Recent Advances and Mechanistic Insights into Antibacterial Activity, Antibiofilm Activity, and Cytotoxicity of Silver Nanoparticles

ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(4), P. 1391 - 1463

Published: March 31, 2022

The substantial increase in multidrug-resistant (MDR) pathogenic bacteria is a major threat to global health. Recently, the Centers for Disease Control and Prevention reported possibilities of greater deaths due bacterial infections than cancer. Nanomaterials, especially small-sized (size ≤10 nm) silver nanoparticles (AgNPs), can be employed combat these deadly diseases. However, high reactivity, instability, susceptibility fast oxidation, cytotoxicity remain crucial shortcomings their uptake clinical application. In this review, we discuss various AgNPs-based approaches eradicate provide comprehensive mechanistic insights recent advances antibacterial activity, antibiofilm (both vitro vivo) AgNPs. antimicrobial activity involves four steps: (i) adhesion AgNPs cell wall/membrane its disruption; (ii) intracellular penetration damage; (iii) oxidative stress; (iv) modulation signal transduction pathways. Numerous factors affecting bactericidal such as shape, size, crystallinity, pH, surface coating/charge have also been described detail. review sheds light on photodynamic therapy role versus Ag+ ions release activities. addition, different methods synthesis discussed brief.

Language: Английский

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Applications of Gold and Silver Nanoparticles in Theranostics

Applied Biochemistry and Biotechnology, Journal Year: 2022, Volume and Issue: 194(9), P. 4187 - 4219

Published: May 13, 2022

Language: Английский

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Emerging Trends in Advanced Translational Applications of Silver Nanoparticles: A Progressing Dawn of Nanotechnology

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(1), P. 47 - 47

Published: Jan. 14, 2023

Nanoscience has emerged as a fascinating field of science, with its implementation in multiple applications the form nanotechnology. Nanotechnology recently been more impactful diverse sectors such pharmaceutical industry, agriculture sector, and food market. The peculiar properties which make nanoparticles an asset are their large surface area size, ranges between 1 100 nanometers (nm). Various technologies, chemical biological processes, being used to synthesize nanoparticles. green chemistry route become extremely popular due use synthesis Nanomaterials versatile different day applications, resulting increased utilization distribution human cells, tissues, organs. Owing deployment at high demand, need produce raised concerns regarding environmentally friendly processes. These processes meant nanomaterials improved physiochemical that can have significant uses fields medicine, physics, biochemistry. Among plethora nanomaterials, silver most investigated nanoparticle. Silver (AgNPs) vital entities study distinctive scientific society aims investigate of. current review addresses modern expansion AgNP synthesis, characterization, mechanism, well global AgNPs limitations.

Language: Английский

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Silver Nanoparticles in Dental Applications: A Descriptive Review

Bioengineering, Journal Year: 2023, Volume and Issue: 10(3), P. 327 - 327

Published: March 5, 2023

Silver nanoparticles have been a recent focus of many researchers in dentistry, and their potential uses benefits drawn attention dentistry medicine. The fabrication utilization nanoscale substances structures are at the core rapidly developing areas nanotechnology. They often used dental industry because they prevent bacteria from making nanoparticles, oxides, biofilms. also stop metabolism bacteria. (AgNPs) type zero-dimensional material with different shapes. Dentistry has to keep up changing patient needs new technology. can be for disinfection preventing infections oral cavity. One most interesting metallic biomedical applications is silver (AgNPs). field found promising elimination plaque tartar, as well bacterial fungal mouth. incorporation AgNPs into materials shown significantly enhance patients’ health, leading widespread use. This review focuses on AgNP synthesis, chemical properties, biocompatibility, various fields, biomaterials dentistry. With an emphasis aspects related inclusion this descriptive paper intends address developments

Language: Английский

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Use of Antimicrobial Nanoparticles for the Management of Dental Diseases

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(3), P. 209 - 209

Published: Jan. 28, 2025

Dental diseases represent a significant global health concern, with traditional treatment methods often proving costly and lacking in long-term efficacy. Emerging research highlights nanoparticles as promising, cost-effective therapeutic alternative, owing to their unique properties. This review aims provide comprehensive overview of the application antimicrobial antioxidant management dental diseases. Silver gold have shown great potential for inhibiting biofilm formation thus preventing caries, gingivitis, periodontitis. Various products can integrate copper nanoparticles, known properties, combat oral infections. Similarly, zinc oxide enhance performance materials, including adhesives cements. Titanium dioxide cerium possess photocatalytic rendering them advantageous materials hygiene products. Chitosan are effective pathogens reducing inflammation periodontal tissues. Additionally, curcumin antimicrobial, anti-inflammatory, overall care Incorporating these diverse into holds significantly reduce risk infection, control formation, improve health. underscores importance continued development this promising field realize full care.

Language: Английский

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Green synthesis of silver nanoparticles using neem and turmeric extract and its antimicrobial activity of plant mediated silver nanoparticles

Journal of Oral Biology and Craniofacial Research, Journal Year: 2025, Volume and Issue: 15(2), P. 395 - 401

Published: Feb. 17, 2025

Language: Английский

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Antimicrobial Properties of Metal Nanoparticles and Their Oxide Materials and Their Applications in Oral Biology

Journal of Nanomaterials, Journal Year: 2022, Volume and Issue: 2022(1)

Published: Jan. 1, 2022

Some scholars have shown that metal nanoparticles excellent antibacterial properties and can be used as a new type of agent. In recent years, with the in‐depth research on nanomaterials, its applications in medical field gradually increased. The oral cavity has unique anatomical structure, for infections, current clinically commonly treatment measures are or topical antibiotics. However, due to bacterial resistance special structure dental plaque, effect antibiotics is not ideal. Metal oxide become hotspot materials their small particles, large specific surface area, physical, mechanical, chemical properties, properties. This article describes effect, mechanism, biological toxicity, application progress nanomaterials cavity.

Language: Английский

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Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 715 - 715

Published: Feb. 21, 2023

The efficient elimination of microorganisms and their byproducts from infected root canals is compromised by the limitations in conventional canal disinfection strategies antimicrobials. Silver nanoparticles (AgNPs) are advantageous for disinfection, mainly due to wide-spectrum anti-microbial activity. Compared other commonly used nanoparticulate antibacterials, AgNPs have acceptable antibacterial properties relatively low cytotoxicity. Owing nano-scale, penetrate deeper into complexities systems dentinal tubules, as well enhancing endodontic irrigants sealers. gradually increase dentin hardness endodontically treated teeth promote when a carrier intracanal medication. unique make them an ideal additive different biomaterials. However, possible side effects AgNPs, such cytotoxicity tooth discoloration potential, merits further research.

Language: Английский

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Emerging Applications of Nanotechnology in Dentistry

Dentistry Journal, Journal Year: 2023, Volume and Issue: 11(11), P. 266 - 266

Published: Nov. 15, 2023

Dentistry is a branch of healthcare where nanobiotechnology reverberating in multiple ways to produce beneficial outcomes. The purpose this review bring into the awareness readers various practical dimensions nano-dental complex (nanodentistry) and how novelties linked with field are revolutionizing dentistry. A methodological approach was adopted collect latest data on nanotechnology dentistry from sources, including PubMed, Google Scholar, Scopus, official websites like WHO. Nanodentistry an emerging that involves use nanomaterials, nanorobots, diagnose, treat, prevent dental diseases. results summarize descriptive analyses uses nanodentistry within orthodontics, preventive dentistry, prosthodontics, restorative periodontics, surgeries, restoration technologies, other areas future directions nano-industries nano-healthcare have been included link them oral sector, treatment plans, improved medical services which could be explored for advanced regulation. major limitations nanoproducts their cost-effectiveness accessibility, especially financially constrained countries. These will help experience detailed analysis comprehensive covering diverse achievements past analyses, present scenarios, implications.

Language: Английский

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Bioresponsive nanotechnology in pediatric dental drug delivery

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 93, P. 105436 - 105436

Published: Feb. 1, 2024

Nanotechnology in the field of pediatric dentistry offers innovative solutions to challenges. In this literature review, nanomaterials application dentistry, addressing critical concerns, such as toxicity and regulatory hurdles, is discussed. Also, unique physicochemical properties nanomaterials, including size, biocompatibility, drug delivery capabilities are explored. The safety efficacy nanoscale therapeutics were found be before their use dentistry. Polymer-based systems, especially those using natural polysaccharides, demonstrate great potential prevalent dental issues children. These systems can perform targeted therapy, reduce dosages, minimize side effects, making them beneficial for addition, future personalized treatments While advantages applying nanotechnology readily apparent, ongoing research should performed maximize its address

Language: Английский

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