British Journal of Hospital Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 12
Published: March 16, 2025
Aims/Background
As
a
common
chronic
respiratory
disease,
asthma
may
lead
to
airway
inflammation
and
accelerated,
progressive
loss
of
lung
function,
if
not
well
controlled,
posing
risks
patients’
life
health.
This
study
evaluates
the
impact
education
program
on
enhancing
control,
quality
life,
pulmonary
function
in
children,
addressing
gaps
existing
management
approaches.
Methods
In
this
retrospective
study,
60
patients
who
had
undergone
routine
nursing
mode
at
Beijing
Shijitan
Hospital
affiliated
Capital
Medical
University
from
May
2022
2023
were
enrolled
for
reference
group;
after
excluding
3
patients,
finally
included
57
patients.
Separately,
55
attended
child-oriented
basis
care
same
hospital
2024
observation
2
eventually
53
The
Childhood
Asthma
Control
Test
(C-ACT)
score,
Pediatric
Quality
Life
Questionnaire
(PAQLQ)
index
levels
measured
terms
percentage
predicted
forced
vital
capacity
(FVC%),
peak
expiratory
flow
(PEF),
one
second/forced
(FEV1/FVC),
disappearance
time
clinical
symptoms
(dyspnea,
chest
tightness,
cough,
wheezing)
compared
between
two
groups.
Results
Before
management,
there
no
differences
C-ACT
PAQLQ
scores
groups
(p
>
0.05).
After
group
significantly
higher
than
those
<
0.001).
There
FVC%,
PEF,
FEV1/FVC
before
such
as
dyspnea,
cough
wheezing
was
shorter
that
Conclusion
is
beneficial
disease
children
with
asthma,
improving
indexes,
shortening
symptom
disappearance.
Journal of Immunology Research,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 25
Published: March 26, 2022
Interleukins
(ILs)—which
are
important
members
of
cytokines—consist
a
vast
group
molecules,
including
wide
range
immune
mediators
that
contribute
to
the
immunological
responses
many
cells
and
tissues.
ILs
immune-glycoproteins,
which
directly
growth,
activation,
adhesion,
differentiation,
migration,
proliferation,
maturation
cells;
subsequently,
they
involved
in
pro
anti-inflammatory
body,
by
their
interaction
with
receptors.
Due
importance
system
different
organisms,
genes
belonging
elements,
such
as
ILs,
have
been
studied
vigorously.
The
results
recent
investigations
showed
pertaining
undergo
progressive
evolution
constant
rate.
occurrence
any
mutation
or
polymorphism
IL
may
result
substantial
changes
biology
function
be
associated
diseases
disorders.
Among
these
abnormalities,
single
nucleotide
polymorphisms
(SNPs)
can
represent
disruptive
factors.
present
review
aims
at
concisely
summarizing
current
knowledge
available
on
occurrence,
properties,
role,
biological
consequences
SNPs
within
IL-1
family
members.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(1), P. 173 - 173
Published: Jan. 12, 2024
Common
inflammatory
ground
links
obesity,
insulin
resistance,
and
asthma.
As
recognition
of
their
interplay,
one
worsening
the
natural
course
other,
is
recognised,
questions
remain
about
how
to
adequately
address
them
altogether
improve
clinical
outcomes.
The
present
manuscript
sheds
light
on
problem,
describing
possible
pathophysiological
links,
views,
therapeutic
challenges,
raising
what
remains
be
done,
calling
for
multidisciplinary
treatment
these
patients
detect
diseases
early
before
they
become
full-blown
deteriorate
health
quality
life.
Cells,
Journal Year:
2023,
Volume and Issue:
12(9), P. 1326 - 1326
Published: May 6, 2023
Asthma
is
a
chronic
complex
pulmonary
disease
characterized
by
airway
inflammation,
remodeling,
and
hyperresponsiveness.
Vascular
endothelial
growth
factor
(VEGF)
eosinophil-derived
neurotoxin
(EDN)
are
two
significant
mediators
involved
in
the
pathophysiology
of
asthma.
In
asthma,
VEGF
EDN
levels
elevated
correlate
with
severity
Diversity
polymorphisms
results
variability
responses
to
glucocorticosteroids
leukotriene
antagonist
treatment.
Targeting
eosinophils
promising
therapeutic
approach
for
We
identified
lichochalcone
A,
bevacizumab,
azithromycin
(AZT),
vitamin
D,
diosmetin,
epigallocatechin
gallate,
IGFBP-3,
Neovastat
(AE-941),
endostatin,
PEDF,
melatonin
as
putative
add-on
drugs
asthma
anti-VEGF
properties.
Further
studies
clinical
trials
needed
evaluate
efficacy
those
drugs.
AZT
reduces
exacerbation
rate
may
be
considered
adults
persistent
symptomatic
However,
long-term
effects
on
community
microbial
resistance
require
further
investigation.
Vitamin
D
supplementation
enhance
corticosteroid
responsiveness.
Herein,
anti-eosinophil
reviewed.
Among
them
are,
e.g.,
anti-IL-5
(mepolizumab,
reslizumab,
benralizumab),
anti-IL-13
(lebrikizumab
tralokinumab),
anti-IL-4
(dupilumab),
anti-IgE
(omalizumab)
over
peripheral
blood
eosinophil
count
recommended
monitor
control
status
assess
therapy
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(14), P. 3278 - 3278
Published: July 24, 2023
Considered
to
be
of
greater
complexity
than
the
human
genome
itself,
microbiome,
structure
body
made
up
trillions
bacteria,
viruses,
and
fungi,
has
proven
play
a
crucial
role
in
context
development
pathological
processes
body,
starting
from
various
infections,
autoimmune
diseases,
atopies,
culminating
its
involvement
some
forms
cancer,
diagnosis
that
is
considered
most
disabling
for
patient
psychological
point
view.
Therefore,
being
cornerstone
understanding
optimal
treatment
multitude
ailments,
body’s
microbiome
become
an
intensively
studied
subject
scientific
literature
last
decade.
This
review
aims
bring
microbiome–asthma
correlation
date
by
classifying
asthmatic
patterns,
emphasizing
patterns
perinatal
period
impact
pulmonary
dysbiosis
on
symptoms
children.
Likewise,
effects
intestinal
reflected
at
level
homeostasis
internal
environment
through
intestine–lung/vital
organs
axis,
circumstances
which
it
occurs,
but
also
main
methods
studying
bacterial
variability
used
diagnostic
purposes
research
should
not
omitted.
In
conclusion,
we
draw
current
future
therapeutic
lines
worthy
consideration
both
obtaining
maintaining
remission,
as
well
delaying
primary
acute
episodes
preventing
relapses.
Children,
Journal Year:
2024,
Volume and Issue:
11(5), P. 581 - 581
Published: May 11, 2024
Asthma,
a
prevalent
chronic
respiratory
condition
affecting
millions
of
children
globally,
presents
significant
health
challenge.
This
review
critically
examines
the
developmental
pathways
asthma
in
children,
focusing
on
genetic,
environmental,
and
early-life
determinants.
Specifically,
we
explore
impact
prenatal
postnatal
factors
such
as
maternal
smoking,
nutrition,
infections,
allergen
exposure
development.
Our
analysis
highlights
intricate
interplay
these
influences
their
contribution
to
childhood
asthma.
Moreover,
emphasize
targeted
strategies
interventions
mitigate
its
burden,
including
genetic
counseling
for
at-risk
families,
environmental
modifications
reduce
triggers,
immunomodulation.
By
delving
into
preventive
measures
interventions,
our
aims
provide
actionable
insights
healthcare
professionals
developing
tailored
address
complexities
In
summary,
this
article
offers
detailed
examination
development
aiming
enhance
understanding
inform
efforts
burden
through
interventions.
Cells,
Journal Year:
2022,
Volume and Issue:
11(5), P. 819 - 819
Published: Feb. 26, 2022
The
anti-thymic
stromal
lymphopoietin
antibody
(tezepelumab)
has
therapeutical
potential
for
inadequately
controlled
asthma.
However,
evidence
comparing
tezepelumab
with
other
biologics
is
scarce.
To
address
this
issue,
we
performed
a
network
meta-analysis
to
compare
and
rank
the
efficacy
of
five
treatments
(tezepelumab,
dupilumab,
benralizumab,
mepolizumab,
placebo)
in
overall
participants
subgroups
stratified
by
thresholds
type
2
inflammatory
biomarkers,
including
peripheral
blood
eosinophil
count
(PBEC)
fractional
exhaled
nitric
oxide
(FeNO).
primary
endpoints
were
annualized
exacerbation
rate
(AER)
any
adverse
events
(AAEs).
In
ranking
assessment
using
surface
under
cumulative
curve
(SUCRA)
AER,
ranked
highest
across
(based
on
PBEC
FeNO
level
thresholds).
A
significant
difference
was
observed
between
dupilumab
patient
subgroup
<
150,
benralizumab
≥
300
≥150,
respectively.
There
no
incidence
AAEs
each
pair
treatment
arms.
These
results
provide
basis
development
strategies
asthma
may
guide
basic,
clinical,
or
translational
research.
Frontiers in Allergy,
Journal Year:
2022,
Volume and Issue:
3
Published: April 29, 2022
Asthma
is
characterized
by
an
increase
in
the
contraction
and
inflammation
of
airway
muscles,
resulting
airflow
obstruction.
The
prevalence
asthma
lower
females
than
males
until
start
puberty,
higher
adult
women
men.
This
sex
disparity
switch
at
onset
puberty
has
been
object
debate
among
many
researchers.
Hence,
this
review,
we
have
summarized
these
observations
to
pinpoint
areas
needing
more
research
work
provide
better
sex-specific
diagnosis
management
asthma.
While
some
researchers
attributed
it
anatomical
physiological
differences
male
female
respiratory
systems,
influences
hormonal
interplay
after
also
stressed.
Other
hormones
such
as
leptin
linked
both
obese
non-obese
patients.
Recently,
scientists
demonstrated
influence
genomic
framework
a
key
player,
others
environmental,
social
lifestyle,
occupational
exposures.
majority
studies
concluded
that
men
are
less
susceptible
developing
display
severe
forms
disease.
Therefore,
understanding
roles
played
sex-
gender-specific
factors,
biological
mechanisms
involved
will
help
develop
novel
accurate
diagnostic
therapeutic
plans
for
management.
