Dehydrocostus lactone inhibits Candida albicans growth and biofilm formation DOI Creative Commons
Jingxiao Zhang,

Jian Sun,

Yu Zhang

et al.

AMB Express, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 4, 2023

Abstract Candida albicans infections are threatening public health but there only several antifungal drugs available. This study was to assess the effects of dehydrocostus lactone (DL) on growth and biofilms Microdilution assays revealed that DL inhibits a panel standard species, including C. , as well 9 clinical isolates. The morphological transition in RPMI-1640 medium adhesion polystyrene surfaces can also be decreased by treatment, evidenced microscopic, metabolic activity colony forming unit (CFU) counting assays. XTT assay microscopy inspection demonstrated inhibit . Confocal following propidium iodide (PI) staining DCFH-DA after treatment increase membrane permeability intracellular reactive oxygen species (ROS) production. N -acetyl-cysteine could mitigate inhibitory growth, biofilm formation, further confirming ROS production induced contributes its antibiofilm effects. showed against mechanisms may involve damage overproduction. shows potential fight infections.

Language: Английский

4-OI ameliorates bleomycin-induced pulmonary fibrosis by activating Nrf2 and suppressing macrophage-mediated epithelial-mesenchymal transition DOI
Yaxian Wu, Yaru Zhang, Fengjuan Jiang

et al.

Inflammation Research, Journal Year: 2023, Volume and Issue: 72(6), P. 1133 - 1145

Published: May 11, 2023

Language: Английский

Citations

13
The role and mechanisms of mesenchymal stem cells regulating macrophage plasticity in spinal cord injury DOI Open Access

Sheng-Ping Fu,

Xiang-Chong Wu,

Ruilin Yang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115632 - 115632

Published: Oct. 6, 2023

Spinal Cord Injury (SCI) is a devastating neurological disorder comprising primary mechanical injury and secondary inflammatory response-mediated for which an effective treatment still unavailable. It well known that responses are significant cause of difficulties in recovery. An immune imbalance between M1/M2 macrophages at the sites involved developing progressing response. Recently, Mesenchymal Stem Cells (MSCs) have shown therapeutic potential tissue engineering regenerative medicine due to their multidirectional differentiation immunomodulatory properties. Accumulating evidence shows MSCs can regulate balance macrophage polarization, suppress downstream responses, facilitate repair regeneration, improve prognosis SCI. This article briefly overviews impact on SCI repair. discusses mechanisms by plasticity, including paracrine action, release exosomes apoptotic bodies, metabolic reprogramming. Additionally, summarizes relevant signaling pathways polarization.

Language: Английский

Citations

12
Preclinical evidence using synthetic compounds and natural products indicates that AMPK represents a potential pharmacological target for the therapy of pulmonary diseases DOI
Chao Yang, Limor Rubin, Xiyong Yu

et al.

Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: 44(3), P. 1326 - 1369

Published: Jan. 16, 2024

Abstract Adenosine 5′‐monophosphate (AMP)‐activated protein kinase (AMPK) is a highly conserved eukaryotic enzyme discovered as key regulator of cellular energy homeostasis, with anti‐inflammation, antioxidative stress, anticancer, and antifibrosis beneficial effects. AMPK dysregulated in human pulmonary diseases such acute lung injury, nonsmall cell cancer, fibrosis, chronic obstructive disease, asthma. This review provides an overview the role natural, synthetic, Chinese traditional medicines modulators diseases, highlights signaling pathway lung, emphasizing importance finding lead compounds drugs that can target modulate to treat diseases.

Language: Английский

Citations

4
Catechol compounds as dual-targeting agents for fish protection against Ichthyophthirius multifiliis infections DOI

Shenye Qu,

Yihang Liu,

Jietao Liu

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 151, P. 109717 - 109717

Published: June 22, 2024

Language: Английский

Citations

4
The Role of AMPK Signaling in Ulcerative Colitis DOI Creative Commons

Yuyi Yuan,

Fang Wang, Xingxing Liu

et al.

Drug Design Development and Therapy, Journal Year: 2023, Volume and Issue: Volume 17, P. 3855 - 3875

Published: Dec. 1, 2023

Abstract: Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease characterized by inflammation and ulcer formation of the intestinal mucosa. Due to its high recurrence rate, prolonged course, limited curative options, significant impact on patients' quality life, along with notable potential for malignant transformation, UC designated as refractory global health challenge World Health Organization (WHO). The elucidation pathogenesis therapeutic strategies requires further in-depth investigation. AMP-activated protein kinase (AMPK) serves central regulator cellular energy metabolic homeostasis. Emerging evidence indicates that interventions involving traditional Chinese medicine (TCM) components, well other pharmacological measures, exert beneficial effects mucosal epithelial barrier dysfunction in modulating AMPK signaling, thereby influencing biological processes such autophagy, apoptosis, responses, macrophage polarization, NLRP3 inflammasome-mediated pyroptosis. role importance. This manuscript provides comprehensive overview mechanisms through which involved UC, compilation agents capable activating signaling pathway within context UC. primary objective facilitate deeper comprehension pivotal among researchers clinical practitioners, advancing identification novel targets Keywords: ulcerative colitis, AMPK, colitis-associated processes, monomers

Language: Английский

Citations

11
Novel ligustilide derivatives target quorum sensing system LasR/LasB and relieve inflammatory response against Pseudomonas aeruginosa infection DOI
Jun Liu,

Qiu‐Xian Chen,

Wenfu Wu

et al.

European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 263, P. 115972 - 115972

Published: Nov. 20, 2023

Language: Английский

Citations

10
Natural Compounds Regulate Macrophage Polarization and Alleviate Inflammation Against ALI/ARDS DOI Creative Commons
Zhinan Yin, Ruolin Song, Tong Yu

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 192 - 192

Published: Jan. 29, 2025

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a pulmonary disease with high mortality associated inflammation. During the development of ALI/ARDS, macrophages usually polarize toward M1 pro-inflammatory macrophages, promoting inflammatory response in ALI/ARDS and aggravating tissue damage. Natural compounds anti-inflammatory activity have achieved excellent results treatment through different regulatory modes, including macrophage polarization. Of note, flavonoid, brevilin A, tetrahydropalmatine play an important role by modulating phenotypic polarization their cytokine expression innate immune cells lung. Flavonoids are kind naturally occurring polyphenol compound, which has antioxidant activities. Studies found that some flavonoids can alleviate inhibiting cytokines macrophages. Among them, 5-methoxyflavone, acacetin, grape seed proanthocyanidins, luteolin also regulate Therefore, in-depth exploration mechanism lay foundation for application alleviating inflammation-related injury. This review focuses on effects natural potential mechanisms ALI/ARDS.

Language: Английский

Citations

0
Identification of novel natural inhibitors of Mycobacterium tuberculosis DNA-directed RNA polymerase via extensive computational screening and MMGBSA DOI
Muhammad Bilal Azmi, Muhammad Waqas,

Shahid Durran

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127360 - 127360

Published: March 1, 2025

Language: Английский

Citations

0
The application of proteomics and metabolomics to reveal the molecular mechanism of Nutmeg-5 in ameliorating cardiac fibrosis following myocardial infarction DOI
Tingting Yan, Xiaoling Zhu, Xueni Zhang

et al.

Phytomedicine, Journal Year: 2022, Volume and Issue: 105, P. 154382 - 154382

Published: Aug. 3, 2022

Language: Английский

Citations

15
The potential role of Hippo pathway regulates cellular metabolism via signaling crosstalk in disease-induced macrophage polarization DOI Creative Commons

Yina An,

Shuyu Tan,

Jingjing Yang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 11, 2024

Macrophages polarized into distinct phenotypes play vital roles in inflammatory diseases by clearing pathogens, promoting tissue repair, and maintaining homeostasis. Metabolism serves as a fundamental driver regulating macrophage polarization, understanding the interplay between metabolism polarization is crucial for unraveling mechanisms underlying diseases. The intricate network of cellular signaling pathway plays pivotal role modulating metabolism, growing evidence indicates that Hippo emerges central player signaling. This review aims to explore impact on summarize cell pathways regulate Specifically, we highlight key regulator reveal its potential relationship with polarization.

Language: Английский

Citations

3