Trends in Pharmacological Sciences, Journal Year: 2020, Volume and Issue: 41(11), P. 851 - 867
Published: Oct. 1, 2020
Language: Английский
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(10), P. 8123 - 8143
Published: March 12, 2024
Language: Английский
Citations
9
Brain Science Advances, Journal Year: 2019, Volume and Issue: 5(4), P. 288 - 298
Published: Dec. 1, 2019
Increases in depressive behaviors have been reported patients experiencing chronic pain. In these patients, the symptoms of pain and depression commonly coexist, impairing their lives challenging effective treatment. The hippocampus may play a role both depression. A reduction volume is related to reduced neurogenesis neuroplasticity cases Moreover, an increase proinflammatory factors neurotrophic modulate hippocampal This review discusses mechanisms underlying depressive-like behavior accompanying pain, emphasizing structural functional changes hippocampus. We also discuss hypothesis that pro-inflammatory expressed serve as therapeutic target for comorbid
Language: Английский
Citations
61
Neuromodulation Technology at the Neural Interface, Journal Year: 2020, Volume and Issue: 24(1), P. 68 - 75
Published: June 27, 2020
Language: Английский
Citations
53
Open Access Rheumatology Research and Reviews, Journal Year: 2021, Volume and Issue: Volume 13, P. 31 - 43
Published: March 1, 2021
Abstract: Pain is a major and common symptom reported as top priority in patients with rheumatoid arthritis (RA). Intuitively, RA-related pain often considered to be natural consequence of peripheral inflammation, so treatment RA expected manage concurrently part inflammation control. However, can poorly correlated objective measures for example, who are otherwise remission. Joint damage appears account only fraction this residual pain. Emerging evidence suggests that alteration central processing contributes pain; parallel to, but somewhat independent of, joint inflammation. Interleukin (IL)-6 proinflammatory cytokine the pathogenesis RA. It exerts systemic effects via signaling through soluble forms IL-6 receptor ("trans-signaling"). Evidence from preclinical studies demonstrates intra-articular produce long-lasting sensitization mechanical stimulation an important role sensitization. This may partly explained by its ability activate neurons trans-signaling, affecting nociceptive plasticity nerve fiber regrowth. Local activity at neuron endings culminate altered nervous system because persistent sensitized neurons. Peripheral promote development chronic pain, which have significant impact on patients' health quality life. A proportion more appropriately managed entity separate Both systems should recognized potential targeted The substantial burden key focus management assessed addressed early separately inflammatory component. Keywords: animal model, non-inflammatory,
Language: Английский
Citations
50
Neuropharmacology, Journal Year: 2021, Volume and Issue: 197, P. 108712 - 108712
Published: July 16, 2021
Language: Английский
Citations
45
Frontiers in Pain Research, Journal Year: 2022, Volume and Issue: 3
Published: July 4, 2022
Chronic pain is a long-standing unpleasant sensory and emotional feeling that has tremendous impact on the physiological functions of body, manifesting itself as dysfunction nervous system, which can occur with peripheral central sensitization. Many recent studies have shown variety common immune cells in system are involved chronic by acting or especially autoimmune diseases. This article reviews mechanisms regulation neutrophils, macrophages, mast cells, B T glial cells. In addition, we discuss more detail influence each cell initiation, maintenance, resolution pain. Neutrophils, intrinsic induce transition from acute to its maintenance; adaptive mainly initiation pain, also contribute it; role be extended beginning end aims promote understanding neuroimmune provide new therapeutic ideas strategies for control at cellular level.
Language: Английский
Citations
34
International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(5), P. 2964 - 2964
Published: March 3, 2022
The global burden of chronic low back pain (CLBP) is a major concern in public health. Several CLBP epidemiological studies have been conducted high-income-countries (HICs) with little known low-and-middle-income-countries (LMICs) due to other competing priorities communicable diseases. extrapolation results from HICs for use LMICs difficult differences social norms, healthcare systems, and legislations, yet there urgent need address this growing burden. It against backdrop that we review map the current evidence on distribution Sub-Saharan Africa (SSA).A comprehensive literature search was following databases: PubMed, Google Scholar, Science Direct databases, World Health Organizations library EMBASE, EBSCOhost by searching databases within platform; academic complete, CINAHL full text, health sources: nursing/academic MEDLINE. title, abstract text screening phases were performed two independent reviewers third reviewer employed adjudicate discrepancies. reference list all included articles also searched eligible articles. This scoping reported accordance PRISMA extension reviews (PRISMA-ScR): checklist explanation, as well guided Arksey O'Malley's framework. A thematic content analysis used give narrative account review.The electronic strategy retrieved 21,189 Title/abstract only identified 11 articles, which review. prevalence among general population ranged 18.1% 28.2% 22.2% 59.1% LBP patients. occupation based 30.1% 55.5%. Identified risk factors are multifactorial biomechanical, psychological, socioeconomic lifestyle factors, psychosocial playing significant role. Hypertension, diabetes mellitus, peptic ulcer disease most common comorbidities identified. disability significantly associated factors. management primary care follows traditional biomedical paradigm primarily involves medication inconsistent guidelines.There limited data SSA, however, study concluded SSA comparable reports HICs. Considering projected increase extensive research effort needed close knowledge gap.
Language: Английский
Citations
31
Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13
Published: May 10, 2022
Chronic pain is one of the most prevalent health problems. The establishment chronic complex. Current medication for mainly dependent on anticonvulsants, tricyclic antidepressants and opioidergic drugs. However, they have limited therapeutic efficacy, some even with severe side effects. We turned our interest into alkaloids separated from traditional Chinese medicine (TCM), that usually act multiple drug targets. In this article, we introduced best-studied analgesic derived TCM, including tetrahydropalmatine, aloperine, oxysophocarpine, matrine, sinomenine, ligustrazine, evodiamine, brucine, tetrandrine, Stopholidine, lappaconitine, focusing their mechanisms potential clinical applications. To better describe mechanism these alkaloids, adopted concept drug-cloud (dCloud) theory. dCloud illustrated full spectrum multitarget analgesics two dimensions, which are “direct efficacy”, inhibition ion channels, activating γ-Aminobutyric Acid/opioid receptors, to suppress signal directly; “background reducing neuronal inflammation/oxidative stress, glial cell activation, restoring balance between excitatory inhibitory neurotransmission, cure root causes pain. Empirical evidence showed combination beneficial 30–50% patients. promote discovery effective combinations, an ancient regimen combines herbal drugs “Jun”, “Chen”, “Zuo”, “Shi” properties. dCloud, “Jun” acts directly major symptom disease; “Chen” generates background effects; “Zuo” has salutary supportive functions; facilitates delivery targeted tissue. Subsequently, using concept, interpreted effect established compositions containing TCM may contribute alternative model.
Language: Английский
Citations
29
BMC Medicine, Journal Year: 2023, Volume and Issue: 21(1)
Published: May 4, 2023
Chronic musculoskeletal pain has been linked to dementia; however, chronic typically occurs in multiple sites; therefore, this study was investigate whether greater number of sites is associated with a higher risk dementia and its subtypes.
Language: Английский
Citations
22
Anaesthesia, Journal Year: 2023, Volume and Issue: 79(2), P. 128 - 138
Published: Dec. 6, 2023
Summary The numerical rating scale and visual analogue are used to quantify pain intensity. However, it has not yet been explored whether these scores interchangeable in adults with chronic pain. Data from the prospective multicentre cross‐sectional INTERVAL study were evaluate one‐dimensionality agreement between Pain intensity using provided by 366 patients for current, average, minimal maximal To scales completed accordance each other, proportion of who satisfied following condition was calculated: ≤ A factor analysis confirmed measures. significant difference found minimum maximum Intra‐class correlation coefficient estimates ranged 0.739 0.858 all measures failed show sufficient acceptable at 95% level. strength severity categories classified as ‘moderate’ average ‘substantial’ current scored 97.5% 89.5% scale. This an when rated pain, despite showing both measure same information.
Language: Английский
Citations
17