Current Research in Toxicology, Journal Year: 2024, Volume and Issue: 6, P. 100169 - 100169

Published: Jan. 1, 2024

Neonicotinoids (NEOs) are widely used insecticides that ubiquitous in agricultural use. Since NEOs found natural waters as well tap water and human urine regions where used, pose a potential hazard to non-target organisms such animals humans. Some of the commonly detected imidacloprid (IMD), thiamethoxam (TMX), its metabolite clothianidin (CLO). Although previously published scientific information, including an assessment environmental risks, particularly for bees, had resulted ban on outdoor use these three EU – their is now only permitted closed greenhouses continue be agriculture many other parts world. Therefore, detailed study comparison effects embryonic development needed further define risk profiles. Embryos South African clawed frog Xenopus laevis, well-established aquatic model, were exposed different concentrations IMD, TMX, or CLO (0.1–100 mg/L) compare possible single contaminant bodies early embryogenesis. The results included reduced body length, smaller orbital space, impaired cranial cartilage nerves, altered heart structure function. At molecular level, NEO exposure partially expression tissue-specific factors, which involved eye, placode, development. Our suggest studied negatively affect organism X. laevis. pesticides, especially NEOs, pollute environment worldwide, it suggested they strictly controlled monitored areas used. In addition, question arises whether pesticide metabolites also need investigated so can taken into account when registering ingredients.

Language: Английский