Changes in plasma endocannabinoids concentrations correlate with 18F-FDG PET/MR uptake in brown adipocytes in humans DOI Creative Commons
Katarzyna Maliszewska, Katarzyna Miniewska, Adrian Godlewski

et al.

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: July 26, 2023

Introduction: Recent data suggest a possible role of endocannabinoids in the regulation brown adipose tissue (BAT) activity. Those findings indicate potential treatment options for obesity. The aim this study was to evaluate relationship between plasma concentrations and presence BAT humans. Methods: group consisted 25 subjects divided into two groups: positive BAT(+), (n = 17, median age years) negative BAT(-), 8, 28 years). estimated using 18F-FDG PET/MR after 2 h cold exposure. level assessed at baseline, 60 min 120 Results: In both groups, BAT(+) during cooling, we observed decrease same endocannabinoids: arachidonoylethanolamide (AEA), eicosapentaenoyl ethanolamide (EPEA) oleoyl (OEA) with much more profound decline subjects. Statistically significant fall PEA (palmitoylethanolamide) SEA (stearoylethanolamide) (FC 0.7, p 0.007 FC 0.8, 0.03, respectively) 0.81, 0.004, 0.9, 0.01, cooling only individuals BAT. Conclusion: We noticed increased uptake Identification new molecules related activity may create target obesity treatment.

Language: Английский

Changes in plasma endocannabinoids concentrations correlate with 18F-FDG PET/MR uptake in brown adipocytes in humans DOI Creative Commons
Katarzyna Maliszewska, Katarzyna Miniewska, Adrian Godlewski

et al.

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: July 26, 2023

Introduction: Recent data suggest a possible role of endocannabinoids in the regulation brown adipose tissue (BAT) activity. Those findings indicate potential treatment options for obesity. The aim this study was to evaluate relationship between plasma concentrations and presence BAT humans. Methods: group consisted 25 subjects divided into two groups: positive BAT(+), (n = 17, median age years) negative BAT(-), 8, 28 years). estimated using 18F-FDG PET/MR after 2 h cold exposure. level assessed at baseline, 60 min 120 Results: In both groups, BAT(+) during cooling, we observed decrease same endocannabinoids: arachidonoylethanolamide (AEA), eicosapentaenoyl ethanolamide (EPEA) oleoyl (OEA) with much more profound decline subjects. Statistically significant fall PEA (palmitoylethanolamide) SEA (stearoylethanolamide) (FC 0.7, p 0.007 FC 0.8, 0.03, respectively) 0.81, 0.004, 0.9, 0.01, cooling only individuals BAT. Conclusion: We noticed increased uptake Identification new molecules related activity may create target obesity treatment.

Language: Английский

Citations

0