More than Addiction—The Nucleus Accumbens Contribution to Development of Mental Disorders and Neurodegenerative Diseases

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2618 - 2618

Published: Feb. 27, 2022

Stress and negative emotions evoked by social relationships working conditions, frequently accompanied the consumption of addictive substances, metabolic and/or genetic predispositions, negatively affect brain function. One affected structures is nucleus accumbens (NAc). Although its function commonly known to be associated with reward responses addiction, a growing body evidence also suggests role in some mental disorders, such as depression schizophrenia, well neurodegenerative diseases, Alzheimer's, Huntington's, Parkinson's. This may result from disintegration extensive connections based on numerous neurotransmitter systems, impairment neuroplasticity mechanisms NAc. The consequences NAc lesions are both morphological functional. They include changes NAc's volume, cell number, modifications neuronal dendritic tree spines, number synapses. Alterations synaptic plasticity efficiency transmission. Modification structure receptors affects signaling pathways, content neuromodulators (e.g., BDNF) transcription factors pCREB, DeltaFosB, NFκB), gene expression. Interestingly, often have different character intensity compared observed other parts basal ganglia, particular dorsal striatum. In this review, we highlight various pathological processes context structural functional damage, impaired areas cooperating within progression processes.

Language: Английский

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Plasticity of synapses and reward circuit function in the genesis and treatment of depression

Neuropsychopharmacology, Journal Year: 2022, Volume and Issue: 48(1), P. 90 - 103

Published: Sept. 3, 2022

Language: Английский

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Addictive drugs modify neurogenesis, synaptogenesis and synaptic plasticity to impair memory formation through neurotransmitter imbalances and signaling dysfunction

Neurochemistry International, Journal Year: 2023, Volume and Issue: 169, P. 105572 - 105572

Published: July 7, 2023

Language: Английский

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Shared Mechanisms of GABAergic and Opioidergic Transmission Regulate Corticolimbic Reward Systems and Cognitive Aspects of Motivational Behaviors

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(5), P. 815 - 815

Published: May 17, 2023

The functional interplay between the corticolimbic GABAergic and opioidergic systems plays a crucial role in regulating reward system cognitive aspects of motivational behaviors leading to development addictive disorders. This review provides summary shared mechanisms transmission, which modulate activity dopaminergic neurons located ventral tegmental area (VTA), central hub mechanisms. comprehensively covers neuroanatomical neurobiological inhibitory that express opioid receptors, act as modulators transmission. presence GABA receptors on same allows for modulation area, key brain. colocalization their immunochemical markers can provide comprehensive understanding clinicians researchers, revealing neuronal circuits contribute system. Moreover, this highlights importance transmission-induced neuroplasticity under receptors. It discusses interactive reinforcement learning, network oscillation, aversive behaviors, local feedback or feedforward inhibitions Understanding these may lead new therapeutic approaches addiction, reward-related disorders, drug-induced impairment.

Language: Английский

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Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

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Aberrant white matter structural connectivity of nucleus accumbens in patients with major depressive disorder: A probabilistic fibre tracing study

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Early Overfeeding and Adult Anhedonia: Impact of Neonatal Nutrition on Hedonic Food Regulation in male Rats.

The Journal of Nutritional Biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 109933 - 109933

Published: April 1, 2025

Language: Английский

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(2R,6R)-hydroxynorketamine improves PTSD-associated behaviors and structural plasticity via modulating BDNF-mTOR signaling in the nucleus accumbens

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 335, P. 129 - 140

Published: May 1, 2023

Language: Английский

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Impaired interhemispheric synchrony in Parkinson's disease patients with apathy

Journal of Affective Disorders, Journal Year: 2022, Volume and Issue: 318, P. 283 - 290

Published: Sept. 9, 2022

Language: Английский

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IPAC integrates rewarding and environmental memory during the acquisition of morphine CPP

Science Advances, Journal Year: 2023, Volume and Issue: 9(25)

Published: June 23, 2023

The association between rewarding and drug-related memory is a leading factor for the formation of addiction, yet neural circuits underlying remain unclear. Here, we showed that interstitial nucleus posterior limb anterior commissure (IPAC) integrated environmental information by two different receiving projections from ventral tegmental area (VTA) accumbens shell region (NAcSh) to mediate acquisition morphine conditioned place preference (CPP). A projection VTA GABAergic neurons (VTA GABA ) IPAC lateral (IPACL mediated effect rewarding, whereas pathway NAcSh dopamine receptor 1–expressing (NAcSh D1 medial (IPACM was involved in memory. These findings demonstrated distinct → IPACL D1R IPACM were attributable during CPP, respectively, provided circuit-based potential targets preventing treating opioid addiction.

Language: Английский

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