Senolytics ameliorate the failure of bone regeneration through the cell senescence-related inflammatory signalling pathway DOI Open Access
Xinchen Wang,

Yue Zhou,

Chuyi Luo

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116606 - 116606

Published: April 25, 2024

Stress-induced premature senescent (SIPS) cells induced by various stresses deteriorate cell functions. Dasatinib and quercetin senolytics (DQ) can alleviate several diseases eliminating cells. α-tricalcium phosphate (α-TCP) is a widely used therapeutic approach for bone restoration but induces formation comparatively long time. Furthermore, infection exacerbates the detrimental prognosis of during material implant surgery due to oral cavity bacteria unintentional contamination. It essential mitigate inhibitory effects on surgical procedures. Little known that DQ improves in Lipopolysaccharide (LPS)-contaminated implants its intrinsic mechanisms study maxillofacial defects. This aims investigate whether administration ameliorates impairments repair inflammation contamination SIPS α-TCP LPS-contaminated were implanted into Sprague-Dawley rat calvaria Simultaneously, defects was investigated with or without DQ. Micro-computed tomography hematoxylin-eosin staining showed significantly enhanced at defect site. Histology immunofluorescence revealed levels p21- p16-positive cells, inflammation, macrophages, reactive oxygen species, tartrate-resistant acid phosphatase-positive declined after administering could partially production markers senescence-associated secretory phenotypes vitro. indicates α-TCP-based biomaterials induce cellular senescence hamper regeneration. Senolytics have significant potential reducing adverse osteogenic biomaterial-related infections improving capacity.

Language: Английский

Senoinflammation as the underlying mechanism of aging and its modulation by calorie restriction DOI
Sang Gyun Noh, Hyun‐Woo Kim, Seungwoo Kim

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102503 - 102503

Published: Sept. 1, 2024

Language: Английский

Citations

4
Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation DOI Creative Commons
Z. Zhang, Jiawei Guo

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 38 - 38

Published: Dec. 31, 2024

Oxidative stress plays a pivotal role in the pathogenesis and progression of cardiovascular diseases (CVDs). This review focuses on signaling pathways oxidative during development CVDs, delving into molecular regulatory networks underlying various disease stages, particularly apoptosis, inflammation, fibrosis, metabolic imbalance. By examining dual roles influences sex differences levels susceptibility, this study offers comprehensive understanding diseases. The integrates key findings from current research three ways. First, it outlines major CVDs associated with their respective pathways, emphasizing stress’s central pathology. Second, summarizes protective effects, mechanisms action, animal models antioxidants, offering insights future drug development. Third, discusses applications, advantages, limitations, potential targets gene therapy providing foundation for novel therapeutic strategies. These tables underscore systematic integrative nature while theoretical basis precision treatment CVDs. A contribution is differential effects across different stages addition to proposal innovative, multi-level intervention strategies, which open new avenues system.

Language: Английский

Citations

4
Baicalin-based composite coating for achieving biological multifunctionality of vascular stents DOI

Luying Liu,

Chunhua Fu,

Jingqiao Guo

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 105 - 119

Published: Jan. 8, 2025

Language: Английский

Citations

0
What Is the Impact of Obesity-Related Comorbidities on the Risk of Premature Aging in Patients with Severe Obesity?: A Cross-Sectional Study DOI Creative Commons
Alicja Dudek, Barbara Zapała, Aleksandra Gorostowicz

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 293 - 293

Published: Feb. 8, 2025

Background and Objectives: The relationships between aging, chronic diseases, obesity remain complex poorly understood. This study aimed to investigate the impact of comorbidities on premature aging in individuals with severe obesity. Materials Methods: cross-sectional included 99 bariatric patients (SG) 30 healthy volunteers (HC). SG was further divided into subgroups based comorbidity status. Various markers biological including interleukin-6 (IL-6), C-reactive protein (CRP), telomere length (TL), attention speed, executive functions, metabolic age, were evaluated. Results: Both presented elevated levels IL-6 CRP, shorter TLs, lower outcomes functioning tests, greater age than subjects. However, no significant differences observed without comorbidities. highlighted BMI increased inflammation revealed that hypertension are associated cognitive decline. Conclusions: These findings suggest obesity, regardless comorbidities, contributes aging. presence linked function decline, emphasizing multifaceted implications for process.

Language: Английский

Citations

0
Urolithin as a Metabolite of Ellagitannins and Ellagic Acid from Fruits and Nuts Produced by the Gut Microbiota: Its Role on Non-Communicable Diseases DOI
Márcia Ribeiro, Lívia Alvarenga, L. Cardozo

et al.

Current Nutrition Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 3, 2025

Language: Английский

Citations

0
Melatonin as a treatment for atherosclerosis: focus on programmed cell death, inflammation and oxidative stress DOI Creative Commons

Reza Asemi,

Elham Omidi Najafabadi,

Zahra Gholami Mahmoudian

et al.

Journal of Cardiothoracic Surgery, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 12, 2025

Delaying the development of atherosclerosis (AS) and decreasing cardiac ischemia-reperfusion damage remain serious challenges for medical community. Chronic arterial disease, i.e., AS, is frequently linked to oxidative stress inflammation as significant contributing causes. AS risk factors, such hyperlipidemia, high blood pressure, age, hyperglycemia, smoking, cholesterol, irregular sleep patterns, can exacerbate in carotid artery further shrink its lumen. Finding new approaches that support plaque inhibition or stability an ongoing problem. The last ten years have shown us melatonin (MLT) affects cardiovascular system, although exact mechanisms action are yet unknown. MLT's direct free radical scavenger activity, indirect antioxidant qualities, anti-inflammatory capabilities all contribute atheroprotective effects on several pathogenic signaling pathways. Herein, we examine evidence showing MLT treatment has protective against AS-related diseases. numerous pieces puzzle been epigenetic biogenetic targets prevention therapy atherosclerotic processes identified.

Language: Английский

Citations

0
PCSK9 in Vascular Aging and Age-Related Diseases DOI Creative Commons

Dong Tan,

Xin Yang, Jing Yang

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

The aging process significantly contributes to human disease, and as worldwide life expectancy increases, addressing the challenges of age-related cardiovascular diseases is becoming increasingly urgent. Vascular a key link between development diseases. Recent studies indicate that proprotein convertase subtilisin/kexin type 9 (PCSK9), protein involved in metabolism lipids, crucial modulating vascular by affecting physiological functioning cells. PCSK9 linked lipid chronic inflammation regulating senescence-related activities, including migration, proliferation, apoptosis, differentiation. These factors contribute cells diseases, atherosclerosis, hypertension, coronary artery cerebrovascular Given its involvement these processes, this article provides comprehensive summary PCSK9's regulatory functions aging, highlighting potential therapeutic targets for combating

Language: Английский

Citations

0
Targeted drug delivery systems for atherosclerosis DOI Creative Commons
Liangxing Tu,

Zijian Zou,

Yang Ye

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 23, 2025

Atherosclerosis is a complex cardiovascular disease driven by multiple factors, including aging, inflammation, oxidative stress, and plaque rupture. The progression of this often covert, emphasizing the need for early biomarkers effective intervention measures. In recent years, advancements in therapeutic strategies have highlighted potential targeting specific processes atherosclerosis, such as localization, macrophage activity, key enzymes. Based on this, review discusses role targeted drugs treatment atherosclerosis. It also focuses their clinical efficacy anti-atherosclerosis ability to provide more precise approaches. findings underscore that future research can concentrate exploring newer drug delivery systems further refine enhance long-term dynamic management

Language: Английский

Citations

0
Association between dietary oxidative balance scores and myocardial infarction in diabetic patients: insights from NHANES 1999–2018 DOI Creative Commons
Li Xu,

Yashi Li,

Zehao Jin

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 1, 2025

Myocardial infarction (MI) poses a serious health threat to diabetic patients, who are particularly vulnerable due heightened oxidative stress. The dietary balance score (DOBS) quantifies the overall profile of diet and may reflect diet-related cardiovascular risk. This study aimed evaluate association between DOBS risk MI among individuals using nationally representative U.S. We analyzed data from 5,002 participants in NHANES 1999-2018 cycles. was calculated based on 16 pro- antioxidant nutrients two 24-hour recalls. Logistic regression models 1:1 propensity matching (PSM) were employed assess self-reported history MI, adjusting for demographic, clinical, lifestyle covariates. Restricted cubic spline (RCS) used potential nonlinear relationships. A one-point increase associated with 3% lower odds both unadjusted fully adjusted (adjusted OR = 0.97, 95% CI: 0.95-0.99). Participants highest tertile had 38% compared lowest (OR 0.62, 0.43-0.87), this remained consistent matched cohort 0.72, 0.48-0.88). While formal tests nonlinearity not significant, RCS curves suggested threshold effect diminishing benefits at higher levels. Subgroup sensitivity analyses confirmed robustness findings. Higher is likelihood patients. These findings highlight value antioxidant-rich patterns assessment. However, given geographic cultural variability diet, further validation needed diverse populations prospective settings.

Language: Английский

Citations

0
Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis DOI Open Access
Rafael Ramı́rez, Noemí Ceprián, Andrea Figuer

et al.

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(2), P. 215 - 215

Published: Feb. 4, 2022

Atherosclerosis is probably one of the paradigms disease linked to aging. Underlying physiopathology atherosclerosis are cellular senescence, oxidative stress, and inflammation. These factors increased in elderly from chronic patients. Elevated levels stress affect function metabolism, inducing senescence. This senescence modifies cell phenotype into a senescent secretory phenotype. activates immune cells, leading systemic Moreover, due their phenotype, cells present an release highlighted extracellular vesicles that will change nearby/neighborhood paracrine signaling. For this reason, searching for specific biomarkers therapies against development/killing has become relevant. Recently, senomorphic senolityc drugs have relevant slowing down or eliminating cells. However, even though they shown promising results experimental studies, clinical use still yet be determined.

Language: Английский

Citations

15