Metabolic reprogramming of pulmonary fibrosis DOI Creative Commons
Jiaxin Li,

Xiaoxuan Zhai,

Xiao Sun

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 14, 2022

Pulmonary fibrosis is a progressive and intractable lung disease with fibrotic features that affects alveoli elasticity, which leading to higher rates of hospitalization mortality worldwide. initiated by repetitive localized micro-damages the alveolar epithelium, subsequently triggers aberrant epithelial-fibroblast communication myofibroblasts production in extracellular matrix, resulting massive matrix accumulation interstitial remodeling. The major cell types responsible for pulmonary are myofibroblasts, epithelial cells, macrophages, endothelial cells. Recent studies have demonstrated metabolic reprogramming or dysregulation these cells exerts their profibrotic role via affecting pathological mechanisms such as autophagy, apoptosis, aging, inflammatory responses, ultimately contributes development fibrosis. This review summarizes recent findings on occur aforementioned during fibrosis, especially those associated glucose, lipid, amino acid metabolism, aim identifying novel treatment targets

Language: Английский

Novel drug delivery systems and disease models for pulmonary fibrosis DOI
Rui Li,

Yizhen Jia,

Xiaohan Kong

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 348, P. 95 - 114

Published: June 3, 2022

Language: Английский

Citations

62
Role of DAMPs in respiratory virus-induced acute respiratory distress syndrome—with a preliminary reference to SARS-CoV-2 pneumonia DOI Creative Commons
W. Land

Genes and Immunity, Journal Year: 2021, Volume and Issue: 22(3), P. 141 - 160

Published: June 17, 2021

When surveying the current literature on COVID-19, "cytokine storm" is considered to be pathogenetically involved in its severe outcomes such as acute respiratory distress syndrome, systemic inflammatory response and eventually multiple organ failure. In this review, similar role of DAMPs addressed, that is, those molecules, which operate upstream pathway by activating cells, ultimately release cytokines. Given still limited reports their emerging topic extended viral infections with focus influenza. At first, a brief introduction given function various classes counterbalancing suppressing (SAMPs) initiating controlled inflammation-promoting inflammation-resolving defense responses upon infectious sterile insults. It stressed excessive emission injury uncovers fateful property triggering dysregulated life-threatening hyperinflammatory responses. Such scenario may happen when load too high, for example, tract, "forcing" many virus-infected host cells decide commit "suicidal" regulated cell death (e.g., necroptosis, pyroptosis) associated large amounts DAMPs: an important review. Ironically, although aim save restore organismal homeostasis, intrinsic leads responses—as typically pathogenesis syndrome infections. Consequently, briefly outlined these molecules can valuable diagnostic prognostic biomarkers monitor evaluate course disorder, particular, grasp eventual transition precociously from observed mild/moderate cases seen, severe/fatal COVID-19. Moreover, pathogenetic involvement qualifies them relevant future therapeutic targets prevent severe/ fatal outcomes. Finally, theory presented proposing superimposition coronavirus-induced non-virus-induced other origins air pollution or high age contribute courses coronavirus pneumonia.

Language: Английский

Citations

61
Different Methods to Improve the Monitoring of Noninvasive Respiratory Support of Patients with Severe Pneumonia/ARDS Due to COVID-19: An Update DOI Open Access
Paolo Pelosi, Roberto Tonelli, Chiara Torregiani

et al.

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(6), P. 1704 - 1704

Published: March 19, 2022

The latest guidelines for the hospital care of patients affected by coronavirus disease 2019 (COVID-19)-related acute respiratory failure have moved towards widely accepted use noninvasive support (NIRS) as opposed to early intubation at pandemic onset. establishment severe COVID-19 pneumonia goes through different pathophysiological phases that partially resemble typical distress syndrome (ARDS) and been categorized into clinical–radiological phenotypes. These can variably benefit on application external positive end-expiratory pressure (PEEP) during mechanical ventilation, mainly due variable levels lung recruitment ability compliance disease. A growing body evidence suggests intense effort producing excessive negative pleural swings (Ppl) plays a critical role in onset progression diaphragm damage treated with support. Routine monitoring is mandatory avoid nasty continuation NIRS who are higher risk deterioration could from initiation invasive ventilation instead. Here we propose methods both clinical experimental settings adapted this purpose, although further research required allow their extensive practice. We reviewed needs available tools clinical–physiological aims optimizing ventilatory management coronavirus-2 (SARS-CoV-2) infection.

Language: Английский

Citations

61
An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19) DOI
Reza Elahi,

Parsa Karami,

Amir Hossein Heidary

et al.

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 105, P. 108536 - 108536

Published: Jan. 11, 2022

Language: Английский

Citations

45
Immunotherapy of inflammatory bowel disease (IBD) through mesenchymal stem cells DOI

Huldani Huldani,

Ria Margiana, Fawad Ahmad

et al.

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 107, P. 108698 - 108698

Published: March 17, 2022

Language: Английский

Citations

41
Acute lung injury caused by sepsis: how does it happen? DOI Creative Commons
Baisheng Sun, M. Lei, Jiaqi Zhang

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Nov. 21, 2023

Sepsis is a systemic inflammatory disease caused by severe infections that involves multiple organs, among which the lung most susceptible, leaving patients highly vulnerable to acute injury (ALI). Refractory hypoxemia and respiratory distress are classic clinical symptoms of ALI sepsis, has mortality rate 40%. Despite extensive research on mechanisms exact pathological process not fully understood. This article reviews advances in pathogenesis sepsis focusing treatment regimens adopted practice for corresponding molecular mechanisms. review can only contribute theories but also recommend new strategies related injuries.

Language: Английский

Citations

41
Mucus Hypersecretion in Chronic Obstructive Pulmonary Disease and Its Treatment DOI Creative Commons
Binay Kumar Shah, Bivek Singh, Y Wang

et al.

Mediators of Inflammation, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 15

Published: July 6, 2023

Most patients diagnosed with chronic obstructive pulmonary disease (COPD) present hallmark features of airway mucus hypersecretion, including cough and expectoration. Airway function as a native immune system the lung that severs to trap particulate matter pathogens allows them clear from via ciliary transport. Chronic hypersecretion (CMH) is main factor contributing increased risk morbidity mortality in specific subsets COPD patients. It is, therefore, primarily important develop medications suppress hypersecretions these Although there have been some advances treatment, more work remains be done better understand mechanism underlying seek effective treatments. This review article discusses structure significance lungs focusing on gel-forming mucins impacts CMH lungs. Furthermore, we summarize pharmacological nonpharmacological treatments well novel interventional procedures control

Language: Английский

Citations

25
The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review DOI Creative Commons
Bowen Zhou,

Huaman Liu,

Fei Xu

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 9, 2024

Abstract Pulmonary fibrosis (PF) is a progressive interstitial inflammatory disease with high mortality rate. Patients PF commonly experience chronic dry cough and dyspnoea for years without effective mitigation. The pathogenesis of believed to be associated dysfunctional macrophage polarization, fibroblast proliferation, the loss epithelial cells. Thus, it great importance necessity explore interactions among macrophages, fibroblasts, alveolar cells in lung fibrosis, as well pro-fibrotic microenvironment. In this review, we discuss latest studies that have investigated polarization activation non-immune context progression. Next, how profibrotic cellular crosstalk promoted microenvironment by multiple cytokines, chemokines, signalling pathways. And finally, potential mechanisms fibrogenesis development efficient therapeutic strategies disease. Herein, provide comprehensive summary vital role its fibroblasts suggest treatment target their communication

Language: Английский

Citations

16
Repair and regeneration of the alveolar epithelium in lung injury DOI
Yaxuan Wang, Lan Wang, Shuaichen Ma

et al.

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(8)

Published: April 22, 2024

Considerable progress has been made in understanding the function of alveolar epithelial cells a quiescent state and regeneration mechanism after lung injury. Lung injury occurs commonly from severe viral bacterial infections, inhalation injury, indirect sepsis. A series pathological mechanisms caused by excessive such as apoptosis, autophagy, senescence, ferroptosis, have studied. Recovery requires integrity cell barrier realization gas exchange function. Regeneration include participation progenitor various niche involving several signaling pathways proteins. While alveoli are damaged, type II (AT2) proliferate differentiate into I (AT1) to repair damaged layer. Alveolar surrounded cells, fibroblasts, endothelial immune which affect proliferation differentiation AT2 through paracrine during regeneration. Besides, airway also contribute process epithelium. In this review, we mainly discuss transcription factors.

Language: Английский

Citations

15
Lung regeneration: diverse cell types and the therapeutic potential DOI Creative Commons
Yutian Chen, Zhen Li, Gaili Ji

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(2)

Published: Feb. 1, 2024

Abstract Lung tissue has a certain regenerative ability and triggers repair procedures after injury. Under controllable conditions, lung can restore normal structure function. Disruptions in this process lead to respiratory system failure even death, causing substantial medical burden. The main types of diseases are chronic obstructive pulmonary disease (COPD), idiopathic fibrosis (IPF), acute distress syndrome (ARDS). Multiple cells, such as epithelial endothelial fibroblasts, immune involved regulating the Although mechanism that regulates not been fully elucidated, clinical trials targeting different cells signaling pathways have achieved some therapeutic effects diseases. In review, we provide an overview cell type regeneration repair, research models, summarize molecular mechanisms regulation fibrosis. Moreover, discuss current stem therapy pharmacological strategies for COPD, IPF, ARDS treatment. This review provides reference further on cellular regeneration, drug development, trials.

Language: Английский

Citations

11