Clinical Epigenetics,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Oct. 16, 2024
The
role
of
epigenetics
in
cardiovascular
diseases
has
paved
the
way
for
innovative
therapeutic
approaches.
Investigating
epigenetic
changes
using
cell-free
DNA
(cfDNA)
holds
substantial
promise
beyond
mere
diagnostics,
especially
heart-related
conditions
like
acute
myocardial
infarction
(AMI),
where
obtaining
tissue
samples
is
a
challenge.
This
study
explores
methylation
patterns
cfDNA
AMI
patients
and
compares
them
with
genomic
(gDNA)
from
same
individuals,
aiming
to
evaluate
effectiveness
as
valuable
resource
studying
diseases.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4058 - 4058
Published: April 25, 2025
Pituitary
neuroendocrine
tumors
(PitNETs)
are
slow-growing
neoplasms
with
various
clinical
presentations,
often
leading
to
diagnostic
challenges.
While
neuroimaging
assessment
and
histopathological
evaluation
remain
the
gold
standard
for
diagnosis,
emerging
research
highlights
potential
of
liquid
biopsy,
mainly
through
analysis
circulating
non-coding
RNAs
(ncRNAs),
as
a
promising
prognostic
tool.
Recent
studies
have
demonstrated
distinct
expression
profiles
in
different
types
subtypes
tumors,
implications
assessing
tumor
aggressiveness
predicting
treatment
response.
The
current
article
summarizes
data
about
biofluid
markers
implicated
PitNET
development,
DNA
(ctDNA),
cell-free
(cfRNA),
cells
(CTCs),
exosomes.
Many
on
genetic
molecular
tissue
samples
provide
exciting
information
biology,
but
date,
specific
biopsy
biomarkers
still
few.
Over
past
years,
certain
understanding
mechanisms
involved
pituitary
tumorigenesis
has
been
gained,
including
landscape
genomic
alterations,
changes
epigenetic
profile,
crucial
molecules
signaling
pathways,
RNA
critical
roles
malignant
transformation.
Genetic
characterization
PitNETs
could
help
distinguish
between
functional
non-functional
PitNETs,
invasive
non-invasive
forms.
Further
required
identify
validate
innovative
or
therapeutic
targets
treating
PitNET.
Integrating
into
workflows
revolutionize
management
adenomas,
enabling
more
personalized
less
strategies.
Russian Journal of Cardiology,
Journal Year:
2025,
Volume and Issue:
30(6S), P. 6235 - 6235
Published: May 6, 2025
One
of
the
urgent
tasks
is
search
for
early
and
specific
markers
cardiovascular
diseases
(CVD)
in
order
to
stratify
cardiovascular
risk,
develop
methods
their
prevention,
diagnosis
treatment.
In
recent
decades,
considerable
attention
has
been
paid
plasma
cell-free
nucleic
acids
free:
circulating
DNA
(сfDNA)
non-coding
RNA,
particular
microRNA,
which
are
considered
as
promising
prognostic
diagnostic
biomarkers
many
pathological
conditions,
since
they
play
a
key
role
regulation
physiological
pathophysiological
processes.
This
review
covers
current
understanding
potential
cfDNA
microRNA
assessment
patients
biomarkers
diagnosis,
risk
stratification,
severity
monitoring
CVD,
with
focus
on
coronary
artery
disease,
heart
failure
cardiac
allograft
rejection,
where
this
area
research
promising.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1826 - 1826
Published: March 17, 2023
Head
and
neck
squamous
cell
carcinomas
(HNSCCs)
arising
from
different
anatomical
sites
present
with
incidences
characteristics,
which
requires
a
personalized
treatment
strategy.
Despite
the
extensive
research
that
has
conducted
on
this
malignancy,
HNSCC
still
poor
overall
survival
rate.
Many
attempts
have
been
made
to
improve
outcomes,
but
one
of
bottlenecks
is
thought
be
lack
an
effective
biomarker
high
sensitivity
specificity.
Extracellular
vesicles
(EVs)
are
secreted
by
various
cells
participate
in
great
number
intercellular
communications.
Based
liquid
biopsy,
EV
detection
several
biofluids,
such
as
blood,
saliva,
urine,
applied
identify
existence
progression
variety
cancers.
In
HNSCC,
tumor-derived
EVs
exhibit
many
functionalities
transporting
diverse
cargoes,
highlights
their
importance
tumor
screening,
determination
multidisciplinary
therapy,
prediction
prognosis,
evaluation
therapeutic
effects.
This
review
illustrates
classification
formation
subtypes,
cargoes
conveyed
these
vesicles,
respective
functions
cancer
biology,
discloses
potential
biomarkers
during
whole
process
diagnosis,
treatment,
follow-up.
Clinical Epigenetics,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Oct. 16, 2024
The
role
of
epigenetics
in
cardiovascular
diseases
has
paved
the
way
for
innovative
therapeutic
approaches.
Investigating
epigenetic
changes
using
cell-free
DNA
(cfDNA)
holds
substantial
promise
beyond
mere
diagnostics,
especially
heart-related
conditions
like
acute
myocardial
infarction
(AMI),
where
obtaining
tissue
samples
is
a
challenge.
This
study
explores
methylation
patterns
cfDNA
AMI
patients
and
compares
them
with
genomic
(gDNA)
from
same
individuals,
aiming
to
evaluate
effectiveness
as
valuable
resource
studying
diseases.
