Schizophrenia Research, Journal Year: 2022, Volume and Issue: 246, P. 148 - 155
Published: June 29, 2022
Language: Английский
Neurosciences, Journal Year: 2025, Volume and Issue: 30(1), P. 5 - 19
Published: Jan. 1, 2025
The hippocampus, noted as (HC), plays a crucial role in the processes of learning, memory formation, and spatial navigation. Recent research reveals that this brain region can undergo structural functional changes due to environmental exposures, including stress, noise pollution, sleep deprivation, microgravity. This review synthesizes findings from animal human studies, emphasizing HC's plasticity response these factors. It examines volume, architecture, neurogenesis, synaptic plasticity, gene expression highlights critical periods vulnerability influences impacting cognition behavior. also investigates underlying mechanisms such glucocorticoid signaling, epigenetic alterations, neural circuit adaptations. Understanding how HC reacts various exposures is vital for developing strategies enhance cognitive resilience mitigate negative effects on region. Further needed identify protective risk factors create effective interventions.
Language: Английский
Citations
2
Life, Journal Year: 2022, Volume and Issue: 12(5), P. 638 - 638
Published: April 25, 2022
Glutamate neurotransmission and metabolism are finely modulated by the retinal network, where efficient processing of visual information is shaped differential distribution composition glutamate receptors transporters. However, disturbances in homeostasis can result excitotoxicity, a major initiating factor common neurodegenerative diseases. Within retina, excitotoxicity impair transmission degeneration neuronal populations, including ganglion cells (RGCs). The vulnerability RGCs observed not just as diseases but has also been ascribed to other peripheral In this review, we describe contribution different transporters this. particular, focus on
Language: Английский
Citations
54
Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13
Published: April 8, 2022
Depression is a global health problem with growing prevalence rates and serious impacts on the daily life of patients. However, side effects currently used antidepressants greatly reduce compliance Quercetin flavonol present in fruits, vegetables, Traditional Chinese medicine (TCM) that has been proved to have various pharmacological such as anti-depressant, anti-cancer, antibacterial, antioxidant, anti-inflammatory, neuroprotective. This review summarizes evidence for application quercetin treat depression. We clarified mechanisms regulating levels neurotransmitters, promoting regeneration hippocampal neurons, improving hypothalamic-pituitary-adrenal (HPA) axis dysfunction, reducing inflammatory states anti-oxidative stress. also summarized antidepressant some glycoside derivatives provide reference further research clinical application.
Language: Английский
Citations
53
Frontiers in Molecular Neuroscience, Journal Year: 2022, Volume and Issue: 14
Published: Jan. 7, 2022
Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal discharges, nerve conduction, neuron injury inflammation, thereby they may participate epileptogenesis. NMDARs belong to a family ionotropic glutamate essential roles excitatory neurotransmission synaptic plasticity mammalian CNS. Despite numerous focusing on NMDAR epilepsy, relationship appeared be elusive. In this article, we reviewed regulation possible mechanisms respect onset, development, treatment, trying provide more evidence for future studies.
Language: Английский
Citations
45
Neuromodulation Technology at the Neural Interface, Journal Year: 2022, Volume and Issue: 25(8), P. 1289 - 1298
Published: Jan. 3, 2022
Language: Английский
Citations
40
Neuroscience, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
1
Journal of Chemical Information and Modeling, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
N-Methyl-d-aspartate (NMDA) receptors, a subtype of ionotropic glutamate receptors in the central nervous system (CNS), have garnered attention for their role brain disorders. Specifically, GluN2A-containing NMDA emerged as potential therapeutic target treatment depressive disorders and epilepsy. However, development receptor-selective antagonists, represented by N-(4-(2-benzoylhydrazine-1-carbonyl)benzyl)-3-chloro-4-fluorobenzenesulfonamide (TCN-201) its derivatives, faces significant challenge due to limited ability penetrate blood-brain barrier (BBB), hampering vivo characterization further advancement. In this study, we reported series 2-((5-(phemylamino)-1,3,4-thiadiazol-2-yl)thio)-N-(cyclohexylmethyl)acetamide achieved through structure-guided optimization strategy using free energy perturbation (FEP) BBB permeability estimation. Through systematic exploration various phenyl substitutions, compound 1f standout compound, demonstrating substantially enhanced inhibitory activity compared with lead TCN-213. Compound not only displayed satisfactory but also showed antidepressant-like potency hydrocortisone-induced zebrafish depression-like model. All results position it promising candidate developing innovative therapeutics receptor-related
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(20), P. 10911 - 10911
Published: Oct. 9, 2021
Ovarian teratomas are by far the most common ovarian germ cell tumor. Most benign unless a somatic transformation occurs. The designation of teratoma refers to neoplasm that differentiates toward somatic-type populations. Recent research shows striking association between and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, rare understudied paraneoplastic neurological syndrome (PNS). Among teratomas, mature thought have greater relevance with those impairments. PNS is described as neurologic deficit triggered an underlying remote tumor, whereas anti-NMDAR encephalitis characterized complex neuropsychiatric presence autoantibodies in cerebral spinal fluid against GluN1 subunit NMDAR. This review aims summarize recent reports on teratoma. In particular, molecular pathway pathogenesis updated mechanism disease models would be discussed. We hope provide in-depth this issue and, therefore, better understand its epidemiology, diagnostic approach, treatment strategies.
Language: Английский
Citations
43
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10794 - 10794
Published: Sept. 16, 2022
The versatile roles of D-amino acids (D-AAs) in foods, diseases, and organisms, etc., have been widely reported. They regarded, not only as biomarkers diseases but also regulators the physiological function organisms. Over past few decades, increasing data has revealed that D-AAs great potential treating disease. showed overwhelming success disengaging biofilm, which might provide promise to inhibit microbial infection. Moreover, it can effectively restrain growth cancer cells. Herein, we reviewed recent reports on therapeutic agents for neurological disease or tissue/organ injury, ameliorating reproduction function, preventing biofilm infection, inhibiting cell growth. Additionally, application drug modification, such improving biostability efficiency, a better effect therapy diagnosis.
Language: Английский
Citations
31
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(10), P. 8188 - 8205
Published: March 13, 2024
Language: Английский
Citations
7