Russian Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
93(11), P. RCR5150 - RCR5150
Published: Oct. 30, 2024
Diabetes
and
its
complications
derived
are
among
serious
global
health
concerns
that
critically
deteriorate
the
quality
of
life
patients
and,
in
some
cases,
result
lethal
outcome.
Herein,
general
information
on
pathogenesis,
factors
aggravating
course
disease
drugs
used
for
treatment
two
types
diabetes
briefly
discussed.
The
aim
review
is
to
introduce
supramolecular
strategies
currently
being
developed
mellitus
present
a
very
effective
alternative
chemical
synthesis,
allowing
fabrication
nanocontainers
with
switchable
characteristics
meet
criteria
green
chemistry.
Particular
attention
paid
organic
(amphiphilic
polymeric)
formulations,
including
those
natural
origin,
due
their
biocompatibility,
low
toxicity,
bioavailability.
advantages
limitations
different
nanosystems
discussed,
emphasis
adaptivity
noninvasive
administration
routes.<br>The
bibliography
includes
378
references.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(15), P. 12312 - 12312
Published: Aug. 1, 2023
A
synthesis
procedure
and
aggregation
properties
of
a
new
homologous
series
dicationic
gemini
surfactants
with
dodecane
spacer
two
carbamate
fragments
(N,N'-dialkyl-N,N'-bis(2-(ethylcarbamoyloxy)ethyl)-N,N'-dimethyldodecan-1,6-diammonium
dibromide,
n-12-n(Et),
where
n
=
10,
12,
14)
were
comprehensively
described.
The
critical
micelle
concentrations
obtained
using
tensiometry,
conductometry,
spectrophotometry,
fluorimetry.
thermodynamic
parameters
adsorption
micellization,
i.e.,
maximum
surface
excess
(Гmax),
the
area
per
surfactant
molecule
(Amin),
degree
counterion
binding
(β),
Gibbs
free
energy
micellization
(∆Gmic),
calculated.
Functional
activity
surfactants,
including
solubilizing
capacity
toward
Orange
OT
indomethacin,
incorporation
into
lipid
bilayer,
minimum
inhibitory
concentration,
bactericidal
fungicidal
concentrations,
was
determined.
Synthesized
further
used
for
modification
liposomes
dual-loaded
α-tocopherol
donepezil
hydrochloride
intranasal
treatment
Alzheimer's
disease.
have
high
stability
(more
than
5
months),
significant
positive
charge
(approximately
+
40
mV),
encapsulation
efficiency
rhodamine
B,
α-tocopherol,
hydrochloride.
Korsmeyer-Peppas,
Higuchi,
first-order
kinetic
models
to
process
in
vitro
release
curves
Intranasal
administration
loaded
21
days
prevented
memory
impairment
decreased
number
Aβ
plaques
by
37.6%,
40.5%,
72.6%
entorhinal
cortex,
DG,
CA1
areas
hippocampus
brain
transgenic
mice
disease
model
(APP/PS1)
compared
untreated
animals.
Russian Journal of General Chemistry,
Journal Year:
2023,
Volume and Issue:
93(7), P. 1867 - 1899
Published: July 1, 2023
Abstract
The
review
focuses
on
the
lipid
based
nanocarriers,
with
special
attention
paid
to
natural
bioactive
payloads.
First,
micelles
and
microemulsions
are
considered
as
very
attractive
colloidal
nanocontainers
that
allow
for
marked
improving
solubility
of
hydrophobic
bioactives.
Further,
liposomal
vehicles
reviewed,
both
advantages
limitations
discussed.
Literature
assay
covers
up-to-date
information
about
last
three
five
years,
although
brief
background
is
given
pioneer
works
addressing
liposomes
their
evolution
from
bench
bedside.
Final
part
devoted
modern
modifications
vesicular
nanocarriers
which
can
be
adapted
specific
administration
way
due
improved
targeting
properties,
permeability,
mucoadhesiveness
possibility
cross
biological
barriers.
Therein,
such
kinds
transfersomes,
niosomes,
ethosomes,
chitosomes
evaluated;
separate
sections
focus
formulations,
i.e.,
phytosomes
invasomes.
Current Drug Metabolism,
Journal Year:
2024,
Volume and Issue:
25(4), P. 248 - 265
Published: May 1, 2024
:
Modern
nanostructures
must
fulfill
a
wide
range
of
functions
to
be
valuable,
leading
the
combi-nation
various
nano-objects
into
hierarchical
assemblies.
Hybrid
Nanoparticles
(HNPs),
comprised
mul-tiple
types
nanoparticles,
are
emerging
as
nanoscale
structures
with
versatile
applications.
HNPs
offer
en-hanced
medical
benefits
compared
basic
combinations
distinct
components.
They
address
limitations
traditional
nanoparticle
delivery
systems,
such
poor
water
solubility,
nonspecific
targeting,
and
subopti-mal
therapeutic
outcomes.
also
facilitate
transition
from
anatomical
molecular
imaging
in
lung
cancer
diagnosis,
ensuring
precision.
In
clinical
settings,
selection
nanoplatforms
superior
repro-ducibility,
cost-effectiveness,
easy
preparation,
advanced
functional
structural
characteristics
is
para-mount.
This
study
aims
toextensively
examine
hybrid
focusing
on
their
classification,
drug
de-livery
mechanisms,
properties
inorganic
advancements
technol-ogy,
biomedical
applications,
particularly
emphasizing
utilization
smart
nanoparticles.
PHNPs
enable
numerous
anticancer,
anti-leishmanial,
antifungal
drugs,
enhancing
cellular
absorption,
bioavailability,
targeted
while
reducing
toxic
side
effects.
Molecular Therapy — Nucleic Acids,
Journal Year:
2024,
Volume and Issue:
35(3), P. 102313 - 102313
Published: Aug. 19, 2024
The
use
of
mRNA
and
ribonucleoproteins
(RNPs)
as
therapeutic
agents
is
a
promising
strategy
for
treating
diseases
such
cancer
infectious
diseases.
This
review
provides
recent
advancements
challenges
in
mRNA-
RNP-based
therapies,
focusing
on
delivery
systems
lipid
nanoparticles
(LNPs),
which
ensure
efficient
to
target
cells.
Strategies
microfluidic
devices
are
employed
prepare
LNPs
loaded
with
RNPs,
demonstrating
effective
genome
editing
protein
expression
vitro
vivo.
These
applications
extend
treatment
disease
management,
results
therapy
using
encapsulating
Cas9
single-guide
RNA.
In
addition,
tissue-specific
targeting
strategies
offer
potential
improved
outcomes
reduced
off-target
effects.
Despite
progress,
optimizing
efficiency
remain.
Future
research
should
enhance
efficiency,
explore
targeting,
investigate
combination
advance
clinical
translation.
conclusion,
therapies
avenue
various
have
the
revolutionize
medicine,
providing
new
hope
patients
worldwide.
Russian Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
93(11), P. RCR5150 - RCR5150
Published: Oct. 30, 2024
Diabetes
and
its
complications
derived
are
among
serious
global
health
concerns
that
critically
deteriorate
the
quality
of
life
patients
and,
in
some
cases,
result
lethal
outcome.
Herein,
general
information
on
pathogenesis,
factors
aggravating
course
disease
drugs
used
for
treatment
two
types
diabetes
briefly
discussed.
The
aim
review
is
to
introduce
supramolecular
strategies
currently
being
developed
mellitus
present
a
very
effective
alternative
chemical
synthesis,
allowing
fabrication
nanocontainers
with
switchable
characteristics
meet
criteria
green
chemistry.
Particular
attention
paid
organic
(amphiphilic
polymeric)
formulations,
including
those
natural
origin,
due
their
biocompatibility,
low
toxicity,
bioavailability.
advantages
limitations
different
nanosystems
discussed,
emphasis
adaptivity
noninvasive
administration
routes.<br>The
bibliography
includes
378
references.
