Recent advances in strategies to target the behavior of macrophages in wound healing

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115199 - 115199

Published: July 28, 2023

Chronic wounds and scar formation are widespread due to limited suitable remedies. The macrophage is a crucial regulator in wound healing, controlling the onset termination of inflammation regulating other processes related healing. current breakthroughs developing new medications drug delivery methods have enabled accurate targeting macrophages oncology rheumatic disease therapies through clinical trials. These successes cleared way utilize drugs various disorders. This review thus summarizes involvement normal pathologic It further details targets available for intervention therapeutic strategies behavior tissue repair regeneration.

Language: Английский

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Looking to the Future of the Role of Macrophages and Extracellular Vesicles in Neuroinflammation in ALS

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11251 - 11251

Published: July 8, 2023

Neuroinflammation is a common pathological feature of amyotrophic lateral sclerosis (ALS). Although scientific evidence to date does not allow defining neuroinflammation as an ALS trigger, its role in exacerbating motor neuron (MNs) degeneration and disease progression attracting research interest. Activated CNS (Central Nervous System) glial cells, proinflammatory peripheral infiltrated T lymphocytes monocytes/macrophages, well the immunoreactive molecules they release, represent active players for immune dysregulation enhancing neuroinflammation. The crosstalk between cells significantly correlates with survival patients since modification macrophages can downregulate inflammation at periphery along nerves CNS. As putative vehicles misfolded protein inflammatory mediators extracellular vesicles (EVs) have also drawn particular attention field ALS. Both release EVs, which are able modulate behavior neighboring recipient cells; unfortunately, mechanisms involved EVs-mediated communication remain unclear. This review aims synthesize current literature regarding EV-mediated cell-to-cell brain under ALS, point view on responding understand biological process exploit it management.

Language: Английский

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“Complimenting the Complement”: Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 10

Published: Feb. 24, 2021

Hepatocellular carcinoma (HCC) is the most common primary malignancy of liver and a leading cause death in US worldwide. HCC remains global health problem highly aggressive with unfavorable prognosis. Even surgical interventions newer medical treatment regimens, patients have poor survival rates. These limited therapeutic strategies mechanistic understandings immunopathogenesis urgently warrant non-palliative measures. Irrespective multitude etiologies, microenvironment intricately associated chronic necroinflammation, progressive fibrosis, cirrhosis as precedent events along dysregulated innate adaptive immune responses. Central to these immunological networks complement cascade (CC), fundamental defense system inherent which tightly regulates humoral cellular responses noxious stimuli. Importantly, source for biosynthesis >80% components expresses variety receptors. Recent studies implicate inflammation, abnormal regenerative responses, carcinogenesis, development HCC. Although activation differentially promotes immunosuppressive, stimulant, angiogenic microenvironments conducive development, it under-investigated. Here, we review derangement specific proteins context altered regulatory factors, immune-activating components, their implications disease pathogenesis. We also summarize how molecules regulate cancer stem cells (CSCs), interact complement-coagulation cascades, provide opportunities targeted intervention

Language: Английский

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The prognostic role of tumor associated macrophages in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis

Oral Oncology, Journal Year: 2022, Volume and Issue: 135, P. 106227 - 106227

Published: Nov. 3, 2022

Head and neck squamous cell carcinoma (HNSCC) is an immunogenic cancer type, tumor associated macrophages (TAMs) are a major component of the microenvironment (TME). In this systematic review meta-analysis, studies assessing infiltration with CD68+, iNOS+, HLA-DR+, CD11b+, CD163+, CD206+, CD204+TAMs were included, correlation to survival hazard was studied. A low number CD68+TAMs correlated better overall (OS) in multivariate analysis (HR 1.36 95 %CI (1.07-1.72) P = .01). did not correlate disease free (DFS), specific (DSS), progression (PFS), or recurrence (RFS). CD163+TAMs OS uni- (resp. HR 2.65 (1.57-4.46) .01 2.42 (1.72-3.41) < .001). also DFS PFS, whereas only PFS. While IHC pan macrophage marker CD68 M2-like CD163 both show prognostic utility OS, stronger prognosticator, as indicated by meta-analysis. PFS; outcomes that more relevant patients, thus showing promising results for future clinical implementation.

Language: Английский

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Radionuclide imaging and therapy directed towards the tumor microenvironment: a multi-cancer approach for personalized medicine

European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2022, Volume and Issue: 49(13), P. 4616 - 4641

Published: July 5, 2022

Abstract Targeted radionuclide theranostics is becoming more and prominent in clinical oncology. Currently, most nuclear medicine compounds researched for cancer are directed towards targets expressed only a small subset of types, limiting applicability. The identification cancer-specific that (more) universally will allow patients to benefit from these personalized medicine–based interventions. A tumor not merely collection cells, it also comprises supporting stromal cells embedded an altered extracellular matrix (ECM), together forming the microenvironment (TME). Since TME less genetically unstable than phenotypes can be shared between offers expressed. characterized by presence processes such as hypoxia, acidity, increased metabolism. Next ECM, consists cancer-associated fibroblasts (CAFs), macrophages, endothelial neo-vasculature, immune adipocytes (CAAs). Radioligands at processes, cellular components have been developed evaluated preclinical studies targeted imaging and/or therapy. In this review, we provide overview their corresponding radioligands. addition, discuss what developments needed further explore target theranostics, with hopes stimulating development novel radioligands multi-cancer, or some cases even pan-cancer, application.

Language: Английский

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