Cardiotoxicity of Iron and Zinc and Their Association with the Mitochondrial Unfolded Protein Response in Humans

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9648 - 9648

Published: Sept. 6, 2024

This study was designed to examine the association between myocardial concentrations of trace elements Cu, Fe, Mn, Mo, and Zn expression mitochondrial unfolded protein response (UPRmt) age patients who received heart transplantation or a left-ventricular assist device (ageHTx/LVAD). Inductively coupled plasma mass spectrometry used determine concentration in myocardium control subjects undergoing (LVAD) implantation. We ELISA quantify UPRmt proteins 4-Hydroxynonenal (4-HNE), which served as marker oxidative-stress-induced lipid peroxidation. Concentrations were similar failure (HF) myocardium, while Fe showed significant decrease HF group compared control. A higher cumulative associated with reduced ageHTx/LVAD, not observed for other combinations their individual effects. The positive correlations several proteins, had negative correlation effector protease YME1L. None correlated 4-HNE myocardium. Mn significantly dilated cardiomyopathy than ischemic cardiomyopathy. younger at LVAD, potentially suggesting an acceleration HF. YME1L suggest that these exerted actions on human by interacting UPRmt. An altered generation oxidative stress underlying mechanism changes.

Language: Английский

---

Cuproptosis: A Copper‐Mediated Programmed Cell Death

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

It has been found that various heavy metals can initiate different types of regulated cell deaths. Among these metals, copper, an essential trace micronutrient plays a major role in lot physiological processes, also death. act as constituent metalloenzymes, and mediator for signaling pathways to regulate proliferation metastasis tumor. is integral part some metal-based anticancer drugs. Recent studies have revealed excessive intracellular copper accumulation leads the aggregation mitochondrial lipoylated proteins, causing proteotoxic stress ultimately resulting This newly discovered copper-induced death termed cuproptosis. In last few years, research done understand mechanism copper-mediated death, attempts made identify relationship between cuproptosis development cancer. this review, we provided comprehensive overview on significance its regulation inside body, possible cuproptosis, how be employed therapeutic tool cancer ablation.

Language: Английский

---

A Study of Dopaminergic Pathway in Neurologic Wilson Disease with Movement Disorder

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 60(6), P. 3496 - 3506

Published: March 7, 2023

Language: Английский

---

Nondestructive Evaluation of Metal Bioaccumulation and Biochemical Biomarkers in Blood of Broad‐Snouted Caiman (Caiman latirostris) from Northeastern Brasil

Environmental Toxicology and Chemistry, Journal Year: 2024, Volume and Issue: 43(4), P. 878 - 895

Published: Feb. 27, 2024

Abstract Studies on the bioaccumulation and toxicity of contaminants in Crocodylians are scarce. We evaluated alterations concentrations nondestructive biomarkers butyrylcholinesterase (BChE), glutathione‐S‐transferase (GST), superoxide dismutase (SOD), reduced glutathione (GSH), together with metals iron (Fe), copper (Cu), zinc (Zn), manganese (Mn), chronium (Cr), aluminium (Al), lead (Pb) Caiman latirostris captured Tapacurá Reservoir (TR; São Lourenço da Mata, Pernambuco, Brasil), urbanized areas Pernambuco State (UA; Brasil) from AME Brasil caiman farm (AF; Marechal Deodoro, Alagoas, Brasil); latter was used as a potential reference low levels contamination. For metal analysis, 500 µL blood digested 65% HNO 3 30% H 2 O . The samples were analyzed by inductively coupled plasma–optical emission spectrometry. analysis biomarkers, an aliquot centrifuged to obtain plasma which biochemical assays performed. Blood animals AF lower compared TR UA, confirming that could be references Iron, Cu, Mn, Al, Pb exceeded toxic for other vertebrates UA. Butyrylcholinesterase activity showed significant reduction adults UA AF. An increase GST GSH, relation AF, verified. Superoxide Cu Mn negatively correlated SOD activity. Animals greater animals, changes seen, these chemical biological parameters C. biomonitoring pollution. Environ Toxicol Chem 2024;43:878–895. © 2024 SETAC

Language: Английский

---

Unraveling the link between heavy metals, perfluoroalkyl substances and depression: Insights from epidemiological and bioinformatics strategies

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116482 - 116482

Published: May 20, 2024

Heavy metals and per- polyfluoroalkyl substances (PFASs) have become particularly important when studying the development of depression, a common illness that severely restricts psychosocial functioning diminishes quality life. Therefore, potential joint effects heavy metal PFAS exposure on as well underlying mechanisms involved, were investigated by using integrated epidemiological bioinformatic approaches in present study. A thorough analysis 7301 samples from National Health Nutrition Examination Survey (NHANES) cycles occurred between 2005 2018 was performed. Single-exposure studies shown cadmium is positively associated with whereas perfluorooctanesulfonic acid (PFOS) perfluorodecanoic (PFDE) are negatively depression. Furthermore, Bayesian kernel machine regression (BKMR) quantile g-computation (QGcomp) models employed to investigate collective impact mixed Cadmium emerged principal contributor Moreover, addition mixture had an antagonistic effect PFOS having most prominent influence. Analysis co-exposure confirmed presence effect. The inflection points determined be −1.11 2.27, respectively. Additionally, opposite two crucial pathways, namely, rap1 calcium signaling which involve core genes related depression such ADORA2A, FGF2, FGFR1. These findings significant implications for future provide new strategies exploring effects.

Language: Английский

---