INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine),
Journal Year:
2024,
Volume and Issue:
20(2), P. 133 - 142
Published: April 19, 2024
In
recent
years,
there
has
been
an
interest
in
studying
the
specifics
of
relationships
between
metabolic
syndrome
(MetS),
sleep
disorders
and
melatonin
(MEL).
Dyssomnia
insomnia
are
important
risk
factors
for
insulin
resistance,
obesity,
MetS,
type
2
diabetes
mellitus
with
a
degree
influence
similar
to
traditional
factors.
Thus,
treatment
dyssomnia
is
one
key
tasks
prevention
MetS.
The
regulation
circadian
rhythms
by
exogenous
intervention
(in
particular,
use
melatonergic
drugs)
likely
play
central
role
MEL
acts
as
powerful
antioxidant
that
can
cross
blood-brain
barrier,
suppress
oxidative
stress,
chronic
inflammation,
interact
gut
microbiome.
From
clinical
point
view,
imbalance
may
indicate
“darkness
deficit”.
It
proven
neurohormone
systemic
effects
due
its
mechanisms
action,
potential
course
many
diseases.
Currently,
drugs
approved
exclusively
insomnia,
jetlag,
depression
accompanied
disorders.
However,
potentially
therapeutic
properties
neurodegenerative
diseases,
post-traumatic
stress
disorder,
neuropsychiatric
disorders,
dementia,
autoimmune
allergic
increasing
need
products
prompted
search
safe
but
environmentally
friendly
medicines.
reported
phytomelatonin
have
advantages
related
improved
bioavailability
efficacy.
purpose
this
review
analyze
relationship
dyssomnia,
MEL.
was
conducted
Scopus,
Science
Direct
(from
Elsevier),
PubMed,
including
MEDLINE
databases.
keywords
used
were
“metabolic
syndrome”,
“dyssomnia”,
“insomnia”,
“obstructive
apnea”,
“melatonin”.
We
manual
bibliography
publications
identify
research
results
eluded
during
online
search.
Frontiers in Physiology,
Journal Year:
2023,
Volume and Issue:
14
Published: April 25, 2023
Mitochondria
play
a
key
role
in
both
health
and
disease.
Their
function
is
not
limited
to
energy
production
but
serves
multiple
mechanisms
varying
from
iron
calcium
homeostasis
the
of
hormones
neurotransmitters,
such
as
melatonin.
They
enable
influence
communication
at
all
physical
levels
through
interaction
with
other
organelles,
nucleus,
outside
environment.
The
literature
suggests
crosstalk
between
mitochondria
circadian
clocks,
gut
microbiota,
immune
system.
might
even
be
hub
supporting
integrating
activity
across
these
domains.
Hence,
they
(missing)
link
Mitochondrial
dysfunction
related
metabolic
syndrome,
neuronal
diseases,
cancer,
cardiovascular
infectious
inflammatory
disorders.
In
this
regard,
diseases
Alzheimer’s,
Parkinson’s,
amyotrophic
lateral
sclerosis
(ALS),
chronic
fatigue
syndrome
(CFS),
pain
are
discussed.
This
review
focuses
on
understanding
mitochondrial
action
that
allow
for
maintenance
pathways
toward
dysregulated
mechanisms.
Although
have
allowed
us
adapt
changes
over
course
evolution,
turn,
evolution
has
shaped
mitochondria.
Each
evolution-based
intervention
influences
its
own
way.
use
physiological
stress
triggers
tolerance
stressor,
achieving
adaptability
resistance.
describes
strategies
could
recover
functioning
providing
comprehensive,
root-cause-focused,
integrative
approach
recovering
treating
people
suffering
diseases.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(19), P. 3934 - 3934
Published: Sept. 22, 2022
Melatonin
has
become
a
popular
dietary
supplement,
most
known
as
chronobiotic,
and
for
establishing
healthy
sleep.
Research
over
the
last
decade
into
cancer,
Alzheimer’s
disease,
multiple
sclerosis,
fertility,
PCOS,
many
other
conditions,
combined
with
COVID-19
pandemic,
led
to
greater
awareness
of
melatonin
because
its
ability
act
potent
antioxidant,
immune-active
agent,
mitochondrial
regulator.
There
are
distinct
similarities
between
vitamin
D
in
depth
breadth
their
impact
on
health.
Both
hormones,
affect
systems
through
immune-modulating,
anti-inflammatory
functions,
found
skin,
responsive
sunlight
darkness.
In
fact,
there
may
be
widespread
concern
about
deficiency
“sunlight
deficiency”
reduced
secretion
result
“darkness
from
overexposure
artificial
blue
light.
The
trend
toward
use
supplements
resulted
safety,
especially
higher
doses,
long-term
use,
application
certain
populations
(e.g.,
children).
This
review
aims
evaluate
recent
data
melatonin’s
mechanisms,
clinical
uses
beyond
sleep,
safety
concerns,
thorough
summary
therapeutic
considerations
concerning
supplementation,
including
different
formats
available
(animal,
synthetic,
phytomelatonin),
dosing,
timing,
contraindications,
nutrient
combinations.
Journal of Biological Rhythms,
Journal Year:
2024,
Volume and Issue:
39(2), P. 135 - 165
Published: Feb. 16, 2024
It
has
been
50
years
since
the
suprachiasmatic
nucleus
(SCN)
was
first
identified
as
central
circadian
clock
and
25
last
overview
of
developments
in
field
published
Journal
Biological
Rhythms.
Here,
we
explore
new
mechanisms
concepts
that
have
emerged
subsequent
years.
Since
1997,
methodological
developments,
such
luminescent
fluorescent
reporter
techniques,
revealed
intricate
relationships
between
cellular
network-level
mechanisms.
In
particular,
specific
neuropeptides
arginine
vasopressin,
vasoactive
intestinal
peptide,
gastrin-releasing
peptide
key
players
synchronization
rhythms
within
SCN.
The
discovery
multiple
oscillators
governing
behavioral
physiological
significantly
advanced
our
understanding
clock.
interaction
neurons
glial
cells
found
to
play
a
crucial
role
regulating
these
Furthermore,
properties
SCN
network
vary
across
ontogenetic
stages.
application
cell
type–specific
genetic
manipulations
components
functional
input-output
system
their
correlation
with
functions.
This
review
concludes
high-risk
effort
identifying
open
questions
challenges
lie
ahead.
Annual Review of Vision Science,
Journal Year:
2023,
Volume and Issue:
9(1), P. 245 - 267
Published: May 17, 2023
We
live
on
a
planet
that
is
bathed
in
daily
and
seasonal
sunlight
cycles.
In
this
context,
terrestrial
life
forms
have
evolved
mechanisms
directly
harness
light
energy
(plants)
or
decode
information
for
adaptive
advantage.
animals,
the
main
sensors
are
family
of
G
protein-coupled
receptors
called
opsins.
Opsin
function
best
described
visual
sense.
However,
most
animals
also
use
opsins
extraocular
sensing
behavior
camouflage.
While
it
has
long
been
believed
mammals
do
not
an
capacity,
recent
evidence
suggests
otherwise.
Notably,
encephalopsin
(OPN3)
neuropsin
(OPN5)
both
known
to
mediate
mice.
Examples
mediation
include
photoentrainment
circadian
clocks
skin
(by
OPN5)
acute
light-dependent
regulation
metabolic
pathways
OPN3
OPN5).
This
review
summarizes
current
findings
expanding
field
photoreception
their
relevance
human
physiology.
Frontiers in Physiology,
Journal Year:
2022,
Volume and Issue:
13
Published: April 27, 2022
Circadian
rhythms
convergently
evolved
to
allow
for
optimal
synchronization
of
individuals’
physiological
and
behavioral
processes
with
the
Earth’s
24-h
periodic
cycling
environmental
light
temperature.
Whereas
suprachiasmatic
nucleus
(SCN)
is
considered
primary
pacemaker
mammalian
circadian
system,
many
extra-SCN
oscillatory
brain
regions
have
been
identified
not
only
exhibit
sustainable
in
molecular
clock
function,
but
also
overall
region
activity/function
mediated
behaviors.
In
this
review,
we
present
most
recent
evidence
ventral
tegmental
area
(VTA)
accumbens
(NAc)
serve
as
oscillators
highlight
studies
that
illustrate
functional
significance
VTA’s
NAc’s
inherent
properties
they
relate
reward-processing,
drug
abuse,
vulnerability
develop
substance
use
disorders
(SUDs).
Physiological Reviews,
Journal Year:
2023,
Volume and Issue:
103(3), P. 2231 - 2269
Published: Feb. 2, 2023
Salt-inducible
kinases
(SIKs),
which
comprise
a
family
of
three
homologous
serine-threonine
kinases,
were
first
described
for
their
role
in
sodium
sensing
but
have
since
been
shown
to
regulate
multiple
aspects
physiology.
These
are
activated
or
deactivated
response
extracellular
signals
that
cell
surface
receptor
mediated
and
go
on
phosphorylate
targets
including
the
transcription
cofactors
CRTC1-3
class
IIa
histone
deacetylases
(HDACs).
Thus,
SIK
conveys
about
cellular
environment
reprogram
transcriptional
posttranscriptional
processes
response.
In
this
manner,
SIKs
metabolic
responses
feeding/fasting,
division
oncogenesis,
inflammation,
immune
responses,
most
recently,
sleep
circadian
rhythms.
Sleep
rhythms
master
regulators
physiology
exquisitely
sensitive
regulation
by
environmental
light
physiological
such
as
need
sleep.
be
central
molecular
both
these
processes.
Here,
we
summarize
mechanisms
control
different
domains
highlight
where
there
is
mechanistic
overlap
with
sleep/circadian
rhythm
control.
BMC Microbiology,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: May 9, 2023
Abstract
Background
Circadian
rhythms,
observed
across
all
domains
of
life,
enable
organisms
to
anticipate
and
prepare
for
diel
changes
in
environmental
conditions.
In
bacteria,
a
circadian
clock
mechanism
has
only
been
characterized
cyanobacteria
date.
These
clocks
regulate
cyclical
patterns
gene
expression
metabolism
which
contribute
the
success
their
natural
environments.
The
potential
impact
self-generated
rhythms
other
bacterial
microbial
populations
motivated
extensive
research
identify
novel
clocks.
Main
text
Daily
oscillations
community
composition
function
have
ocean
ecosystems
symbioses.
are
influenced
by
abiotic
factors
such
as
light
availability
nutrients.
some
marine
symbioses,
largely
controlled
light-dark
cycles.
gut
systems,
influx
nutrients
after
host
feeding
drastically
alters
microbiota.
Conversely,
microbiota
can
influence
rhythm
variety
mechanisms
including
through
interacting
with
immune
system.
intricate
complex
relationship
between
makes
it
challenging
disentangle
behaviors
from
that
might
govern
daily
these
populations.
Conclusions
While
ability
would
likely
be
enhanced
self-sustained
rhythm,
more
evidence
further
studies
needed
confirm
whether
host-associated
heterotrophic
bacteria
possess
systems.
addition,
respond
cycles
conditions
yet
uncovered.
npj Microgravity,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: April 3, 2023
The
circadian
clock
regulates
cellular
and
molecular
processes
in
mammals
across
all
tissues
including
skeletal
muscle,
one
of
the
largest
organs
human
body.
Dysregulated
rhythms
are
characteristic
aging
crewed
spaceflight,
associated
with,
for
example,
musculoskeletal
atrophy.
Molecular
insights
into
spaceflight-related
alterations
regulation
muscle
still
missing.
Here,
we
investigated
potential
functional
consequences
disruptions
on
using
published
omics
datasets
obtained
from
spaceflights
other
clock-altering,
external
(fasting
exercise),
or
internal
(aging)
conditions
Earth.
Our
analysis
identified
network
muscle-associated
pathways,
as
a
result
spaceflight
duration
mice,
which
resembles
aging-related
gene
expression
changes
observed
humans
Earth
(e.g.,
ATF4
downregulation,
with
atrophy).
Furthermore,
according
to
our
results,
factors
such
exercise
fasting
lead
core-clock
network,
may
compensate
disruption
during
spaceflights.
Thus,
maintaining
functioning
is
crucial
ameliorate
unphysiological
atrophy
reported
among
astronauts.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(4), P. 959 - 959
Published: April 19, 2023
Metabolic
syndrome
has
been
associated
in
many
studies
with
working
shifts.
Even
if
the
mechanistic
details
are
not
fully
understood,
forced
sleep
deprivation
and
exposure
to
light,
as
happens
during
night
shifts,
or
irregular
schedules
late
very
early
onset
of
program,
lead
a
sleep–wake
rhythm
misalignment,
metabolic
dysregulation
oxidative
stress.
The
cyclic
melatonin
secretion
is
regulated
by
hypothalamic
suprachiasmatic
nuclei
light
exposure.
At
central
level,
promotes
inhibits
wake-signals.
Beside
this
role,
acts
an
antioxidant
influences
functionality
cardiovascular
system
different
processes.
This
review
presents
data
about
influence
shifts
on
Assembling
from
epidemiological,
experimental
clinical
contributes
better
understanding
pathological
links
between
chronodisruption
related