Treatment of Pseudomonas aeruginosa infectious biofilms: Challenges and strategies DOI Creative Commons
Rui Yin,

Juanli Cheng,

Jingyao Wang

et al.

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 26, 2022

Pseudomonas aeruginosa , a Gram-negative bacterium, is one of the major pathogens implicated in human opportunistic infection and common cause clinically persistent infections such as cystic fibrosis, urinary tract infections, burn infections. The main reason for persistence P. due to ability secrete extracellular polymeric substances exopolysaccharides, matrix proteins, DNA during invasion. These adhere wrap around bacterial cells form biofilm. Biofilm formation leads multiple antibiotic resistance posing significant challenge conventional single therapeutic approaches. It has therefore become particularly important develop anti-biofilm drugs. In recent years, number new alternative drugs have been developed treat infectious biofilms, including antimicrobial peptides, quorum-sensing inhibitors, bacteriophage therapy, photodynamic therapy. This article briefly introduces process regulation biofilm reviews several treatment technologies provide directions infection.

Language: Английский

Skeletal infections: microbial pathogenesis, immunity and clinical management DOI Open Access
Elysia A. Masters, Benjamin F. Ricciardi, Karen L. de Mesy Bentley

et al.

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 20(7), P. 385 - 400

Published: Feb. 15, 2022

Language: Английский

Citations

358
Biofilms: Understanding the structure and contribution towards bacterial resistance in antibiotics DOI Creative Commons

Pallee Shree,

Chandra Kant Singh, Kushneet Kaur Sodhi

et al.

Medicine in Microecology, Journal Year: 2023, Volume and Issue: 16, P. 100084 - 100084

Published: May 31, 2023

The biofilm is a bacterial colony wrapped in an auto-produced polymer matrix of polysaccharides, proteins, and DNA. Bacterial biofilms cause persistent infections because they are more resistant to antibiotics, disinfectants, the immune system body. Other significant characteristics gradient oxygen nutrition from top layer bottom biofilms. Lower cell metabolic activity longer doubling rates linked gradients; these quiescent cells responsible for some resistance antibiotics. Biofilms may be avoided cured with vigorous antibiotic prophylaxis or treatment early on continuous suppressive medication. This review discusses development tolerance bacteria due formation, mechanisms, that induce bacteria. Recent strategies combat also discussed.

Language: Английский

Citations

159
Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance DOI Creative Commons
Chongbing Liao, Xin Huang, Qingxia Wang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: July 6, 2022

is an opportunistic pathogen causing nosocomial infections in severely ill and immunocompromised patients. Ubiquitously disseminated the environment, especially hospitals, it has become a major threat to human health due constant emergence of drug-resistant strains. Multiple resistance mechanisms are exploited by

Language: Английский

Citations

158
Biofilm Formation and Control of Foodborne Pathogenic Bacteria DOI Creative Commons
Xiaoli Liu, Huaiying Yao,

Xihong Zhao

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2432 - 2432

Published: March 7, 2023

Biofilms are microbial aggregation membranes that formed when microorganisms attach to the surfaces of living or nonliving things. Importantly, biofilm properties provide with protection against environmental pressures and enhance their resistance antimicrobial agents, contributing persistence toxicity. Thus, bacterial formation is part survival mechanism. However, if foodborne pathogens form biofilms, risk disease infections can be greatly exacerbated, which cause major public health risks lead adverse economic consequences. Therefore, research on biofilms removal strategies very important in food industry. Food waste due spoilage within industry remains a global challenge sustainability security supplies. This review describes formation, elaborates problem associated industry, enumerates several kinds common summarizes current used eliminate control harmful introduces emerging strategies, emphasizes future development prospects respect biofilms.

Language: Английский

Citations

121
Bacterial Biofilms and Their Implications in Pathogenesis and Food Safety DOI Creative Commons

Xingjian Bai,

Cindy H. Nakatsu, Arun K. Bhunia

et al.

Foods, Journal Year: 2021, Volume and Issue: 10(9), P. 2117 - 2117

Published: Sept. 8, 2021

Biofilm formation is an integral part of the microbial life cycle in nature. In food processing environments, bacterial transmissions occur primarily through raw or undercooked foods and by cross-contamination during unsanitary preparation practices. Foodborne pathogens form biofilms as a survival strategy various unfavorable which also become frequent source recurrent contamination outbreaks foodborne illness. Instead focusing on biofilm their pathogenicity individually, this review discusses molecular level how these two physiological processes are connected several common such Listeria monocytogenes, Staphylococcus aureus, Salmonella enterica Escherichia coli. addition, Pseudomonas aeruginosa discussed because it aids persistence many forming polymicrobial contact surfaces, thus significantly elevating safety public health concerns. Furthermore, in-depth analyses molecules with dual functions highlighted.

Language: Английский

Citations

117
Biofilm formation and inhibition mediated by bacterial quorum sensing DOI
Yingsong Wang, Zeran Bian, Yan Wang

et al.

Applied Microbiology and Biotechnology, Journal Year: 2022, Volume and Issue: 106(19-20), P. 6365 - 6381

Published: Sept. 12, 2022

Language: Английский

Citations

113
Symbiosis of microalgae and bacteria consortium for heavy metal remediation in wastewater DOI
Dehua Zhao, Wai Yan Cheah, Sai Hin Lai

et al.

Journal of environmental chemical engineering, Journal Year: 2023, Volume and Issue: 11(3), P. 109943 - 109943

Published: April 17, 2023

Language: Английский

Citations

85
Pseudomonas aeruginosa reference strains PAO1 and PA14: A genomic, phenotypic, and therapeutic review DOI Creative Commons

Amber Grace,

Rajnish Sahu,

Donald R. Owen

et al.

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 13, 2022

Pseudomonas aeruginosa is a ubiquitous, motile, gram-negative bacterium that has been recently identified as multi-drug resistant pathogen in critical need of novel therapeutics. Of the approximately 5,000 strains, PAO1 and PA14 are common laboratory reference modeling moderately hyper-virulent phenotypes, respectively. have instrumental facilitating discovery drug targets, testing therapeutics, supplying genomic information on bacterium. While two strains contributed to wide breadth knowledge natural behaviors therapeutic susceptibilities P. aeruginosa, they demonstrated significant deviations from observations human infections. Many these related experimental inconsistencies strain environment complicate and, at times, terminate translation results clinical applications. This review aims provide comparative analysis potential methods improve their relevance.

Language: Английский

Citations

80
Evaluation of Antibiotic Resistance Mechanisms in Gram-Negative Bacteria DOI Creative Commons

Anusha Gauba,

Khondaker Miraz Rahman

Antibiotics, Journal Year: 2023, Volume and Issue: 12(11), P. 1590 - 1590

Published: Nov. 3, 2023

Multidrug-resistant Gram-negative bacterial infections are exponentially increasing, posing one of the most urgent global healthcare and economic threats. Due to lack new therapies, World Health Organization classified these species as priority pathogens in 2017, known ESKAPE pathogens. This classification emphasizes need for research development novel targeted therapies. The majority species, which possess a structurally dynamic cell envelope enabling them resist multiple antibiotics, thereby leading increased mortality rates. Despite 6 years having passed since WHO classification, progress generating treatment ideas has not been sufficient, antimicrobial resistance continues escalate, acting ticking time bomb. Numerous efforts strategies have employed combat rising levels antibiotic by targeting specific mechanisms. These mechanisms include inactivating/modifying enzymes, outer membrane porin remodelling, enhanced efflux pump action, alteration target sites. Some demonstrated clinical promise, such utilization beta-lactamase inhibitors adjuvants, well recent advancements machine-based learning employing artificial intelligence facilitate production narrow-spectrum antibiotics. However, further into an understanding precise occurs, specifically tailored each could pave way exploring review aims introduce key features bacteria their current approaches, summarizing major with focus on Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae. Additionally, potential directions alternative therapies will be discussed, along relative modes providing future perspective insight discipline resistance.

Language: Английский

Citations

76
Pseudomonas aeruginosa’s greenish-blue pigment pyocyanin: its production and biological activities DOI Creative Commons
Ahmed Abdelaziz,

Amal M. Abo Kamer,

Khaled B. Al-Monofy

et al.

Microbial Cell Factories, Journal Year: 2023, Volume and Issue: 22(1)

Published: June 8, 2023

Abstract A subject of great interest is the bioprospecting microorganisms and their bioactive byproducts, such as pigments. Microbial pigments have various benefits, including being safe to use due natural makeup, having therapeutic effects, produced all year round, regardless weather or location. Pseudomonas aeruginosa produces phenazine that are crucial for interactions between species other living things. Pyocyanin pigment, which synthesized by 90–95% P. , has potent antibacterial, antioxidant, anticancer properties. Herein, we will concentrate on production extraction pyocyanin pigment its biological in different areas biotechnology, engineering, biology.

Language: Английский

Citations

60