Biomolecules,
Journal Year:
2019,
Volume and Issue:
9(11), P. 691 - 691
Published: Nov. 3, 2019
Renal
injury
induced
by
the
chemotherapeutic
agent
methotrexate
(MTX)
is
a
serious
adverse
effect
that
has
limited
its
use
in
treatment
of
various
clinical
conditions.
The
antioxidant
activity
Ginkgo
biloba
extract
(GB)
was
reported
to
mitigate
renal
MTX.
Our
research
conducted
examine
nephroprotective
role
GB
versus
MTX-induced
for
first
time
through
impact
on
regulation
phosphatidylinositol
3-kinase/protein
kinase
B/
mammalian
target
rapamycin
(PI3K/Akt/mTOR)
signaling
together
with
level
TGF-β
mRNA
and
long
non-coding
RNA-metastasis-associated
lung
adenocarcinoma
transcript-1
(MALAT1)
expression.
A
group
adult
rats
intraperitoneally
(ip)
injected
MTX
20
mg/kg
as
single
dose
induce
kidney
(MTX
group).
other
orally
administered
60
every
day
10
days
(GB+
increased
serum
creatinine
urea
levels,
MALAT1
expression,
addition
dysregulation
PI3K/Akt/mTOR
when
compared
normal
control
received
saline
only
(NC
Moreover,
damage
histopathologically
group.
ameliorated
reversed
changes
these
biochemical
analyses.
involvement
downregulation
expressions
were
firstly
molecular
mechanism
injury.
Journal of Cellular and Molecular Medicine,
Journal Year:
2021,
Volume and Issue:
25(11), P. 4922 - 4937
Published: May 3, 2021
Abstract
Long
non‐coding
RNA
(lncRNA)
lnc‐ISG20
has
been
found
aberrantly
up‐regulated
in
the
glomerular
patients
with
diabetic
nephropathy
(DN).
We
aimed
to
elucidate
function
and
regulatory
mechanism
of
lncRNA
on
DN‐induced
renal
fibrosis.
Expression
patterns
kidney
tissues
DN
were
determined
by
RT‐qPCR.
Mouse
models
constructed,
while
MCs
cultured
under
normal
glucose
(NG)/high
(HG)
conditions.
The
expression
fibrosis
marker
proteins
collagen
IV,
fibronectin
TGF‐β1
measured
Western
blot
assay.
In
addition,
relationship
among
lnc‐ISG20,
miR‐486‐5p,
NFAT5
AKT
analysed
using
dual‐luciferase
reporter
assay
immunoprecipitation.
effect
miR‐486/NFAT5/p‐AKT
axis
DN‐associated
was
also
verified
means
rescue
experiments.
levels
increased
patients,
mouse
HG‐treated
MCs.
Lnc‐ISG20
silencing
alleviated
HG‐induced
delayed
mice.
Mechanistically,
miR‐486‐5p
be
a
downstream
miRNA
inhibited
binding
its
3'UTR.
overexpression
aggravated
stimulating
phosphorylation.
However,
reversed
promotion
vitro
vivo
caused
overexpression.
Our
collective
findings
indicate
that
promotes
process
activating
through
miR‐486‐5p/NFAT5
axis.
High‐expression
may
useful
indicator
for
DN.
Chinese Medical Journal,
Journal Year:
2020,
Volume and Issue:
133(16), P. 1961 - 1970
Published: Aug. 15, 2020
Type
2
diabetes
mellitus
and
metabolic
disorders
have
become
an
epidemic
globally.
However,
the
pathogenesis
remains
largely
unclear
prevention
treatment
are
still
limited.
In
addition
to
environmental
factors
during
adulthood,
early
life
is
critical
developmental
window
with
high
tissue
plasticity,
which
might
be
modified
by
external
cues.
Substantial
evidence
has
demonstrated
vital
role
of
early-life
nutrition
in
programming
later
life.
this
review,
we
aim
overview
concepts
fetal
investigate
effects
on
energy
metabolism
potential
epigenetic
mechanism.
The
related
studies
published
PubMed
database
up
March
2020
were
included.
results
showed
that
both
maternal
overnutrition
undernutrition
increased
riskes
offspring
modifications,
including
DNA
methylation,
miRNAs,
histone
modification,
mediators.
beneficial
lifestyle
modifications
as
well
dietary
nutritional
interventions
these
deleterious
remolding
initially
observed.
Overall,
characterizing
malnutrition
reshapes
disease
trajectories
may
yield
novel
targets
for
intervention
provide
a
new
point
view
metabolism.
Frontiers in Genetics,
Journal Year:
2021,
Volume and Issue:
12
Published: July 27, 2021
Renal
fibrosis
(RF)
is
a
pathological
process
that
culminates
in
terminal
renal
failure
chronic
kidney
disease
(CKD).
Fibrosis
contributes
to
progressive
and
irreversible
decline
function.
However,
the
molecular
mechanisms
involved
RF
are
complex
remain
poorly
understood.
Long
non-coding
RNAs
(lncRNAs)
major
type
of
RNAs,
which
significantly
affect
various
processes,
cellular
homeostasis,
development
through
multiple
mechanisms.
Recent
investigations
have
implicated
aberrantly
expressed
lncRNA
progression,
suggesting
lncRNAs
play
crucial
role
determining
clinical
manifestation
RF.
In
this
review,
we
comprehensively
evaluated
recently
published
articles
on
RF,
discussed
potential
application
as
diagnostic
and/or
prognostic
biomarkers,
proposed
therapeutic
targets
for
treating
RF-associated
diseases
subsequent
CKD
transition,
highlight
future
research
directions
context
treatment
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
12
Published: March 13, 2025
LncRNAs
are
RNA
molecules
of
more
than
200
nucleotides
in
length
and
participate
cellular
metabolism
responses
through
their
diverse
interactomedespite
having
no
protein-coding
capabilities.
Such
significant
interactions
also
implicate
the
presence
lncRNAs
complex
pathobiological
pathways
various
diseases,
affecting
survival
by
modulating
autophagy,
inflammation
apoptosis.
Proliferating
cells
harbour
a
microenvironment
that
mainly
stimulate
growth-specific
activities
such
as
DNA
replication,
repair,
protein
synthesis.
They
recognise
damages
at
macromolecular
level,
preventing
them
from
reaching
next-generation.
have
shown
association
with
events
occurring
towards
proliferation,
regulating
key
dividing
cells,
dysregulation
lncRNA
transcriptome
affects
normal
life-cycle,
promoting
development
cancer.
Furthermore,
demonstrated
an
cancer
growth
progression
governing
cell
growth,
epithelial-mesenchymal
transition
metastasis.
This
makes
attractive
target
for
treatment
can
be
used
marker
diagnosis
prognosis
diseases
due
to
differential
expression
diseased
samples.
review
delves
into
correlation
fundamental
signalling
how
this
crosstalk
shapes
complexity
oncogenic
microhabitat.
Molecular Omics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Roxadustat
alters
serum
exosomal
mRNA–lncRNA
profiles
in
CKD.
These
findings
highlight
a
novel
regulatory
axis
linked
to
lipid
metabolism,
enhancing
treatment
assessment
for
