The chronic unpredictable mild stress (CUMS) Paradigm: Bridging the gap in depression research from bench to bedside

Brain Research, Journal Year: 2024, Volume and Issue: 1843, P. 149123 - 149123

Published: Nov. 1, 2024

Language: Английский

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Presenilin: A Multi-Functional Molecule in the Pathogenesis of Alzheimer’s Disease and Other Neurodegenerative Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1757 - 1757

Published: Feb. 1, 2024

Presenilin, a transmembrane protein primarily known for its role in Alzheimer’s disease (AD) as part of the γ-secretase complex, has garnered increased attention due to multifaceted functions various cellular processes. Recent investigations have unveiled plethora beyond amyloidogenic role. This review aims provide comprehensive overview presenilin’s diverse roles AD and other neurodegenerative disorders. It includes summary well-known substrates presenilin, such involvement amyloid precursor (APP) processing Notch signaling, along with functions. Additionally, it highlights newly discovered functions, trafficking function, regulation ferritin expression, apolipoprotein E (ApoE) secretion, interaction ApoE Aβ42-to-Aβ40-converting activity ACE. updated perspective underscores evolving landscape presenilin research, emphasizing broader impact established pathways. The incorporation these novel findings accentuates dynamic nature processes, further advancing our comprehension By synthesizing evidence from range studies, this sheds light on intricate web their implications health disease.

Language: Английский

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The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical applications

Pharmacological Research, Journal Year: 2024, Volume and Issue: 201, P. 107090 - 107090

Published: Feb. 2, 2024

Depression is a major global health issue that urgently requires innovative and precise treatment options. In this context, saikosaponin has emerged as promising candidate, offering variety of therapeutic benefits may be effective in combating depression. This review delves into the multifaceted potential saikosaponins alleviating depressive symptoms. We summarized effects on structural functional neuroplasticity, elaborated regulatory mechanism modulating key factors affect such inflammation, hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, brain-gut axis. Moreover, paper highlights existing gaps current researches outlines directions for future studies. A detailed plan provided clinical application saikosaponins, advocating more targeted to speed up its transition from preclinical trials practice.

Language: Английский

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Curcumin Improves Neurogenesis in Alzheimer’s Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5123 - 5123

Published: May 8, 2024

Adult neurogenesis in the dentate gyrus (DG) is impaired during Alzheimer's disease (AD) progression. Curcumin has been reported to reduce cell apoptosis and stimulate neurogenesis. This study aimed investigate influence of curcumin on adult AD mice its potential mechanism. Two-month-old male C57BL/6J were injected with soluble β-amyloid (Aβ1-42) using lateral ventricle stereolocalization establish models. An immunofluorescence assay, including bromodeoxyuridine (BrdU), doublecortin (DCX), neuron-specific nuclear antigen (NeuN), was used detect hippocampal Western blot an enzyme-linked immunosorbent assay (ELISA) test expression related proteins secretion brain-derived neurotrophic factor (BDNF). A Morris water maze cognitive function mice. Our results showed that administration (100 mg/kg) rescued Aβ1-42 mice, shown as enhanced BrdU+/DCX+ BrdU+/NeuN+ cells DG. In addition, regulated phosphatidylinositol 3 kinase (PI3K)/protein B (Akt) -mediated glycogen synthase kinase-3β (GSK3β) /Wingless/Integrated (Wnt)/β-catenin pathway cyclic adenosine monophosphate response element-binding protein (CREB)/BDNF Inhibiting Wnt/β-catenin depriving BDNF could reverse both upregulated curcumin-treated conclusion, our indicates curcumin, through targeting PI3K/Akt, regulates GSK3β/Wnt/β-catenin CREB/BDNF pathways, improving

Language: Английский

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DPP-4 inhibition by linagliptin ameliorates age-related mild cognitive impairment by regulating microglia polarization in mice

Experimental Neurology, Journal Year: 2024, Volume and Issue: 373, P. 114689 - 114689

Published: Jan. 8, 2024

Language: Английский

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