Enhanced hemostatic efficacy of cryogel with copper ion-loaded mesoporous bioactive glasses for acute and persistent bleeding DOI Creative Commons
Qixiu Hou, Xu He,

Mengting Guo

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 12, 2025

Uncontrolled acute and persistent bleeding, as well with infection, is a great challenge because of the high mortality during treating patients injuries, complex surgery or bone marrow failure. Here, we develop an external form natural components which based on phosphorylated methacrylated gelatin (GelMA, G) cryogel (GP) loaded tannic acid (TA)-mixed copper ion (Cu2+) mesoporous bioactive glasses (MBG), named after GP@MBG-Cu-TA cryogel, to address goals reduce bleeding enhance antibacterial activity. Structurally, GP, MBG TA Cu2+ adheres GP via hydrogen bonding. In vitro, displays good biocompatibility, hemostatic antimicrobial capability. vivo studies, can effect in liver injury SD rats for aplastic anemia hemophilia A mice tail amputation bleeding. addition, accelerates skin wound repair bacterial contamination at site. sum, not only endowed dual function capability, but also stop objects either normal abnormal coagulation function. Thus, provides promising candidate dressing managing complications clinic.

Language: Английский

The role of macrophage polarization in rheumatoid arthritis and osteoarthritis: Pathogenesis and therapeutic strategies DOI

Jun‐Way Chang,

Chih‐Hsin Tang

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113056 - 113056

Published: Aug. 31, 2024

Language: Английский

Citations

9
Revealing the impact of tadalafil-loaded proniosomal gel against dexamethasone-delayed wound healing via modulating oxido-inflammatory response and TGF-β/Macrophage activation pathway in rabbit model DOI Creative Commons

Nermin A. Helmy,

Elsayed A. Abdel Aziz,

Mustafa Abd El Raouf

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0315673 - e0315673

Published: Jan. 7, 2025

A serious challenge of the chronic administration dexamethasone (DEX) is a delay in wound healing. Thus, this study aimed to investigate potential Tadalafil (TAD)-loaded proniosomal gel accelerate healing process skin wounds DEX-challenged rabbits. Skin were induced 48 rabbits 4 groups (n = 12 per group) and treated by sterile saline (control), TAD-loaded topically on wound, DEX-injected rabbits, DEX+TAD-loaded for weeks. The optical photography, transmission electron microscopy, vitro release profile, stability studies revealed successful preparation selected formula with good stability. DEX was associated uncontrolled oxido-inflammatory reactions, suppression immune response wounds, consequently failure process. gel-treated manifested marked enhancement rate closure than control (p < 0.05). successfully antagonized impacts dampening MDA production, enhancing total antioxidant capacity, coupled modulation inflammatory-related genes, inducible nitric oxide synthase, tumor necrosis factor-alpha, interleukin-1β, matrix metalloproteinase 9, during all stages This combination significant amplification response-related CD68 CD163 Moreover, histopathological, Masson’s Trichrome-stain, immune-histochemical indicated tissue recovery formation new blood vessels gel, as well-organized collagen fibers, upregulation transforming growth factor β1, vascular endothelial expression tissues Overall, topical application useful improving delayed linked therapy via regulating inflammatory/macrophage activation mediators enhanced angiogenesis, vascularity.

Language: Английский

Citations

1
Spleen tyrosine kinase aggravates intestinal inflammation through regulating inflammatory responses of macrophage in ulcerative colitis DOI Creative Commons
Leilei Chen,

Fengqin Zhu,

Xizhuang Gao

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114122 - 114122

Published: Jan. 24, 2025

Language: Английский

Citations

1
NLRP3 inflammasome promotes functional repair after spinal cord injury in mice by regulating autophagy and its mechanism DOI
Haozhe Tian, Juan Zheng, Fangli Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 149, P. 114230 - 114230

Published: Feb. 7, 2025

Language: Английский

Citations

1
Enhanced hemostatic efficacy of cryogel with copper ion-loaded mesoporous bioactive glasses for acute and persistent bleeding DOI Creative Commons
Qixiu Hou, Xu He,

Mengting Guo

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 12, 2025

Uncontrolled acute and persistent bleeding, as well with infection, is a great challenge because of the high mortality during treating patients injuries, complex surgery or bone marrow failure. Here, we develop an external form natural components which based on phosphorylated methacrylated gelatin (GelMA, G) cryogel (GP) loaded tannic acid (TA)-mixed copper ion (Cu2+) mesoporous bioactive glasses (MBG), named after GP@MBG-Cu-TA cryogel, to address goals reduce bleeding enhance antibacterial activity. Structurally, GP, MBG TA Cu2+ adheres GP via hydrogen bonding. In vitro, displays good biocompatibility, hemostatic antimicrobial capability. vivo studies, can effect in liver injury SD rats for aplastic anemia hemophilia A mice tail amputation bleeding. addition, accelerates skin wound repair bacterial contamination at site. sum, not only endowed dual function capability, but also stop objects either normal abnormal coagulation function. Thus, provides promising candidate dressing managing complications clinic.

Language: Английский

Citations

1