Nicotinamide reduces inflammation and oxidative stress via the cholinergic system in fructose-induced metabolic syndrome in rats

Life Sciences, Journal Year: 2020, Volume and Issue: 250, P. 117585 - 117585

Published: March 31, 2020

Language: Английский

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COVID-19 and gastrointestinal system: A brief review

Biomedical Journal, Journal Year: 2021, Volume and Issue: 44(3), P. 245 - 251

Published: Jan. 18, 2021

COVID-19 is a recent pandemic that still major health problem of modern times and already more than 17.5 lakhs people succumbed to this deadly disease. This disease caused by novel coronavirus which named SARS-COV-2 the International Committee on Taxonomy Viruses. virus originated from Wuhan city in Hubei province China December 2019 within short period spread across many countries globe. There are lot basic as well clinical research going study mode transmission mechanism action infection its therapeutics. not only known infect lungs, but it also infects other organs human body including gastrointestinal (GI) tract, liver, pancreas via angiotensin-converting enzyme (ACE) 2, an important component renin-angiotensin system. In review, we mainly discussing transmission, physiological counterbalancing roles ACE2 ACE tissue patterns expression, overall effect COVID19 System. Therefore, review sheds light possible GI system pathological symptoms raising potential possibility tract acting secondary site for SARS-CoV-2 tropism infection. Finally, future studies understand fecal-oral correlation viral load severity proposed gain knowledge aid early diagnosis prognosis.

Language: Английский

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Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health

Frontiers in Endocrinology, Journal Year: 2021, Volume and Issue: 12

Published: April 19, 2021

The metabolic syndrome (MetS) is correlated with disorders of the reproductive system, such as polycystic ovary (PCOS). While consumption a diet rich in carbohydrates linked to development MetS, it still unclear if this leads ovarian dysfunction and PCOS.We investigated influence high-sucrose (HSD) on milieu Wistar rats studied correlation between high sugary drinks prevalence PCOS women.Wistar were given standard laboratory (CTR, 10% sucrose, n = 8) or HSD (HSD, 25% from postnatal day 21 120. Animals evaluated weekly calculate food intake, feed efficiency weight gain. Both onset puberty estrous cycle monitored. Metabolic serum biochemistry, organ morphometry histology performed upon euthanasia. In parallel, fixed-effects multiple linear regression analysis was using data Brazilian states (459 state-year observations) test sugar-sweetened beverages (surrogate for intake) dysfunction).HSD animals showed increased adipose tissue accumulation, hyperglycaemia insulin resistance when compared CTR. Interestingly also entered earlier than Moreover, ovaries had an number atretic antral follicles cystic follicles, which hypertrophy periovarian adipocytes. Finally, there positive intake women age.HSD ingestion could be women, suggesting these alterations lead public health issues. Therefore, we reinforce deleterious impact system suggest that reduction added sugars beneficial health.

Language: Английский

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The Effect of Exercise Intensity on Anthropometric Parameters and Renal Damage in High Fructose- Induced Mice

Retos, Journal Year: 2023, Volume and Issue: 51, P. 1194 - 1209

Published: Dec. 1, 2023

Excessive fructose intake disrupts carbohydrate and lipid metabolism in the kidney, resulting kidney injury. Exercise has proven to improve renal fatty acid metabolism, but effect of various exercise intensities preventing disorders is still unknown. The purpose this study analyze on anthropometric parameters damage high fructose-induced mice. subjects were thirty-six male mice (20–30 g), aged 8 weeks obtained randomly assigned into 4 groups: HFr-Sed (sedentary), HFr-Ex1 (low-intensity exercise), HFr-Ex2 (moderate-intensity HFr-Ex3 (high-intensity exercise). They fed standard chow solution (30%), per-oral, ad libitum for weeks. exercised groups underwent swimming, with 80% maximum duration/session, 3x/week, result showed that there significant differences body weight (p < 0.001), length = Lee index 0.020), Body Mass Index (BMI) 0.004), serum creatinine (SCr) level 0.001). However, glomerulosclerosis interstitial fibrosis degree not significantly different all groups. It can be concluded affect composition SCr level, especially moderate-intensity exercise, do impact improvement histological Keyword: Exercise, healthy lifestyle, obesity, histology.

Language: Английский

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The relationship between major food sources of fructose and cardiovascular disease, cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of cohort studies

Critical Reviews in Food Science and Nutrition, Journal Year: 2021, Volume and Issue: 63(20), P. 4274 - 4287

Published: Nov. 30, 2021

We aimed to summarize the associations between food sources of fructose and cardiovascular diseases (CVD), cancer, all-cause mortality risk using a systematic review meta-analysis. searched PubMed, Scopus, Web Science up November 2020. included cohort studies that investigated relationship (all-cause, CVD, specific total site-specific cancers) intake ≥1 source (fruit, fruit juice, breakfast cereals, sugar-sweetened beverages (SSBs), sweets, yogurt) in general adult population. Summary hazard ratios 95% CIs were estimated random-effects model for linear nonlinear relationships. Findings indicated each 100 g/d increase was associated with 8-13% lower CVDs, stroke, gastrointestinal, lung cancer mortality. For mortality, there beneficial 200 fruit, then plateaued. ischemic heart disease 300 followed by slight increase. Ingestion cereals sweets also yogurt, non-linear marginal decrease found. yogurt 14% CVD Every 60 sweet linked 5% Contrariwise, every 250 SSBs 7–10% higher In conclusion, found and/or risk. Fruit had an inverse link Conversely, harmful mortality.Registry number: CRD42019144956

Language: Английский

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