Osteoporosis and dermatoporosis: a review on the role of vitamin D

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 24, 2023

Osteoporosis (OP) and Dermatoporosis (DP) are expressions of the aging process at skin bone levels, respectively. Both conditions associated with increased morbidity for elderly people, this requires necessary interventions. They share many common risk factors; among these, vitamin D (VD) deficiency appears to have a role. VD is involved in either disease mechanisms, which immunomodulation. has been linked OP because it inhibits body's capacity absorb calcium maintain optimal health. Available evidence suggests that proper vitaminosis also be vital preventing age-related issues. DP often seen individuals, particularly those long-term sun exposure history chronic damage. can DP, since its involvement collagen production, epidermal barrier function, inflammation regulation, wound healing, protection. Aim review summarize most updated existing on role development fragility syndromes such as possible benefits supplementation simple harmful weapon against aging.

Language: Английский

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Fibroblast heterogeneity: Keystone of tissue homeostasis and pathology in inflammation and ageing

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 28, 2023

Fibroblasts, derived from the embryonic mesenchyme, are a diverse array of cells with roles in development, homeostasis, repair, and disease across tissues. In doing so, fibroblasts maintain micro-environmental homeostasis create tissue niches by producing complex extracellular matrix (ECM) including various structural proteins. Although long considered phenotypically homogenous functionally identical, emergence novel technologies such as single cell transcriptomics has allowed identification different phenotypic cellular states to be attributed fibroblasts, highlighting their role regulation inflammation. Therefore, now recognised central actors many diseases, increasing need discover new therapies targeting those cells. Herein, we review heterogeneity functionality these health disease.

Language: Английский

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The effect of tomato and lycopene on clinical characteristics and molecular markers of UV-induced skin deterioration: A systematic review and meta-analysis of intervention trials

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(18), P. 6198 - 6217

Published: Jan. 6, 2023

Lycopene as a natural antioxidant that have been studied for ultraviolet radiation (UVR) photo protection and is one of the most effective carotenoids to scavenge reactive oxygen species (ROS). This review aims summarize protective effect tomato lycopene on skin damage photoaging in healthy subjects by reviewing existing population intervention experiments. A total five electronic databases including PubMed, Scopus, EBSCO, Web Science Cochrane Library were searched from inceptions January 2021 without any restriction. Out 19336 publications identified, 21 fulfilled inclusion criteria meta-analysis. Overall, interventions supplementing associated with significant reductions Δa*, MMP-1, ICAM-1 pigmentation; while supplementation increase MED, thickness density. Based results this systematic meta-analysis, could reduce erythema formation improve appearance pigmentation skin, thereby preventing light-induced photodamage photoaging. Lycopene-rich products be used endogenous sun may potential nutraceutical protection.

Language: Английский

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Clinically Actionable Topical Strategies for Addressing the Hallmarks of Skin Aging: A Primer for Aesthetic Medicine Practitioners

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 19, 2024

In this narrative review, we sought to provide a comprehensive overview of the mechanisms underlying cutaneous senescence, framed by twelve traditional hallmarks aging. These include genomic instability, telomere attrition, epigenetic alterations, loss proteostasis, impaired macroautophagy, deregulated nutrient sensing, mitochondrial dysfunction, cellular stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. We also examined how topical interventions targeting these can be integrated with conventional aesthetic medicine techniques enhance skin rejuvenation. The potential combining targeted therapies against aging minimally invasive procedures represents significant advancement in medicine, offering personalized effective strategies combat reviewed evidence paves way for future advancements underscores transformative integrating scientifically validated into practices.

Language: Английский

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Bioinorganic metal nanoparticles and their potential applications as antimicrobial, antioxidant and catalytic agents: a review

Reviews in Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: April 8, 2024

Abstract This review article covers the biogenic synthesis of metal nanoparticles (MNPs) having definite shape and size while using extract obtained from different biological sources such as bacteria, fungi, algae plants. These materials are composed chloroplast, thylakoid, types enzymes extracted sources, phytochemicals phenols, flavonoids, citric acid functional groups sulfate, carboxyl, amino, amide hydroxyl groups. act efficient reductants to convert ions into atoms alternatively combine form MNPs long hydrocarbon chains present in these bio-macromolecules cage stabilize them for prolong time. Effect nature source extract, reaction conditions amount, salt amount solvent used during preparation process have been critically discussed here detail. Use synthesized bioinorganic NPs various areas including their effectiveness fighting against viruses, cancer, inflammation, potential role catalytic reduction environmental harmful substances friendly products has also described a clear concise manner along with future consideration.

Language: Английский

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