain health an intake 5:1; however, current PUFA 20:1 Western diet. As heavy diet increases, we notice incline incidence rate syndromes through activating inflammatory pathways. Omega 6 omega 3 compete same enzyme binding site, depending on bound, resulting signals cascade pro-inflammatory or anti-inflammatory factors. This review discusses importance preventing, developing, progressing

Language: Английский

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Integrated metabolome and transcriptome analysis reveals key genes and pathways associated with egg yolk percentage in chicken

Poultry Science, Journal Year: 2025, Volume and Issue: 104(3), P. 104815 - 104815

Published: Jan. 17, 2025

Language: Английский

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Recent advances on dioxin and furan (dibenzofuran) based pollutants from analytical, environmental, and health perspectives

Chemosphere, Journal Year: 2025, Volume and Issue: 372, P. 144120 - 144120

Published: Jan. 21, 2025

Language: Английский

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