Experimental Neurology,
Journal Year:
2023,
Volume and Issue:
369, P. 114543 - 114543
Published: Sept. 23, 2023
Central
nervous
system
(CNS)
diseases
are
a
leading
cause
of
death
and
disability.
Due
to
CNS
neurons
have
no
self-renewal
regenerative
ability
as
they
mature,
their
loss
after
injury
or
disease
is
irreversible
often
leads
functional
impairments.
Unfortunately,
therapeutic
options
for
still
limited,
effective
treatments
these
notorious
warranted
be
explored.
At
present,
stem
cell
therapy
has
emerged
potential
strategy
improving
the
prognosis
diseases.
Accumulating
preclinical
clinical
evidences
demonstrated
that
multiple
molecular
mechanisms,
such
replacement,
immunoregulation
neurotrophic
effect,
underlie
use
However,
several
issues
yet
addressed
support
its
application.
Thus,
this
review
article
aims
summarize
role
underlying
mechanisms
in
treating
And
it
worthy
further
evaluation
applications
treatment
disease.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: April 3, 2024
Due
to
high
proliferative
capacity,
multipotent
differentiation,
immunomodulatory
abilities,
and
lack
of
ethical
concerns,
dental
pulp
stem
cells
(DPSCs)
are
promising
candidates
for
clinical
application.
Currently,
research
on
DPSCs
is
in
its
early
stages.
The
reason
the
failure
obtain
clinically
effective
results
may
be
problems
with
production
process
DPSCs.
different
preparation
methods
reagent
formulations
DPSCs,
cell
characteristics
affected
lead
inconsistent
experimental
results.
Preparation
clinical-grade
far
from
ready.
To
achieve
application,
it
essential
transit
manufacturing
laboratory
grade
grade.
This
review
compares
analyzes
data
optimizing
extraction
resuscitation,
including
articles,
invention
patents
trials.
advantages
disadvantages
various
potential
applications
discussed,
factors
that
could
improve
quality
application
proposed.
aim
summarize
current
manufacture
establishment
a
standardized,
reliable,
safe,
economic
method
future
products.
Experimental Neurology,
Journal Year:
2024,
Volume and Issue:
379, P. 114867 - 114867
Published: June 22, 2024
An
ischemic
stroke
(IS)
is
caused
due
to
the
lack
of
blood
flow
cerebral
tissue.
Most
studies
have
focused
on
how
affects
localized
tissue,
but
it
has
been
observed
that
a
can
cause
secondary
complications
in
distant
organs,
such
as
Bone
Marrow
(BM).
Our
study
effect
strokes
bone
marrow
microenvironment.
(BM)
vital
organ
maintains
inflammatory
homeostasis
and
aids
repair
damaged
tissue
after
injury/IS.
We
used
middle
artery
occlusion
(MCAO)
model
adult
mice
(6
months)
investigated
changes
BM
environment.
cells
were
for
western
blot
RT-PCR,
supernatant
was
cytokine
analysis
extracellular
vesicle
(EVs)
isolation.
significant
increase
total
cell
number
within
an
TNF-alpha
MCP-1,
which
are
known
inducing
pro-inflammatory
Western
blots
whole
lysate
demonstrated
elevated
levels
factors
(IL-6,
TNF-alpha,
TLR-4)
senescence
markers
(p21
p16).
EVs
isolated
from
showed
no
change
size
or
concentration;
however,
we
found
carried
increased
miRNA-141-3p
miRNA-34a.
Proteomic
BM-derived
alteration
protein
cargo
IS.
FgB,
C3,
Fn1,
Tra2b
levels.
The
signaling
pathway
mitochondrial
function
most
affected
marrow.
IS
induces
environment
secreted
BM.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4437 - 4437
Published: May 7, 2025
The
blood–brain
barrier
(BBB)
is
a
semi-permeable
membrane
in
physiological
conditions,
but
pathologies
like
multiple
sclerosis
(MS)
and
ischemic
stroke
(IS),
its
permeability
increases.
In
this
review,
we
focus
on
neutrophils
their
interaction
with
cellular
components
of
the
BBB:
endothelial
cells
(EC),
pericytes
(PC),
astrocytes
(AC).
Nowadays,
receive
more
attention,
mostly
due
to
advanced
research
techniques
that
show
complexity
population.
Additionally,
have
ability
secrete
extracellular
vesicles
(EVs),
reactive
oxygen
species
(ROS)
cytokines,
which
both
destroy
restore
BBB.
Astrocytes,
PCs,
ECs
also
dual
roles
pathogenesis
MS
IS.
between
BBB
provides
us
wider
insight
into
common
diseases
central
nervous
system.
Further,
comprehensively
review
knowledge
about
influence
context
Moreover,
describe
new
therapeutic
strategies
for
patients
IS
cell-based
therapies
use
neutrophil
function.
Experimental Neurology,
Journal Year:
2023,
Volume and Issue:
369, P. 114543 - 114543
Published: Sept. 23, 2023
Central
nervous
system
(CNS)
diseases
are
a
leading
cause
of
death
and
disability.
Due
to
CNS
neurons
have
no
self-renewal
regenerative
ability
as
they
mature,
their
loss
after
injury
or
disease
is
irreversible
often
leads
functional
impairments.
Unfortunately,
therapeutic
options
for
still
limited,
effective
treatments
these
notorious
warranted
be
explored.
At
present,
stem
cell
therapy
has
emerged
potential
strategy
improving
the
prognosis
diseases.
Accumulating
preclinical
clinical
evidences
demonstrated
that
multiple
molecular
mechanisms,
such
replacement,
immunoregulation
neurotrophic
effect,
underlie
use
However,
several
issues
yet
addressed
support
its
application.
Thus,
this
review
article
aims
summarize
role
underlying
mechanisms
in
treating
And
it
worthy
further
evaluation
applications
treatment
disease.
