Tissue and Cell, Journal Year: 2025, Volume and Issue: 94, P. 102774 - 102774
Published: Feb. 5, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: March 14, 2023
Abstract The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition deteriorated disorders. Rejuvenation refers giving aged cells or organisms youthful characteristics through various techniques, such as reprogramming and epigenetic regulation. great leaps in rejuvenation prove that not one-way street, many rejuvenative interventions have emerged delay even reverse the process. Defining mechanism by which roadblocks signaling inputs influence complex programs essential for understanding developing strategies. Here, we discuss intrinsic extrinsic factors counteract cell rejuvenation, targeted core mechanisms involved this Then, critically summarize latest advances state-of-art strategies of rejuvenation. Various methods also provide insights treating specific ageing-related diseases, including reprogramming, removal senescence (SCs) suppression senescence-associated secretory phenotype (SASP), metabolic manipulation, stem cells-associated therapy, dietary restriction, immune heterochronic transplantation, etc. potential applications therapy extend cancer treatment. Finally, analyze detail therapeutic opportunities challenges technology. Deciphering will further into anti-ageing disease treatment clinical settings.
Language: Английский
Citations
79
Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(4), P. 1590 - 1605
Published: Feb. 8, 2023
Abstract Usually, in aerobic metabolism, natural materials including nucleic acids, proteins, and lipids can experience auxiliary injury by oxidative responses. This damage produced reactive oxygen/nitrogen species has been identified as “oxidative stress.” As a polyphenol got from red wine peanuts, resveratrol is one of the most eminent anti‐aging mixtures. Based on many studies', hinders destructive effects inflammatory causes oxygen radicals several tissues. The nuclear erythroid 2‐related factor 2 related to transcription with anti‐inflammatory, antioxidant possessions which complicated enzyme biotransformation biosynthesis carbohydrates. review provides current understanding information about character against stress regulation inflammation via Nrf2 signaling pathway.
Language: Английский
Citations
56
Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(8), P. 1696 - 1710.e10
Published: Aug. 1, 2024
Patients with high ALDH1A3-expressing glioblastoma (ALDH1A3hi GBM) show limited benefit from postoperative chemoradiotherapy. Understanding the mechanisms underlying such resistance in these patients is crucial for development of new treatments. Here, we that interaction between ALDH1A3 and PKM2 enhances latter's tetramerization promotes lactate accumulation stem cells (GSCs). By scanning lactylated proteome lactate-accumulating GSCs, XRCC1 undergoes lactylation at lysine 247 (K247). Lactylated shows a stronger affinity importin α, allowing greater nuclear transposition enhanced DNA repair. Through high-throughput screening small-molecule library, D34-919 potently disrupts ALDH1A3-PKM2 interaction, preventing ALDH1A3-mediated enhancement tetramerization. In vitro vivo treatment chemoradiotherapy-induced apoptosis GBM cells. Together, our findings potential therapeutic target to improve response chemoradiotherapy ALDH1A3hi GBM.
Language: Английский
Citations
37
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 25, 2024
The heightened risk of ionizing radiation exposure, stemming from accidents and potential acts terrorism, has spurred growing interests in devising effective countermeasures against injury. High-dose exposure triggers acute syndrome (ARS), manifesting as hematopoietic, gastrointestinal, neurovascular ARS. Hematopoietic ARS typically presents with neutropenia thrombocytopenia, while gastrointestinal results intestinal mucosal injury, often culminating lethal sepsis bleeding. This deleterious impact can be attributed to radiation-induced DNA damage oxidative stress, leading various forms cell death, such apoptosis, necrosis ferroptosis. Damage-associated molecular patterns (DAMPs) are intrinsic molecules released by cells undergoing injury or the process dying, either through passive active pathways. These then interact pattern recognition receptors, triggering inflammatory responses. Such a cascade events ultimately further tissue organ damage, contributing elevated mortality rate. Notably, infection develop cases, increasing release DAMPs. Given that stands major contributor ARS, DAMPs hold function mediators, exacerbating consequently worsening overall survival. review describes intricate mechanisms underlying Furthermore, it discusses detrimental effects on immune system explores DAMP-targeting therapeutic strategies alleviate
Language: Английский
Citations
17
Cancers, Journal Year: 2023, Volume and Issue: 15(16), P. 4091 - 4091
Published: Aug. 14, 2023
Boron neutron capture therapy (BNCT) is a tumor-selective particle radiotherapy. It combines preferential boron accumulation in tumors and irradiation. The recent initiation of BNCT clinical trials employing hospital-based accelerators rather than nuclear reactors as the source will conceivably pave way for new more numerous trials, leading up to much-needed randomized trials. In this context, it would be interesting consider implementation compounds strategies that significantly optimize BNCT. With aim mind, we analyzed, review, those articles published between 2020 2023 reporting were proved therapeutically useful vitro and/or vivo radiobiological studies, critical step translation setting. We also explored pathologies could potentially treated with newly developed theranostic agents. All these advances intend solve limitations questions arise during patient treatment field, other therapies. sense, active communication clinicians, radiobiologists, all disciplines improve cancer patients, cost- time-effective way.
Language: Английский
Citations
37
Biomolecules, Journal Year: 2023, Volume and Issue: 13(10), P. 1512 - 1512
Published: Oct. 12, 2023
Hormesis implies that the effects of various materials or conditions organisms are exposed to, may not have linear dose-response characteristics but rather, can be biphasic. Thus response to a low dose stressor opposite occurring at higher doses. Such dual is postulated for many toxicants and physical involve beneficial adaptive response. non-linear effect undoubtedly present in useful pharmacological nutraceutical agents with toxic high concentrations. This somewhat divisive topic an area study should objectively studied clouded by political policy considerations. The objective this review examine claims concerning those exposures where hormesis seems exist also there no good supporting evidence. breadth phenomenon potential mechanisms underlying hormetic events discussed together their limitations.
Language: Английский
Citations
28
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6128 - 6128
Published: March 24, 2023
Under physiological and stress conditions, mitochondria act as a signaling platform to initiate biological events, establishing communication from the rest of cell. Mitochondrial adenosine triphosphate (ATP), reactive oxygen species, cytochrome C, damage-associated molecular patterns messengers in metabolism, oxidative response, bystander apoptosis, cellular senescence, inflammation response. In this review paper, mitochondrial response DNA damage was summarized. clearance via fusion, fission, mitophagy regulates quality control under conditions. On other hand, damaged release their contents into cytoplasm then mediate various pathways. The role dysfunction radiation carcinogenesis discussed, recent findings on radiation-induced radioprotective agents that targeted were presented. analysis effect, hypothesized, is critical assessing risks human health.
Language: Английский
Citations
25
Water, Journal Year: 2024, Volume and Issue: 16(11), P. 1483 - 1483
Published: May 23, 2024
The inheritance of historic human-induced disruption and the fierceness its impact change aquatic ecosystems. This work reviews some main stressors on freshwater ecosystems, focusing their effects, threats, risks, protection, conservation, management elements. An overview is provided water protection linked to stressors: solar ultraviolet radiation, thermal pollution, nanoparticles, radioactive salinization, nutrients, sedimentation, drought, extreme floods, fragmentation, pesticides, war terrorism, algal blooms, invasive plants, riparian vegetation, fish. Altogether, these build an exceptionally composite background that are continuously changing ecosystems diminishing or even destroying capability create maintain ongoing natural healthy products essential services humans. Environmental human civilization sustainability cannot exist without proper all over planet; this specific impossible if widespread studied not deeply understood structurally functionally. Without considering each synergisms, Earth’s doomed in terms both quantitative qualitative aspects.
Language: Английский
Citations
15
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 130173 - 130173
Published: Feb. 13, 2024
Language: Английский
Citations
11
ACS Nano, Journal Year: 2024, Volume and Issue: 18(39), P. 26733 - 26750
Published: Sept. 6, 2024
Rescuing or compensating mitochondrial function represents a promising therapeutic avenue for radiation-induced chronic wounds. Adult stem cell efficacies are primarily dependent on the paracrine secretion of mitochondria-containing extracellular vesicles (EVs). However, effective strategies addressing quantity mitochondria and mitochondria-delivery system lacking. Thus, in this study, we aimed to design an hydrogel microneedle patch (MNP) loaded with cell-derived mitochondria-rich EVs gradually release deliver into wound tissues boost healing. We, first, used metformin enhance biogenesis thereby increasing (termed "Met-EVs") adipose-derived cells. To verify effects Met-EVs, established
Language: Английский
Citations
9