Mitochondrial Dysfunction: At the Nexus between Alcohol-Associated Immunometabolic Dysregulation and Tissue Injury DOI Open Access
Robert W. Siggins, Patrick M. McTernan, Liz Simon

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8650 - 8650

Published: May 12, 2023

Alcohol misuse, directly or indirectly as a result of its metabolism, negatively impacts most tissues, including four with critical roles in energy metabolism regulation: the liver, pancreas, adipose, and skeletal muscle. Mitochondria have long been studied for their biosynthetic roles, such ATP synthesis initiation apoptosis. However, current research has provided evidence that mitochondria participate myriad cellular processes, immune activation, nutrient sensing pancreatic β-cells, muscle stem progenitor cell differentiation. The literature indicates alcohol impairs mitochondrial respiratory capacity, promoting reactive oxygen species (ROS) generation disrupting dynamics, leading to dysfunctional accumulation. As discussed this review, dyshomeostasis emerges at nexus between alcohol-disrupted tissue injury. Here, we highlight link focus on alcohol-mediated disruption immunometabolism, which refers two distinct, yet interrelated processes. Extrinsic immunometabolism involves processes whereby cells products influence and/or metabolism. Intrinsic describes fuel utilization bioenergetics affect intracellular Alcohol-induced dysregulation cells, contributing This review will present state literature, describing metabolic immunometabolic from perspective.

Language: Английский

A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential DOI
Arkadiy Bazhin,

Riccardo Sinisi,

Umberto De Marchi

et al.

Nature Chemical Biology, Journal Year: 2020, Volume and Issue: 16(12), P. 1385 - 1393

Published: Aug. 10, 2020

Language: Английский

Citations

51
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2 DOI
Karthickeyan Chella Krishnan, Laurent Vergnes, Rebeca Acín‐Pérez

et al.

Nature Metabolism, Journal Year: 2021, Volume and Issue: 3(11), P. 1552 - 1568

Published: Oct. 25, 2021

Language: Английский

Citations

43
The Role of PKM2 in the Regulation of Mitochondrial Function: Focus on Mitochondrial Metabolism, Oxidative Stress, Dynamic, and Apoptosis. PKM2 in Mitochondrial Function DOI Creative Commons
Jing Gao, Yuwei Zhao, Tao Li

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 9

Published: May 6, 2022

The M2 isoform of pyruvate kinase (PKM2) is one (PK). PKM2 expressed at high levels during embryonic development and tumor progression subject to complex allosteric regulation. a special glycolytic enzyme that regulates the final step glycolysis; role in metabolism, survival, apoptosis cancer cells has received increasing attention. Mitochondria are directly or indirectly involved regulation energy susceptibility oxidative stress, cell death; however, mitochondrial functions remains unclear. Herein, we review related mechanisms from aspects reactive oxygen species (ROS), dynamic, apoptosis, which can be highlighted as target for clinical management cardiovascular metabolic diseases.

Language: Английский

Citations

31
Adaptations to a cold climate promoted social evolution in Asian colobine primates DOI
Xiao‐Guang Qi, Jinwei Wu, Lan Zhao

et al.

Science, Journal Year: 2023, Volume and Issue: 380(6648)

Published: June 1, 2023

The biological mechanisms that underpin primate social evolution remain poorly understood. Asian colobines display a range of organizations, which makes them good models for investigating evolution. By integrating ecological, geological, fossil, behavioral, and genomic analyses, we found colobine primates inhabit colder environments tend to live in larger, more complex groups. Specifically, glacial periods during the past 6 million years promoted selection genes involved cold-related energy metabolism neurohormonal regulation. More-efficient dopamine oxytocin pathways developed odd-nosed monkeys, may have favored prolongation maternal care lactation, increasing infant survival cold environments. These adaptive changes appear strengthened interindividual affiliation, increased male-male tolerance, facilitated stepwise aggregation from independent one-male groups large multilevel societies.

Language: Английский

Citations

19
Mitochondrial Dysfunction: At the Nexus between Alcohol-Associated Immunometabolic Dysregulation and Tissue Injury DOI Open Access
Robert W. Siggins, Patrick M. McTernan, Liz Simon

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 8650 - 8650

Published: May 12, 2023

Alcohol misuse, directly or indirectly as a result of its metabolism, negatively impacts most tissues, including four with critical roles in energy metabolism regulation: the liver, pancreas, adipose, and skeletal muscle. Mitochondria have long been studied for their biosynthetic roles, such ATP synthesis initiation apoptosis. However, current research has provided evidence that mitochondria participate myriad cellular processes, immune activation, nutrient sensing pancreatic β-cells, muscle stem progenitor cell differentiation. The literature indicates alcohol impairs mitochondrial respiratory capacity, promoting reactive oxygen species (ROS) generation disrupting dynamics, leading to dysfunctional accumulation. As discussed this review, dyshomeostasis emerges at nexus between alcohol-disrupted tissue injury. Here, we highlight link focus on alcohol-mediated disruption immunometabolism, which refers two distinct, yet interrelated processes. Extrinsic immunometabolism involves processes whereby cells products influence and/or metabolism. Intrinsic describes fuel utilization bioenergetics affect intracellular Alcohol-induced dysregulation cells, contributing This review will present state literature, describing metabolic immunometabolic from perspective.

Language: Английский

Citations

18