A Randomized, Double-Blind, Placebo-Controlled Study of an Anthocyanin-Rich Functional Ingredient on Cognitive Function and Eye Dryness in Late Adulthood Volunteers: Roles of Epigenetic and Gut Microbiome Modulations

Nutrients, Journal Year: 2023, Volume and Issue: 15(16), P. 3499 - 3499

Published: Aug. 8, 2023

Due to the rising demand for supplements targeting cognitive enhancement and dry eye together with health benefits of anthocyanins, we have developed a functional soup containing an anthocyanin-rich ingredient, or "Anthaplex," assessed effects on function dryness possible mechanisms. A total 69 male female volunteers were randomized divided into placebo, D2, D4 groups. All subjects consumed 120 mL placebo "Anthaplex" either at 2 4 g per serving day within 5 min in morning eight weeks. The function, working memory, eye, AChE, MAO, MAO-A, MAO-B, GABA-T activities, BDNF, HAC, HDAC, DNMT pH, amount lactic acid-producing bacteria, particularly

Language: Английский

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Gut dysbiosis in autoimmune diseases: Association with mortality

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: March 31, 2023

To better understand the impact of gut dysbiosis on four autoimmune diseases [Sjögren’s syndrome (SS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS)], this review investigated altered bacteria in each disease shared ones among diseases. The enriched by three were Streptococcus , Prevotella Eggerthella which are associated with autoantibody production or activation Th17 cells immune-related On other hand, Faecalibacterium comprises depleted patients SLE, MS, SS, is various anti-inflammatory activities. indexes dysbiosis, defined as number bacterial taxa divided studies RA, 1.7, 1.8, 0.7, 1.3, respectively. Interestingly, these values presented a positive correlation trend standardized mortality rates —2.66, 2.89, 1.54, 1.41, In addition, may correlate prevalence polyautoimmunity that is, 41 percent, 32.6 14 1–16.6 Overall, suggests be closely related to failure immune system maintain homeostasis.

Language: Английский

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The Autoimmune Rheumatic Disease Related Dry Eye and Its Association with Retinopathy

Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 724 - 724

Published: April 23, 2023

Dry eye disease is a chronic of the ocular surface characterized by abnormal tear film composition, instability, and inflammation, affecting 5% to 50% population worldwide. Autoimmune rheumatic diseases (ARDs) are systemic disorders with multi-organ involvement, including eye, play significant role in dry eye. To date, most studies have focused on Sjögren’s syndrome (one ARDs) since it manifests as two common symptoms–dry eyes mouth-and attracts physicians explore relationship between ARDs. Many patients complained related symptoms before they were diagnosed ARDs, malaise sensitive indicator severity In addition, ARD also associated some retinal directly or indirectly, which described this review. This review summarizes incidence, epidemiological characteristics, pathogenesis, accompanying lesions ARD’s emphasizing potential recognition monitoring among ARDs patients.

Language: Английский

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The gut-retina axis: a new perspective in the prevention and treatment of diabetic retinopathy

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: July 4, 2023

Diabetic retinopathy (DR) is a microvascular lesion that occurs as complication of diabetes mellitus. Many studies reveal retinal neurodegeneration early in its pathogenesis, and abnormal function can occur patients without any signs abnormalities. The gut microbiota large, diverse colony microorganisms colonize the human intestine. Studies indicated involved pathophysiological processes DR plays an important role development. On one hand, numerous demonstrated involvement neurodegeneration. other alterations bacteria RD cause or exacerbate DR. present review aims to underline critical relationship between After brief overview composition, function, essential ocular health, explores concept gut-retina axis conditions crosstalk. Because dysbiosis has been associated with DR, intends determine changes microbiome hypothesized mechanisms linking axis, predictive potential.

Language: Английский

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Unveiling the gut-eye axis: how microbial metabolites influence ocular health and disease

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: May 10, 2024

The intricate interplay between the gut microbiota and ocular health has surpassed conventional medical beliefs, fundamentally reshaping our understanding of organ interconnectivity. This review investigates into relationship microbiota-derived metabolites their consequential impact on disease pathogenesis. By examining role specific metabolites, such as short-chain fatty acids (SCFAs) like butyrate bile (BAs), herein we elucidate significant contributions to pathologies, thought-provoking traditional belief sterility, particularly in field ophthalmology. Highlighting dynamic nature its profound influence health, this underlines necessity comprehending complex workings gut-eye axis, an emerging science ready for further exploration scrutiny. While acknowledging therapeutic promise manipulating microbiome available literature advocates a targeted, precise approach. Instead broad interventions, it emphasizes potential exploiting microbiome-related focused strategy. targeted approach compared precision tool rather than broad-spectrum solution, aims explore applications context various retinal diseases. proposing nuanced strategy at microbial suggests that addressing deficiencies or imbalances through might yield expedited pronounced outcomes systemic extending eye. holds bypassing irregularity associated with microbes themselves, paving more efficient pathway toward desired optimizing implications

Language: Английский

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Association between aging-dependent gut microbiome dysbiosis and dry eye severity in C57BL/6 male mouse model: a pilot study

BMC Microbiology, Journal Year: 2021, Volume and Issue: 21(1)

Published: April 9, 2021

Abstract Background While aging is a potent risk factor of dry eye disease, age-related gut dysbiosis associated with inflammation and chronic geriatric diseases. Emerging evidence have demonstrated that contributes to the pathophysiology or exacerbation ocular diseases including disease. However, relationship between aging-related changes in microbiota disease has not been elucidated. In this pilot study, we investigated association aging-dependent microbiome severity C57BL/6 male mice. Results Eight-week-old (8 W, n = 15), one-year-old (1Y, 10), two-year-old (2Y, 8) mice were used. Dry was assessed by corneal staining scores tear secretion. Bacterial genomic 16 s rRNA from feces analyzed. Main outcomes compositional differences among groups their correlation severity. aged (1Y 2Y), increased secretion decreased statistical significance. Gut α-diversity different groups. β-diversity significantly univariate analysis, phylum Firmicutes , Proteobacteria, Cyanobacteria / Bacteroidetes ratio, genus Alistipes Bacteroides Prevotella Paraprevotella Helicobacter related After adjustment age, multivariate analysis revealed Proteobacteria Lactobacillus be Conclusions Our study suggests composition are signs

Language: Английский

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The Impact of Probiotics and Prebiotics on Dry Eye Disease Signs and Symptoms

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(16), P. 4889 - 4889

Published: Aug. 20, 2022

Dry eye is considered an inflammatory disease. Gut microbiota are important in the regulation of low-grade chronic inflammation, including eye. Probiotics and prebiotics increasingly used to regulate chronic-disease-associated gut dysbiosis. Therefore, this double-masked, randomized controlled clinical trial aimed explore potential oral probiotics management dry In total, 41 participants with received probiotic prebiotic supplements (treatment group, n = 23) or respective placebos (control 18) for 4 months. symptoms signs were evaluated using Ocular Surface Disease Index (OSDI), Eye Questionnaire 5, osmolarity, non-invasive keratograph break-up time (NIKBUT), ocular surface staining, tear meniscus height (TMH), lipid layer thickness, conjunctival redness. After months, average OSDI score treatment group was significantly better compared that controls (16.8 ± 5.9 vs. 23.4 7.4; p < 0.001). The NIKBUT TMH did not change (p 0.31 0.84) but reduced on by −5.5 1.0 secs 0.03) 0.2 0.1 mm 0.02). These data suggest might be effective

Language: Английский

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Gut Dysbiosis in Ocular Mucous Membrane Pemphigoid

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: April 14, 2022

Mucous Membrane Pemphigoid is an orphan multi-system autoimmune scarring disease involving mucosal sites, including the ocular surface (OcMMP) and gut. Loss of tolerance to epithelial basement membrane proteins generation autoreactive T cell and/or autoantibodies are central process. The gut microbiome plays a critical role in development immune system. Alteration (gut dysbiosis) affects cells B autoantibody repertoire several conditions. This study examines relationship between diversity inflammation patients with OcMMP by comparing profiles healthy controls. DNA was extracted from faecal samples (49 patients, 40 controls), amplified for V4 region 16S rRNA gene sequenced using Illumina Miseq platform. Sequencing reads were processed bioinformatics pipeline available mothur v.1.44.1 software. After adjusting participant factors multivariable model (age, gender, BMI, diet, proton pump inhibitor use), cohort found be associated lower number operational taxonomic units (OTUs) Shannon Diversity Index when compared Within cohort, OTUs significantly correlated both bulbar conjunctival score (p=0.03) current use systemic immunotherapy (p=0.02). linear discriminant analysis effect size scores indicated that Streptococcus Lachnoclostridium enriched whilst Oxalobacter, Clostridia uncultured genus-level group (UCG) 014, Christensenellaceae R-7 butyrate-producing bacteria such as Ruminococcus, Lachnospiraceae, Coprococcus, Roseburia, Oscillospiraceae UCG 003, 005, NK4A214 controls (Log10 LDA < 2, FDR-adjusted p <0.05). In conclusion, have dysbiosis correlating immunotherapies. provides framework future longitudinal deep phenotyping studies on pathogenesis OcMMP.

Language: Английский

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Novel treatments for dry eye syndrome

Current Opinion in Pharmacology, Journal Year: 2024, Volume and Issue: 75, P. 102431 - 102431

Published: Jan. 25, 2024

Language: Английский

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The Gut–Eye Axis: Correlation Between the Gut Microbiota and Autoimmune Dry Eye in Individuals With Sjögren Syndrome

Eye & Contact Lens Science & Clinical Practice, Journal Year: 2022, Volume and Issue: 49(1), P. 1 - 7

Published: Nov. 11, 2022

Abstract: The impact of gut microbiota on human health, autoimmunity, and disease occurrence has long been recognized since the advancement metagenomic sequencing technology enabled a new level perspective microbiome. Emerging findings also suggest existence gut–eye axis, wherein dysbiosis may be crucial factor affecting onset progression multiple ocular diseases. Sjögren syndrome (SS) is chronic autoimmune mainly exocrine glands, primarily lacrimal gland in eye, resulting severe dry eye. Although there are currently various treatments for environmental efficacy SS-related eye limited, more effective therapies still need to explored. latest studies have demonstrated that plays key role pathogenesis This review describes effect surface eye; introduces presumable pathways forming “gut dysbiosis–ocular surface–lacrimal axis”; discusses advantages restoring intestinal microecology treat by fecal transplantation or probiotics, which expected provide perspectives into correlation between microbiome enhance our understanding useful development future interventions regulating microbiota.

Language: Английский

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