Synergistic therapeutic strategies and engineered nanoparticles for anti-vascular endothelial growth factor therapy in cancer

Life Sciences, Journal Year: 2024, Volume and Issue: 341, P. 122499 - 122499

Published: Feb. 10, 2024

Language: Английский

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Functional Relevance of Extracellular Vesicle-Derived Long Non-Coding and Circular RNAs in Cancer Angiogenesis

Non-Coding RNA, Journal Year: 2024, Volume and Issue: 10(1), P. 12 - 12

Published: Feb. 6, 2024

Extracellular vesicles (EVs) are defined as subcellular structures limited by a bilayer lipid membrane that function important intercellular communication transporting active biomolecules, such proteins, amino acids, metabolites, and nucleic including long non-coding RNAs (lncRNAs). These cargos can effectively be delivered to target cells induce highly variable response. LncRNAs functional composed of at least 200 nucleotides do not code for proteins. Nowadays, lncRNAs circRNAs known play crucial roles in many biological processes, plethora diseases cancer. Growing evidence shows an presence lnc- EVs, generating downstream responses ultimately affect cancer progression mechanisms, angiogenesis. Moreover, studies have revealed some tumor promote angiogenesis secreting which endothelial take up new vessel formation. In this review, we aim summarize the bioactive EVs with cargo their effect on Also, discuss future clinical strategies treatment based current knowledge circ- lncRNA-EVs.

Language: Английский

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Polysaccharides from Platycodon grandiflorum: A review of their extraction, structures, modifications, and bioactivities

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 271, P. 132617 - 132617

Published: May 23, 2024

Language: Английский

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Anti-angiogenic effects of cationic zinc (II) phthalocyanine derivatives through photodynamic therapy

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 20, 2025

In this study, the in vitro photodynamic therapy (PDT) activity of two zinc phthalocyanines (ZnPc1 and ZnPc2) was systematically examined human umbilical vein endothelial cells, focusing on PDT-induced cytotoxicity, reactive oxygen species (ROS) generation, inhibition angiogenic processes. Both ZnPcs demonstrated minimal cytotoxicity absence light, confirming their safety as photosensitizers. ZnPc-PDT led to significant cell death via apoptosis. ZnPc1 exhibited enhanced ROS particularly at elevated concentrations. Furthermore, ZnPc1-mediated PDT showed more pronounced migration, invasion, capillary-like tube formation than ZnPc2. Wound-healing assays revealed a substantial delay (HUVEC) migration following ZnPc1-PDT, which also displayed VEGF-induced directional invasion. Endothelial effectively disrupted by even lower concentrations, compared Collectively, these findings highlight superior cytotoxic anti-angiogenic properties with ZnPc2, highlighting its potential highly effective photosensitizer for therapy. The ability simultaneously target tumor cells disrupt angiogenesis establishes it potent candidate integrated cancer therapies that combine both antitumor antiangiogenic strategies, offering approach combat progression.

Language: Английский

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Quinoline and quinolone carboxamides: A review of anticancer activity with detailed structure–activity relationship analysis

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

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