Nanoformulations as a strategy to overcome the delivery limitations of cannabinoids

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(4), P. 1526 - 1538

Published: Feb. 7, 2023

Abstract Medical cannabis has received significant interest in recent years due to its promising benefits the management of pain, anxiety, depression and neurological movement disorders. Specifically, major phytocannabinoids derived from plant such as (−) trans‐Δ 9 ‐tetrahydrocannabinol (THC) cannabidiol (CBD), have been shown be responsible for pharmacological therapeutic properties. Recently, these also attracted special attention cancer treatment their well‐known palliative chemotherapy‐induced nausea, vomiting, pain loss appetite along with anticancer activities. Despite enormous benefits, low aqueous solubility, high instability (susceptibility extensive first pass metabolism) poor systemic bioavailability restrict utilization at clinical perspective. Therefore, drug delivery strategies based on nanotechnology are emerging improve pharmacokinetic profile cannabinoids well enhance targeted delivery. Here, we critically review nano‐formulation systems engineered overcoming limitations native including polymeric lipid‐based nanoparticles (lipid nano capsules (LNCs), nanostructured lipid carriers (NLCs), nanoemulsions (NE) self‐emulsifying (SEDDS)), ethosomes cyclodextrins applications.

Language: Английский

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Cannabis Use in Patients With Cancer: A Clinical Review

JCO Oncology Practice, Journal Year: 2022, Volume and Issue: 18(11), P. 743 - 749

Published: June 24, 2022

Cannabis use and interest continues to increase among patients with cancer caregivers. High-quality research remains scant in many areas, causing hesitancy or discomfort most clinical providers. Although we have limitations on hard outcomes, can provide some guidance more proactively engage conversations family about cannabis. Several studies support the efficacy of cannabis for various treatment-related symptoms, such as chemotherapy-induced nausea pain. formulations dosing guidelines clinicians do not formally exist at present, attention tetrahydrocannabinol concentration understanding risks inhalation reduce risk. Conflicting information exists interaction between immunotherapy well estrogen receptor interactions. Motivational interviewing help productive, less stigmatized conversations.

Language: Английский

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Cannabinoids in the Modulation of Oxidative Signaling

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2513 - 2513

Published: Jan. 28, 2023

Cannabis sativa-derived compounds, such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), components of the endocannabinoids system, N-arachidonoylethanolamide (anandamide, AEA) 2-arachidonoylglycerol (2-AG), are extensively studied to investigate their numerous biological effects, including powerful antioxidant effects. Indeed, a series recent studies have indicated that many disorders characterized by alterations in intracellular which lead macromolecule damage. These pathological conditions an unbalanced, most often increased, reactive oxygen species (ROS) production. For this study, it was interest recapitulate properties these natural for part CBD THC, on production ROS modulation redox state, with emphasis use various reduction can be clinically useful, neurodegenerative disorders, inflammatory conditions, autoimmunity, cancers. The further development ROS-based fundamental research focused cannabis compounds could beneficial future clinical applications.

Language: Английский

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Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches

Toxicological Sciences, Journal Year: 2019, Volume and Issue: 173(1), P. 32 - 40

Published: Oct. 4, 2019

Bisphenol F (BPF) is one of several A (BPA) substituents that increasingly used in manufacturing industry leading to detectable human exposure. Whereas a large number studies have been devoted decipher BPA effects, much less known about its substituents. To support decision making on BPF's safety, we developed new computational approach rapidly explore the available data toxicological combining text mining and integrative systems biology, aiming at connecting BPF adverse outcome pathways (AOPs). We first extracted from different databases BPF-protein associations were expanded protein complexes using protein-protein interaction datasets. Over-representation analysis allowed identify most relevant biological putatively targeted by BPF. Then, automatic screening scientific abstracts literature tool, AOP-helpFinder, combined with integration various sources (AOP-wiki, CompTox, etc.) manual curation us link AOP events. Finally, all information gathered through those analyses built comprehensive complex framework linking an network including, as outcomes, types cancers such breast thyroid malignancies. These results which integrate can regulatory assessment substituent, BPF, trigger epidemiological experimental studies.

Language: Английский

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Understanding Patterns of Brain Metastasis in Triple-Negative Breast Cancer and Exploring Potential Therapeutic Targets

OncoTargets and Therapy, Journal Year: 2021, Volume and Issue: Volume 14, P. 589 - 607

Published: Jan. 1, 2021

Triple-negative breast cancer (TNBC) is a highly malignant subtype of cancer. High invasiveness and heterogeneity, as well lack drug targets, are the main factors leading to poor prognosis. Brain metastasis (BM) serious event threatening life patients, especially those with TNBC. Compared that for hormone receptor-positive HER2-positive cancers, TNBC-derived BM (TNBCBM) occurs earlier more frequently, has worse There no standard treatment date, one urgently required. In this review, we discuss current knowledge regarding developmental patterns TNBCBM, focusing on key events in formation. Specifically, consider (i) nature function TNBC cells; (ii) how cells cross blood-brain barrier form fenestrated, permeable blood-tumor barrier; (iii) biological characteristics TNBCBM; (iv) infiltration colonization central nervous system (CNS) by cells, including establishment premetastatic niches, immunosurveillance escape, metabolic adaptations. We also putative therapeutic targets precision therapy greatest potential treat summarize relevant completed ongoing clinical trials. These findings may provide new insights into prevention patients.

Language: Английский

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Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells

Molecules, Journal Year: 2020, Volume and Issue: 25(20), P. 4682 - 4682

Published: Oct. 14, 2020

This study evaluated the synergistic anti-cancer potential of cannabinoid combinations across MDA-MB-231 and MCF-7 human breast cancer cell lines. Cannabinoids were combined their interactions using median effect analysis. The most promising combination (C6) consisted tetrahydrocannabinol, cannabigerol (CBG), cannabinol (CBN), cannabidiol (CBD), displayed favorable dose reduction indices limited cytotoxicity against non-cancerous line, MCF-10A. C6 exerted its effects in line by inducing cycle arrest G2 phase, followed induction apoptosis. Morphological observations indicated cytoplasmic vacuolation, with further investigation suggesting that vacuole membrane was derived from endoplasmic reticulum. In addition, lipid accumulation, increased lysosome size, significant increases reticulum chaperone protein glucose-regulated 78 (GRP78) expression also observed. selectivity ability cannabinoids to halt proliferation via pathways resembling apoptosis, autophagy, paraptosis shows promise for use standardized treatment.

Language: Английский

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Cannabinoids and Hormone Receptor-Positive Breast Cancer Treatment

Cancers, Journal Year: 2020, Volume and Issue: 12(3), P. 525 - 525

Published: Feb. 25, 2020

Breast cancer (BC) is the most common in women worldwide. Approximately 70–80% of BCs express estrogen receptors (ER), which predict response to endocrine therapy (ET), and are therefore hormone receptor-positive (HR+). Endogenous cannabinoids together with cannabinoid receptor 1 2 (CB1, CB2) constitute basis endocannabinoid system. Interactions hypothalamic–pituitary–gonadal axis hormones well documented, two studies found a positive correlation between peak plasma endogenous anandamide 17β-estradiol, luteinizing follicle-stimulating levels at ovulation healthy premenopausal women. Do have an effect on HR+ BC? In this paper we review known possible interactions specific BC treatments. preclinical studies, CB1 CB2 agonists (i.e., anandamide, THC) been shown inhibit proliferation ER cell lines. There less evidence for antitumor action animal models there no clinical trials exploring effects treatment outcomes. Two that tamoxifen several other selective modulators (SERM) can act as inverse CB2, interaction consequences. addition, could interact commonly used targeted therapies BC.

Language: Английский

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Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis

Biomolecules, Journal Year: 2020, Volume and Issue: 10(3), P. 402 - 402

Published: March 5, 2020

Apoptosis is the physiological mechanism of cell death and can be modulated by endogenous exogenous factors, including stress metabolic alterations. Reactive oxygen species (ROS), as well ROS-dependent lipid peroxidation products (including isoprostanes reactive aldehydes 4-hydroxynonenal) are proapoptotic factors. These mediators activate apoptosis via mitochondrial-, receptor-, or ER stress-dependent pathways. Phospholipid metabolism also an essential regulator apoptosis, producing prostaglandins PGD PGJ series, antiapoptotic PGE but 12-HETE 20-HETE. The effect endocannabinoids phytocannabinoids on depends type-specific differences. Cells where cannabinoid receptor type 1 (CB1) dominant receptor, cells with high cyclooxygenase (COX) activity, undergo after administration cannabinoids. In contrast, in CB2 receptors dominate, low COX cannabinoids act a cytoprotective manner. Therefore, differences pro- effects lipids their (oxidative) might reveal new options for differential bioanalysis between normal, functional, degenerating malignant cells, better integrative biomedical treatments major stress-associated diseases.

Language: Английский

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Comparative assessment of antimicrobial, antiradical and cytotoxic activities of cannabidiol and its propyl analogue cannabidivarin

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: Nov. 18, 2021

Abstract Cannabidiol and cannabidivarin are phytocannabinoids produced by Cannabis indica sativa . has been studied more extensively than its propyl analogue cannabidivarin. Therefore, we performed a battery of in vitro biological assays to compare the cytotoxic, antiradical antibacterial activities both cannabinoids. Potential mitochondrial metabolism alterations, DNA synthesis inhibition, plasma membrane damage were MTT assay, BrdU-ELISA LDH assay cancer normal human cells exposed ABTS DPPH observe effects cannabinoids on free radicals. Microbial susceptibility tests study activity two bacterial species implicated infections, Escherichia coli Staphylococcus aureus The results showed that induced medium levels cytotoxicity at concentrations ranging from 15.80 48.63 31.89 151.70 µM, respectively, after 72 h exposure. Cannabinoids did not exhibit strong antioxidant capacity scavenging or No evident differences observed between antimicrobial activity, except with respect S. , which greater cannabidiol

Language: Английский

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Advances in mitophagy and mitochondrial apoptosis pathway-related drugs in glioblastoma treatment

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 30, 2023

Glioblastoma (GBM) is the most common malignant tumor of central nervous system (CNS). It a leading cause death among patients with intracranial tumors. GBM exhibits intra- and inter-tumor heterogeneity, to drug resistance eventual recurrence. Conventional treatments for include maximum surgical resection glioma tissue, temozolomide administration, radiotherapy, but these methods do not effectively halt cancer progression. Therefore, development novel treatment identification new therapeutic targets are urgently required. In recent years, studies have shown that drugs related mitophagy mitochondrial apoptosis pathways can promote glioblastoma cells by inducing damage, impairing adenosine triphosphate (ATP) synthesis, depleting large amounts ATP. Some also modern nano-drug delivery technology targeting mitochondria achieve better release deeper tissue penetration, suggesting could be target intervention therapy. The combination autophagy nanotechnology promising approach treating GBM.This article reviews current status therapy GBM, pathways, potential as treatment, latest developments pertaining directions future research.

Language: Английский

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