Mitochondrial dynamics in health and disease: mechanisms and potential targets

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Sept. 6, 2023

Abstract Mitochondria are organelles that able to adjust and respond different stressors metabolic needs within a cell, showcasing their plasticity dynamic nature. These abilities allow them effectively coordinate various cellular functions. Mitochondrial dynamics refers the changing process of fission, fusion, mitophagy transport, which is crucial for optimal function in signal transduction metabolism. An imbalance mitochondrial can disrupt function, leading abnormal fate, range diseases, including neurodegenerative disorders, cardiovascular diseases cancers. Herein, we review mechanism dynamics, its impacts on function. We also delve into changes occur during health disease, offer novel perspectives how target modulation dynamics.

Language: Английский

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New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury

Angiogenesis, Journal Year: 2020, Volume and Issue: 23(3), P. 299 - 314

Published: April 3, 2020

Language: Английский

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A cell atlas of the adultDrosophilamidgut

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(3), P. 1514 - 1523

Published: Jan. 8, 2020

Studies of the adult Drosophila midgut have led to many insights in our understanding cell-type diversity, stem cell regeneration, tissue homeostasis, and fate decision. Advances single-cell RNA sequencing provide opportunities identify new types molecular features. We used characterize transcriptome epithelial cells identified 22 distinct clusters representing intestinal cells, enteroblasts, enteroendocrine (EEs), enterocytes. This unbiased approach recovered most known cells/enteroblast EE markers, highlighting high quality dataset, on biology, type-specific organelle features, roles transcription factors progenitors regional variation along gut, 5 additional gut hormones, hormonal expression paracrine function EEs. To facilitate mining this rich we a web-based resource for visualization gene single cells. Altogether, study provides comprehensive addressing functions genes epithelium.

Language: Английский

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Energy Metabolism Regulates Stem Cell Pluripotency

Frontiers in Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 8

Published: Feb. 28, 2020

Pluripotent stem cells (PSCs) are characterized by their unique capacity for both unlimited self-renewal and potential to differentiate all cell lineages contained within the three primary germ layers. While once considered a distinct cellular state, it is becoming clear that pluripotency in fact continuum of states, capable differentiation, yet with metabolic, mitochondrial epigenetic features dependent on gestational stage. In this review we focus two most clearly defined states: "naïve" "primed" pluripotent (PSCs). Like other rapidly dividing cells, PSCs have high demand anabolic precursors necessary replicate genome, cytoplasm organelles, while concurrently consuming energy form ATP. This requirement catabolic processes sufficient supply highly adapted cycle context reduced oxygen availability, distinguishes from differentiated progeny, tumor cells. During early embryogenesis adapt substrate preference match energetic requirements developmental process. reflected different morphologies, membrane potentials electron transport chain compositions, utilization glycolysis. Additionally, metabolites produced can directly influence transcriptional programs, which turn affect characteristics. Thus, our understanding role metabolism PSC fate has expanded anabolism catabolism include governance landscape. Understanding roles factors influencing metabolic pathways naïve primed states provide platform drivers during development. highlights major acquisition maintenance pluripotency.

Language: Английский

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Mitochondrial dynamics and their potential as a therapeutic target

Mitochondrion, Journal Year: 2019, Volume and Issue: 49, P. 269 - 283

Published: June 19, 2019

Language: Английский

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Hematopoietic Stem Cell Metabolism during Development and Aging

Developmental Cell, Journal Year: 2020, Volume and Issue: 54(2), P. 239 - 255

Published: July 1, 2020

Language: Английский

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The Mitochondrion as an Emerging Therapeutic Target in Cancer

Trends in Molecular Medicine, Journal Year: 2019, Volume and Issue: 26(1), P. 119 - 134

Published: July 18, 2019

Language: Английский

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Regulation of Mammalian Mitochondrial Dynamics: Opportunities and Challenges

Frontiers in Endocrinology, Journal Year: 2020, Volume and Issue: 11

Published: June 11, 2020

Mitochondria are highly dynamic organelles and important for a variety of cellular functions. They constantly undergo fission fusion events, referred to as mitochondrial dynamics, which affects the shape, size, number mitochondria in cell, well subcellular transport, quality control (mitophagy), programmed cell death (apoptosis). Dysfunctional dynamics is associated with various human diseases. Mitochondrial mediated by set mitochondria-shaping proteins both yeast mammals. In this review, we describe recent insights into potential molecular mechanisms underlying fission, particularly highlighting coordinating roles different processes, endoplasmic reticulum (ER), actin cytoskeleton membrane phospholipids regulation dynamics. We focus on emerging mammalian Fis1, Mff, MIEFs (MIEF1 MIEF2) regulating recruitment cytosolic Drp1 surface how these proteins, especially mediate crosstalk between machineries. summary, review provides novel involvement apoptosis autophagy.

Language: Английский

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PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders

Pharmacology & Therapeutics, Journal Year: 2020, Volume and Issue: 219, P. 107705 - 107705

Published: Oct. 9, 2020

Language: Английский

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The Drp1-Mediated Mitochondrial Fission Protein Interactome as an Emerging Core Player in Mitochondrial Dynamics and Cardiovascular Disease Therapy

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5785 - 5785

Published: March 17, 2023

Mitochondria, the membrane-bound cell organelles that supply most of energy needed for function, are highly regulated, dynamic bearing ability to alter both form and functionality rapidly maintain normal physiological events challenge stress cell. This amazingly vibrant movement distribution mitochondria within cells is controlled by coordinated interplay between mitochondrial processes fission fusion events, as well quality-control processes, mainly autophagy (also known mitophagy). Fusion connects unites neighboring depolarized derive a healthy distinct mitochondrion. In contrast, segregates damaged from intact counterparts followed selective clearance via specific autophagy, i.e., mitophagy. Hence, encompass all fusion, fission, mitophagy, biogenesis sustaining homeostasis. Accumulated evidence strongly suggests impairment has already emerged core player in pathogenesis, progression, development various human diseases, including cardiovascular ailments, leading causes death globally, which take an estimated 17.9 million lives each year. The crucial factor governing process recruitment dynamin-related protein 1 (Drp1), GTPase regulates cytosol outer membrane guanosine triphosphate (GTP)-dependent manner, where it oligomerized self-assembles into spiral structures. this review, we first aim describe structural elements, functionality, regulatory mechanisms key protein, Drp1, other adaptor proteins, (Fis1), (Mff), dynamics 49 (Mid49), 51 (Mid51). area review focuses on recent advances understanding role Drp1-mediated interactome unravel missing links events. Lastly, discuss promising mitochondria-targeted therapeutic approaches involve current interactions their critical roles pathogeneses diseases (CVDs).

Language: Английский

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