International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(24), P. 15645 - 15645
Published: Dec. 9, 2022
Ischemic
stroke
(IS)
related
to
atherosclerosis
of
large
arteries
is
one
the
leading
causes
mortality
and
disability
in
developed
countries.
Atherosclerotic
internal
carotid
artery
stenosis
(ICAS)
contributes
20%
all
cerebral
ischemia
cases.
Nowadays,
prevention
treatment
measures
aim
at
controlling
risk
factors,
or
interventional
(surgical
endovascular)
management
mature
occlusive
lesions.
There
a
definite
lack
established
circulating
biomarkers
which,
once
modulated,
could
prevent
development
atherosclerosis,
consequently
carotid-artery-related
IS.
Recent
studies
emphasize
that
microRNA
(miRNA)
are
emerging
particles
potentially
play
pivotal
role
this
approach.
some
research
on
association
between
expression
small
non-coding
microRNAs
with
plaque
vulnerability.
However,
data
remain
inconsistent.
In
addition,
major
atherosclerotic
were
conducted
cell
culture
animal
models;
very
few
humans,
whereas
accumulating
evidence
demonstrates
it
cannot
be
automatically
extrapolated
processes
humans.
Therefore,
paper
aims
review
current
knowledge
how
miRNA
participate
process
formation
rupture,
as
well
occurrence.
We
discuss
potential
target
used
prognostic
therapeutic
tool.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(26)
Published: May 5, 2024
Abstract
Atherosclerosis
is
the
primary
cause
of
cardiovascular
disease,
resulting
in
mortality,
elevated
healthcare
costs,
diminished
productivity,
and
reduced
quality
life
for
individuals
their
communities.
This
exacerbated
by
limited
understanding
its
underlying
causes
limitations
current
therapeutic
interventions,
highlighting
need
sophisticated
models
atherosclerosis.
review
critically
evaluates
computational
biological
atherosclerosis,
focusing
on
study
hemodynamics
atherosclerotic
coronary
arteries.
Computational
account
geometrical
complexities
blood
vessels
stenoses,
but
they
fail
to
capture
complex
processes
involved
Different
vitro
vivo
can
aspects
complexity
healthy
stenosed
vessels,
rarely
mimic
human
anatomy
physiological
hemodynamics,
require
significantly
more
time,
cost,
resources.
Therefore,
emerging
strategies
are
examined
that
integrate
models,
potential
advances
imaging,
biofabrication,
machine
learning
explored
developing
effective
Frontiers in Cardiovascular Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: May 13, 2024
Cardiovascular
diseases
(CVD)
are
the
leading
cause
of
death
worldwide,
despite
advances
in
understanding
cardiovascular
health.
Significant
barriers
still
exist
effectively
preventing
and
managing
these
diseases.
Vascular
smooth
muscle
cells
(VSMCs)
crucial
for
maintaining
vascular
integrity
can
switch
between
contractile
synthetic
functions
response
to
stimuli
such
as
hypoxia
inflammation.
These
transformations
play
a
pivotal
role
progression
diseases,
facilitating
modifications
disease
advancement.
This
article
synthesizes
current
mechanisms
signaling
pathways
regulating
VSMC
phenotypic
transitions,
highlighting
their
potential
therapeutic
targets
interventions.
Frontiers in Cell and Developmental Biology,
Journal Year:
2021,
Volume and Issue:
9
Published: Nov. 10, 2021
Cardiovascular
remodeling
occurs
in
cardiomyocytes,
collagen
meshes,
and
vascular
beds
the
progress
of
cardiac
insufficiency
caused
by
a
variety
diseases
such
as
chronic
ischemic
heart
disease,
overload
myocarditis,
myocardial
infarction.
The
morphological
changes
that
occur
result
are
critical
pathological
basis
for
occurrence
development
serious
also
determine
morbidity
mortality.
Therefore,
inhibition
is
an
important
approach
to
prevent
treat
failure
other
related
diseases.
endoplasmic
reticulum
(ER)
mitochondria
tightly
linked
ER-mitochondria
contacts
(ERMCs).
ERMCs
play
vital
role
different
signaling
pathways
provide
satisfactory
structural
platform
ER
interact
maintain
normal
function
cells,
mainly
involving
various
cellular
life
processes
lipid
metabolism,
calcium
homeostasis,
mitochondrial
function,
stress,
autophagy.
Studies
have
shown
abnormal
may
promote
participate
formation
cardiovascular
remodeling-associated
This
review
focuses
on
structure
ERMCs,
potential
mechanism
involved
remodeling,
indicating
be
target
new
therapeutic
strategies
against
remodeling-induced
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(24), P. 15645 - 15645
Published: Dec. 9, 2022
Ischemic
stroke
(IS)
related
to
atherosclerosis
of
large
arteries
is
one
the
leading
causes
mortality
and
disability
in
developed
countries.
Atherosclerotic
internal
carotid
artery
stenosis
(ICAS)
contributes
20%
all
cerebral
ischemia
cases.
Nowadays,
prevention
treatment
measures
aim
at
controlling
risk
factors,
or
interventional
(surgical
endovascular)
management
mature
occlusive
lesions.
There
a
definite
lack
established
circulating
biomarkers
which,
once
modulated,
could
prevent
development
atherosclerosis,
consequently
carotid-artery-related
IS.
Recent
studies
emphasize
that
microRNA
(miRNA)
are
emerging
particles
potentially
play
pivotal
role
this
approach.
some
research
on
association
between
expression
small
non-coding
microRNAs
with
plaque
vulnerability.
However,
data
remain
inconsistent.
In
addition,
major
atherosclerotic
were
conducted
cell
culture
animal
models;
very
few
humans,
whereas
accumulating
evidence
demonstrates
it
cannot
be
automatically
extrapolated
processes
humans.
Therefore,
paper
aims
review
current
knowledge
how
miRNA
participate
process
formation
rupture,
as
well
occurrence.
We
discuss
potential
target
used
prognostic
therapeutic
tool.
