Enhanced alleviation of insulin resistance via the IRS-1/Akt/FOXO1 pathway by combining quercetin and EGCG and involving miR-27a-3p and miR-96–5p

Free Radical Biology and Medicine, Journal Year: 2022, Volume and Issue: 181, P. 105 - 117

Published: Feb. 4, 2022

Language: Английский

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Downregulation of miR-410-3p via the METRNL-mediated AMPK/SIRT1/NF-κB signaling axis inhibits oxidative stress and inflammation in idiopathic pulmonary fibrosis

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111667 - 111667

Published: Feb. 1, 2025

Language: Английский

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The Antioxidant Transcription Factor Nrf2 in Cardiac Ischemia–Reperfusion Injury

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(21), P. 11939 - 11939

Published: Nov. 3, 2021

Nuclear factor erythroid-2 related 2 (Nrf2) is a transcription that controls cellular defense responses against toxic and oxidative stress by modulating the expression of genes involved in antioxidant response drug detoxification. In addition to maintaining redox homeostasis, Nrf2 also various processes including metabolism inflammation. activity tightly regulated at transcriptional, post-transcriptional post-translational levels, which allows cells quickly respond pathological stress. present review, we describe molecular mechanisms underlying transcriptional regulation Nrf2. We focus on impact cardiac ischemia-reperfusion injury, condition stimulates overproduction reactive oxygen species. Finally, analyze protective effect several natural synthetic compounds induce activation protect injury heart other organs, their potential clinical application.

Language: Английский

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Recent progress in epigenetics of obesity

Diabetology & Metabolic Syndrome, Journal Year: 2022, Volume and Issue: 14(1)

Published: Nov. 17, 2022

Abstract Nowadays, obesity is one of the largest public health problems worldwide. In last few decades, there has been a marked increase in epidemic and its related comorbidities. Worldwide, more than 2.2 billion people (33%) are affected by overweight or (712 million, 10%) associated metabolic complications. Although high heritability estimated, genetic variants conducted from association studies only partially explain variation body mass index. This led to growing interest understanding potential role epigenetics as key regulator gene-environment interactions on development Rapid advances epigenetic research methods reduced costs epigenome-wide have great expansion population-based studies. The field diseases such advanced rapidly short period time. main mechanisms include DNA methylation, histone modifications, microRNA (miRNA)-mediated regulation so on. methylation most investigated mechanism. Preliminary evidence animal human supports effect obesity. Studies genome-wide modifications different biological specimens blood samples (newborn, children, adolescent, youth, woman, man, twin, race, meta-analysis), adipose tissues, skeletal muscle cells, placenta, saliva reported differential expression status multiple genes before after interventions identified candidate markers. These findings may improve complex etiology comorbidities, help predict an individual’s risk at young age open possibilities for introducing targeted prevention treatment strategies.

Language: Английский

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Methionine restriction - Association with redox homeostasis and implications on aging and diseases

Redox Biology, Journal Year: 2022, Volume and Issue: 57, P. 102464 - 102464

Published: Sept. 8, 2022

Methionine is an essential amino acid, involved in the promotion of growth, immunity, and regulation energy metabolism. Over decades, research has long focused on beneficial effects methionine supplementation, while data positive restriction (MR) were first published 1993. MR a low-methionine dietary intervention that been reported to ameliorate aging aging-related health concomitants diseases, such as obesity, type 2 diabetes, cognitive disorders. In addition, seems be approach prolong lifespan which validated extensively various animal models, Caenorhabditis elegans, Drosophila, yeast, murine models. appears associated with reduction oxidative stress via so far mainly undiscovered mechanisms, these changes redox status appear one underlying mechanisms for extension effects. present review, association metabolism pathways homeostasis described. lifespan, age-related implications, comorbidities, diseases are discussed.

Language: Английский

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Hormesis and Oxidative Distress: Pathophysiology of Reactive Oxygen Species and the Open Question of Antioxidant Modulation and Supplementation

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1613 - 1613

Published: Aug. 19, 2022

Alterations of redox homeostasis leads to a condition resilience known as hormesis that is due the activation redox-sensitive pathways stimulating cell proliferation, growth, differentiation, and angiogenesis. Instead, supraphysiological production reactive oxygen species (ROS) exceeds antioxidant defence oxidative distress. This induces damage biomolecules responsible or co-responsible for onset several chronic pathologies. Thus, dietary supplementation has been proposed in order prevent aging, cardiovascular degenerative diseases well carcinogenesis. However, this approach failed demonstrate efficacy, often leading harmful side effects, particular patients affected by cancer. In latter case, an based on endogenous depletion, ROS overproduction, shown interesting potential enhancing susceptibility anticancer therapies. Therefore, deep investigation molecular involved balance crucial identify new targets useful development more effective therapeutic approaches. The review herein provides overview pathophysiological role focuses attention positive negative aspects modulation with intent find insights successful clinical application.

Language: Английский

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Role of Long Non-Coding RNAs and the Molecular Mechanisms Involved in Insulin Resistance

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(14), P. 7256 - 7256

Published: July 6, 2021

Long non-coding RNAs (lncRNAs) are single-stranded RNA biomolecules with a length of >200 nt, and they currently considered to be master regulators many pathological processes. Recent publications have shown that lncRNAs play important roles in the pathogenesis progression insulin resistance (IR) glucose homeostasis by regulating inflammatory lipogenic regulate gene expression binding other RNAs, mRNAs, proteins, DNA. In recent years, several mechanisms been reported explain key development IR, including metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), imprinted maternal-ly expressed (H19), maternally 3 (MEG3), myocardial infarction-associated (MIAT), steroid receptor activator (SRA), HOX antisense (HOTAIR), downregulated Expression-Related Hexose/Glucose Transport Enhancer (DREH). LncRNAs participate regulation lipid carbohydrate metabolism, process, oxidative stress through different pathways, such as cyclic adenosine monophosphate/protein kinase A (cAMP/PKA), phosphatidylinositol 3-kinase/protein B (PI3K/AKT), polypyrimidine tract-binding protein 1/element-binding transcription factor 1c (PTBP1/SREBP-1c), AKT/nitric oxide synthase (eNOS), AKT/forkhead box O1 (FoxO1), tumor necrosis factor-alpha (TNF-α)/c-Jun-N-terminal kinases (JNK). On hand, linked molecular, cellular, biochemical actions vary according tissue, biological species, severity IR. Therefore, it is essential elucidate role signaling pathway metabolism. This review analyzes function molecular involved

Language: Английский

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Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node

Frontiers in Aging Neuroscience, Journal Year: 2021, Volume and Issue: 13

Published: Sept. 20, 2021

The intracellular energy state will alter under the influence of physiological or pathological stimuli. In response to this change, cells usually mobilize various molecules and their mechanisms promote stability status. Mitochondria are main source ATP. Previous studies have found that function mitochondria is impaired in aging, neurodegenerative diseases, metabolic damaged bring lower ATP production, which further worsens progression disease. Silent information regulator-1 (SIRT1) a multipotent molecule participates regulation important biological processes cells, including cellular metabolism, cell senescence, inflammation. review, we mainly discuss promoting expression activity SIRT1 contributes alleviating stress produced by conditions. review also discusses mechanism precise dimensions. Finally, according characteristics recovery mitochondrial function, relationship between current pharmacological preparations other diseases was analyzed.

Language: Английский

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An insight into PI3k/Akt pathway and associated protein–protein interactions in metabolic syndrome: A recent update

Journal of Cellular Biochemistry, Journal Year: 2023, Volume and Issue: 124(7), P. 923 - 942

Published: July 1, 2023

Akt, a known serine/threonine-protein kinase B has been revealed to be an imperative protein of the PI3K/Akt pathway. Akt is available in three isoforms, Akt1, Akt2, and Akt3. Ubiquitously expressed Akt1 & Akt2 are essential for cell survival believed involved regulating glucose homeostasis. pathway evidenced associated with metabolic diseases viz. hypertension, dyslipidemia, diabetes. interacting proteins have scaffold Notably, some protein-protein interactions inhibition or uncontrolled activation these signaling pathways. For instance, binds other namely, FOXO1 mTOR, play key role onset progression syndrome (MS). The purpose this review highlight which might serve as valuable tool investigators develop new promising therapeutic agents management MS.

Language: Английский

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Visceral Adipose Tissue of Prediabetic and Diabetic Females Shares a Set of Similarly Upregulated microRNAs Functionally Annotated to Inflammation, Oxidative Stress and Insulin Signaling

Antioxidants, Journal Year: 2021, Volume and Issue: 10(1), P. 101 - 101

Published: Jan. 12, 2021

Hypertrophic and hypoxic visceral adipose tissue (VAT) secretes proinflammatory cytokines promoting insulin resistance (IR), prediabetes type 2 diabetes (T2DM) microRNAs (miRNAs) are markers of metabolic disorders regulating genes critical for e.g., inflammation, glucose metabolism, antioxidant defense, with raising diagnostic value. The aim the current study was to evaluate whether hyperglycemia is able affect expression selected miRNAs in VAT prediabetic (IFG) diabetic patients vs. normoglycemic (NG) subjects using qPCR. Statistical analyses suggested that could be sex-dependent. Thus, we determined 15 as differentially expressed (DE) among NG, T2DM, IFG females (miR-10a-5p, let-7d-5p, miR-532-5p, miR-127-3p, miR-125b-5p, let-7a-5p, let-7e-5p, miR-199a-3p, miR-365a-3p, miR-99a-5p, miR-100-5p, miR-342-3p, miR-146b-5p, miR-204-5p, miR-409-3p). Majority significantly changed similarly upregulated female T2DM comparison NG subjects, positively correlated FPG HbA1c, yet, uncorrelated WHR/BMI. Enrichment indicated involvement 11 top DE oxidative stress, inflammation signaling. Those changes possibly associated low-grade chronic stress hyperglycemic subjects.

Language: Английский

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