Neurotoxicology and Teratology, Journal Year: 2023, Volume and Issue: 98, P. 107181 - 107181
Published: May 11, 2023
Exposure to perfluoroalkyl substances (PFAS) has been shown be neurotoxic in experimental studies, but epidemiological evidence linking prenatal PFAS exposure child neurodevelopment is equivocal and scarce.
Language: Английский
Environment International, Journal Year: 2021, Volume and Issue: 157, P. 106843 - 106843
Published: Aug. 31, 2021
Epidemiological studies have shown Per- and polyfluoroalkyl substances (PFAS) to be associated with diseases of dysregulated lipid sterol homeostasis such as steatosis cardiometabolic disorders. However, the majority mechanistic rely on single chemical exposures instead identifying mechanisms related toxicity PFAS mixtures. The goal current study is investigate linking exposure a mixture alterations in metabolism, including increased circulating cholesterol bile acids. Male female wild-type C57BL/6J mice were fed an atherogenic diet used previous pollutant-accelerated atherosclerosis exposed water containing 5 representing legacy, replacement, alternative subtypes (i.e., PFOA, PFOS, PFNA, PFHxS, GenX), each at concentration 2 mg/L, for 12 weeks. Changes transcriptome metabolome level determined by RNA-seq high-resolution mass spectrometry, respectively. We observed cholesterol, metabolites, acids due exposure, some sexual dimorphic effects. hepatic injury, demonstrated liver weight, inflammation, plasma alanine aminotransferase levels. Females displayed lobular portal inflammation compared male PFAS-exposed mice. Hepatic transcriptomics analysis revealed modulated multiple metabolic pathways, those sterols, acids, acyl carnitines, sex-specific differences observed. Finally, we show that levels PFOA females males, but this dimorphism was not same other examined. Exposure results PFAS-mediated modulation levels, possibly through disruption enterohepatic circulation.
Language: Английский
Citations
205
The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 859, P. 160010 - 160010
Published: Nov. 8, 2022
Language: Английский
Citations
138
npj Clean Water, Journal Year: 2023, Volume and Issue: 6(1)
Published: Aug. 21, 2023
Abstract Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), known as the most detected per- polyfluoroalkyl substances (PFAS) in various environmental compartments, have been associated with plastic pollution endocrine dysfunction. Over past 180 years (1839–2019), numerous emerging contaminants identified, PFOA PFOS receiving considerable attention based on scientific evidence publications. Between 2018 2019, experienced a relatively high increase rate of 18.8% 13.6%, respectively. While developed countries made progress establishing stringent guidelines, developing underdeveloped often lack regulations mechanisms to address PFAS. Furthermore, advancements PFAS removal technologies are needed improve their efficacy feasibility. The establishment regulatory compliances, along exposure assessment risk characterization, is essential for providing precautionary advice water source protection, supply security, health risks, treatment efficiency, contamination forecasting. However, more comprehensive approach database evaluating risks still imperative effectively combat drinking water. Therefore, this review aims enhance monitoring management practices response global crisis contamination. analysis Needs, Approaches, Benefits, Challenges (NABC) grounded current trends environment human through
Language: Английский
Citations
121
Frontiers in Endocrinology, Journal Year: 2021, Volume and Issue: 12
Published: July 9, 2021
Polyfluoro- and perfluoro–alkyl substances (PFAS) are organic chemicals extensively used worldwide for industry consumer products. Due to their chemical stability, PFAS represent a major cause of environmental pollution. accumulate in animal human blood tissues exerting toxicity. We performed review the epidemiological studies exploring relationship between exposure thromboembolic cardiovascular disease. An increase disease or death related has been reported from cross-sectional longitudinal observational with evidence concerning relation early vascular lesions atherosclerosis. Several indicate an alteration lipid glucose metabolism disorders increased pressure as possible link events. also examined recent indicating that legacy new can be incorporated platelet cell membranes giving solid rationale observed risk events populations exposed by directly promoting thrombus formation. Exposure altered plasma membrane fluidity associated calcium signal response agonists, both vitro ex vivo subjects PFAS. All functional responses platelets incorporation PFAS: adhesion, aggregation, microvesicles release experimental These findings offer mechanistic support hypothesis platelet-centred mechanisms may implicated chronically
Language: Английский
Citations
110
Neurotoxicology and Teratology, Journal Year: 2023, Volume and Issue: 97, P. 107174 - 107174
Published: March 11, 2023
Language: Английский
Citations
70
Archives of Toxicology, Journal Year: 2023, Volume and Issue: 97(5), P. 1195 - 1245
Published: March 22, 2023
Language: Английский
Citations
47
International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(21), P. 6984 - 6984
Published: Oct. 27, 2023
Some types of per- and poly-fluoroalkyl substances (PFAS) have been banned over the last two decades, but millions Americans continue to exposure compounds through drinking water consumer products. Therefore, understanding changes in serum PFAS concentrations after their limited use is necessary protect public health. In this study, we evaluated trends (PFOS, PFOA, PFHxS, PFDA, PFNA) determine distribution among United States general population. We analyzed measured from random subsamples National Health Nutrition Examination Survey (NHANES) participants. The study results demonstrated that demographic factors such as race/ethnicity, age, sex may influence levels time. Adults, males, Asians, Non-Hispanic Blacks, Whites had high risks selected PFAS. Overall, declined continuously studied population 1999 2018. Among population, PFOS PFDA were most least prevalent blood serum, respectively. Serum PFHxS showed upward at one racial/ethnic group 2016, which underscores need for continuous biomonitoring humans environment.
Language: Английский
Citations
45
Land Degradation and Development, Journal Year: 2024, Volume and Issue: 35(8), P. 2700 - 2715
Published: April 3, 2024
Abstract Soil and groundwater contamination has always been a global concern. Contaminants are migrated transformed in the soil environments, which turn pose potential environmental risks to humans. This paper describes four typical contaminants, including heavy metals, polycyclic aromatic hydrocarbons, microplastics, perfluorinated polyfluoroalkyl substances. Based on systematic summary of sources, hazards, migration behaviors these various existing remediation methods analyzed, advantages disadvantages different discussed. Finally, future research prospects described, significance study contaminant subsurface environment is emphasized. can help provide theoretical technical support for removal further improve rate actual sites.
Language: Английский
Citations
32
Case Studies in Chemical and Environmental Engineering, Journal Year: 2024, Volume and Issue: 9, P. 100623 - 100623
Published: Jan. 14, 2024
Alarming concern over the persistence and toxicity of per- polyfluoroalkyl substances (PFAS) in environment has created an imperative need for designing redesigning strategies their detection remediation. Conventional PFAS removal technologies that uses physical, chemical, or biological methods. Increase diversity quantity entering necessitated developing more advanced integrated removal. Despite advances reported this domain, there exist a huge research gap to be mentored tackle problems associated with mitigation combined wide variety environment. The possibility combine other emerging contaminants poses additional threat existing treatment methods thereby stressing continuous monitoring updating processes. This review work aims at understanding structure, entry, fate different types Further in-depth discussion regarding levels is elaborated review. process description recent remediation techniques along significance, limitations integration discussed detail. detailed outlook on advantages insight into recently developed outlined
Language: Английский
Citations
26
Pollutants, Journal Year: 2024, Volume and Issue: 4(1), P. 136 - 152
Published: March 6, 2024
Per- and polyfluoroalkyl substances (PFAS) belong to a group of synthetic compounds that have recently raised concerns about human health environmental quality due their great prevalence, degradation resistance, potential toxicity. This review focuses on the applications PFAS effects health. Specific emphasis has been laid (i) application/use PFAS, (ii) sources distribution in diverse compartments, (iii) impact Significant humans are associated with exposure i.e., immunotoxicity, thyroid kidney disorders, cancer, etc. Conclusions obtained from studies demonstrate inadequate evidence should not be used justify delaying risk reduction steps for alternatives. can determined different matrices using both traditional analytical approaches, liquid chromatography coupled mass spectrometry (LC-MS/MS) semi-quantitative passive sampling, advanced methods colorimetric, spectrofluorimetric, electrochemical detection. Traditional costly broadly available, while emerging, cost-effective less sensitive unable meet regulatory limits. There is still significant number performed fully comprehend real contamination by PFAS.
Language: Английский
Citations
20