COVID-19 Causes Ferroptosis and Oxidative Stress in Human Endothelial Cells

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 326 - 326

Published: Jan. 31, 2023

Oxidative stress and endothelial dysfunction have been shown to play crucial roles in the pathophysiology of COVID-19 (coronavirus disease 2019). On these grounds, we sought investigate impact on lipid peroxidation ferroptosis human cells. We hypothesized that oxidative induced by cells could be linked outcome. Thus, collected serum from patients hospital admission, incubated sera with cells, comparing effects generation reactive oxygen species (ROS) between who survived did not survive. found non-survivors significantly increased peroxidation. Moreover, markedly regulated expression levels main markers ferroptosis, including GPX4, SLC7A11, FTH1, SAT1, a response was rescued silencing TNFR1 Taken together, our data indicate survive triggers

Language: Английский

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Promoting a Syndemic Approach for Cardiometabolic Disease Management During COVID-19: The CAPISCO International Expert Panel

Frontiers in Cardiovascular Medicine, Journal Year: 2021, Volume and Issue: 8

Published: Dec. 15, 2021

Efforts in the fight against COVID-19 are achieving success many parts of world, although progress remains slow other regions. We believe that a syndemic approach needs to be adopted address this pandemic given strong apparent interplay between COVID-19, its related complications, and socio-structural environment. have assembled an international, multidisciplinary group researchers clinical practitioners promote novel COVID-19: CArdiometabolic Panel International experts on Syndemic COvid-19 (CAPISCO). This geographically diverse aims facilitate collaborative-networking scientific exchanges clinicians facing multitude challenges different continents during pandemic. In present article we our "manifesto", with intent provide evidence-based guidance global medical community for better management patients both after current

Language: Английский

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Molecular cross-talk between long COVID-19 and Alzheimer’s disease

GeroScience, Journal Year: 2024, Volume and Issue: 46(3), P. 2885 - 2899

Published: Feb. 23, 2024

Abstract The long COVID (coronavirus disease), a multisystemic condition following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, is one of the widespread problems. Some its symptoms affect nervous system and resemble Alzheimer’s disease (AD)—a neurodegenerative caused by accumulation amyloid beta hyperphosphorylation tau proteins. Multiple studies have found dependence between these two conditions. Patients with greater risk SARS-CoV-2 infection due to increased levels angiotensin-converting enzyme 2 (ACE2), itself promotes generation which enhances AD. Also, molecular pathways are alike—misregulations in folate-mediated one-carbon metabolism, deficit Cq10, disease-associated microglia. Medical imaging both diseases shows decrease volume gray matter, global brain size reduction, hypometabolism parahippocampal gyrus, thalamus, cingulate cortex. In some studies, similar approach applied medication can be seen, including use amino adamantanes phenolic compounds rosemary. significance connections their possible application medical practice still needs further study but there possibility that they will help better understand COVID.

Language: Английский

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Enhanced External Counterpulsation Improves Cognitive Function of Persons with Long COVID

American Journal of Physical Medicine & Rehabilitation, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 3, 2024

ABSTRACT Objective To determine the effects of Enhanced External Counterpulsation (EECP) in patients with long COVID and objectively assessed cognitive impairment. Design A retrospective evaluation referred for EECP, sequela, having completed an objective digital assessment before after therapy. Patients had either impairment (CI) or no (NCI) at baseline. We changes composite score using multi-factor ANOVA. Multiple linear logistic regression analyses were conducted to evaluate several independent variables. Results 80 (38 CI vs 42 NCI) included analyses. All baseline characteristics well matched. There was significant improvement post-EECP those notable documented safety concerns. Conclusion This is first study showing that EECP led functioning defined Although a lack negative control group limitation this study, appears be highly safe effective potential widespread application.

Language: Английский

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Predictive Factors for Difficult Laparoscopic Cholecystectomies in Acute Cholecystitis

Diagnostics, Journal Year: 2024, Volume and Issue: 14(3), P. 346 - 346

Published: Feb. 5, 2024

Laparoscopic cholecystectomy (LC) is the gold standard treatment in acute cholecystitis. However, one six cases expected to be difficult due intense inflammation and suspected adherence involvement of adjacent important structures, which may predispose patients higher risk vascular biliary injuries. In this study, we aimed identify preoperative parameters with predictive value for surgical difficulties. A retrospective study 255 cholecystitis admitted emergency was performed between 2019 2023. Patients laparoscopic (DLC) group experienced more complications compared normal LC (33.3% vs. 15.3%,

Language: Английский

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Circulating Endothelial Cells: A New Possible Marker of Endothelial Damage in Kawasaki Disease, Multisystem Inflammatory Syndrome in Children and Acute SARS-CoV-2 Infection

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(17), P. 10106 - 10106

Published: Sept. 3, 2022

Background: Kawasaki Disease (KD) and Multisystem Inflammatory Syndrome in Children (MIS-C) are pediatric diseases characterized by systemic inflammation vascular injury, potentially leading to coronary artery lesions (CALs). Data on injury occurring during acute COVID-19 (AC19) children still lacking. The aim of our study was investigate endothelial KD-, MIS-C- AC19-dosing circulating cells (CECs). Methods: We conducted a multicenter prospective study. CECs were enumerated CellSearch technology through the immunomagnetic capture CD146-positive from whole blood. Results: enrolled 9 KD, 20 MIS-C 10 AC19. During stage, AC19 KD patients had higher levels than patients. From subacute phase, significant CEC increase observed patients, while mild decrease detected Cellular clusters/syncytia more common No correlation between CALs found incidence group too low this correlation. Conclusions: Our suggests possible role as biomarkers dysfunction different mechanisms these diseases. Further larger studies needed.

Language: Английский

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Neurological Consequences, Mental Health, Physical Care, and Appropriate Nutrition in Long-COVID-19

Cellular and Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 43(5), P. 1685 - 1695

Published: Sept. 14, 2022

SARS-CoV-2 pandemic has caused a collapse of the world health systems. Now, vaccines and more effective therapies have reversed this crisis but scenario is further aggravated by appearance new pathology, occurring as infection consequence: long-COVID-19. This term commonly used to describe signs symptoms that continue or develop after acute COVID-19 up several months. In review, consequences disease on mental neurological implications due long-COVID are described. Furthermore, appropriate nutritional approach some recommendations relieve pathology presented. Data collected indicated in next future will affect an increasing number individuals interdisciplinary action needed counteract it.

Language: Английский

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Noninsulin‐based antihyperglycemic medications in patients with diabetes and COVID‐19: A systematic review and meta‐analysis

Journal of Diabetes, Journal Year: 2023, Volume and Issue: 15(2), P. 86 - 96

Published: Jan. 23, 2023

Abstract Background Patients with diabetes are more likely to suffer COVID‐19 complications. Using noninsulin antihyperglycemic medications (AGMs) during infection has proved challenging. In this study, we evaluate different AGMs in patients COVID‐19. Methods We searched Medline, Embase, Web of Science, and Cochrane on 24 January 2022. used the following keywords (COVID‐19) AND (diabetes mellitus) (antihyperglycemic agent). The inclusion criteria were studies reporting one or outcomes. excluded non‐English articles, case reports, literature reviews. Study outcomes mortality, hospitalization, intensive care unit (ICU) admission. Results use metformin rather than other glucose‐lowering was associated statistically significant lower mortality (risk ratio [RR]: 0.60, 95% confidence interval [CI]: 0.47, 0.77, p < .001). Dipeptidyl peptidase‐4 inhibitor (DPP‐4i) significantly higher hospitalization risk (RR: 1.44, CI: 1.23, 1.68, .001) ICU admissions and/or mechanical ventilation vs nonusers 1.24, 1.04, 1.48, .02). There a decrease for SGLT‐2i users 0.89, 0.84–0.95, Glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) 0.56, 0.42, 073, 0.001), admission, 0.79, 0.69–0.89, .001), 0.73, 0.54, 0.98, = .04). Conclusions AGM not increased mortality. However, GLP‐1RA reduced significantly. DPP‐4i increase admission ICU.

Language: Английский

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Association Between Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) With Diabetic Retinopathy in Type 2 Diabetic Patients

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 9, 2023

Diabetic retinopathy (DR) is one of the main causes blindness worldwide, but an effective screening challenging due to limited available retina specialists. Finding novel biomarkers could help clinical decision in prioritizing ophthalmological consultation patients at risk developing severe DR. This study aims investigate association between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), and presence severity DR with T2DM. A retrospective was performed on 90 T2DM admitted Ophthalmology Clinic, Emergency University Hospital Bucharest Bucharest, Romania, March 2022 2023, for routine cataract surgery. The cases were divided into three groups according DR: no (noDR), non-proliferative diabetic (NPDR), proliferative (PDR) groups. NLR values raised significantly PDR group, group (p = 0.003), NPDR 0.026), while PLR did not differ statistically significant among 0.059). No difference terms age, sex, HbA1C, comorbidities observed. In multivariate analysis, (OR 2.01, [1.29; 3.14], p 0.0019) nephropathy 3.84, [1.23; 11.98], 0.0203) associated higher rates PDR. may be a promising tool stratification

Language: Английский

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Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models

Antioxidants, Journal Year: 2021, Volume and Issue: 10(11), P. 1794 - 1794

Published: Nov. 10, 2021

The COVID-19 pandemic represents an unprecedented global emergency. Despite all efforts, remains a threat to public health, due the complexity of mass vaccination programs, lack effective drugs, and emergence new variants. A link has recently been found between risk developing severe infection high level oxidative stress. In this context, we have focused our attention on natural compounds with aim finding molecules capable acting through dual virucidal-antioxidant mechanism. particular, studied potential grapefruit seed extracts (GSE) their main components, belonging class limonoids. Using chemical biological approaches including isolation purification GSE, antioxidant virucidal assays, shown that constituents, limonoids, are endowed remarkable virucidal, mitoprotective activity.

Language: Английский

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