Mechanisms of postischemic cardiac death and protection following myocardial injury

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(1)

Published: Jan. 1, 2025

Acute myocardial infarction (MI) is a leading cause of death worldwide. Although with current treatment, acute mortality from MI low, the damage and remodeling associated are responsible for subsequent heart failure. Reducing cell would decrease Despite considerable study, precise mechanism by which ischemia reperfusion (I/R) trigger still not fully understood. In this Review, we summarize changes that occur during I/R injury, emphasis on those might initiate death, such as calcium overload oxidative stress. We review cell-death pathways pathway crosstalk discuss cardioprotective approaches in order to provide insight into mechanisms could be targeted therapeutic interventions. Finally, clinical trials, focus possible reasons why they were successful. Cardioprotection has largely focused inhibiting single or one death-trigger (calcium ROS). treatment other diseases, cancer, benefit targeting multiple "drug cocktail" approach been demonstrated. Given between pathways, cardiac should considered.

Language: Английский

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Clinical Application of Serum microRNAs in Atherosclerotic Coronary Artery Disease

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(22), P. 6849 - 6849

Published: Nov. 20, 2022

MicroRNAs (miRs) are promising diagnostic, prognostic and therapeutic biomolecules for atherosclerotic cardiovascular disease. Atherosclerotic occlusive disease concerns a large population of patients, carrying the highest incidence fatal non-fatal adverse events, such as myocardial infarction, ischemic stroke, limb ischemia, worldwide. Consistently, miRs involved in regulation pathogenesis coronary artery (CAD), acute syndromes (ACS), both with ST-segment (STEMI) non-ST segment elevation infarctions (NSTEMI), well cardiac remodeling fibrosis following ACS. However, genetic molecular mechanisms underlying outcomes CAD multifactorial, sometimes difficult to interpret clinicians. Therefore, present review paper we have focused on clinical meaning interpretation various findings, their potential application routine practice.

Language: Английский

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Epigenetics in Precision Nutrition

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(4), P. 533 - 533

Published: March 28, 2022

Precision nutrition is an emerging area of research, with primary focus on the individual variability in response to dietary and lifestyle factors, which are mainly determined by individual’s intrinsic variations, such as those genome, epigenome, gut microbiome. The current research precision heavily focused genome microbiome, while epigenome (DNA methylation, non-coding RNAs, histone modification) largely neglected. acts interface between human environmental stressors, including diets lifestyle. Increasing evidence has suggested that epigenetic modifications, particularly DNA may determine metabolic health factors and, therefore, hold great promise discovering novel markers for potential targets interventions. This review summarized recent studies methylation obesity, diabetes, cardiovascular disease, more emphasis put relations diet/lifestyle We also briefly reviewed other events, relation nutrition, discussed role epigenetics research.

Language: Английский

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Is miR-21 A Therapeutic Target in Cardiovascular Disease?

International Journal of Drug Discovery and Pharmacology, Journal Year: 2023, Volume and Issue: unknown, P. 26 - 36

Published: Jan. 11, 2023

microRNA-21 (miR-21) serves a multitude of functions at the molecular level through its regulation messenger RNA. Previous research has sparked interest in role miR-21 as potential therapeutic target cardiovascular diseases. expression contributes to differentiation, proliferation, and maturation many cell types, such fibroblasts, endothelial cells, cardiomyocytes, progenitor cells. The function depends upon specific types downstream targets, which determine fate. Under pathological conditions, is altered, leading abnormal gene signaling diseases hypertension, cardiac hypertrophy fibrosis, atherosclerosis, heart failure. Agomirs or antagomirs can be introduced into respective tissue type reverse stop progression disease. Exosomes extracellular vesicles, mediate cellular events with high biocompatibility, have efficiently delivering their targeted critical disease (CVD) indisputable, but there are controversial reports on same This discrepancy sparks better understanding different tissues under stages various mechanism how inhibitors work.

Language: Английский

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Overview of Injectable Hydrogels for the Treatment of Myocardial Infarction

Cardiovascular Innovations and Applications, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 1, 2024

Myocardial infarction (MI) triggers adverse remodeling mechanisms, thus leading to heart failure. Since the application of biomaterial-based scaffolds emerged as a viable approach for providing mechanical support and promoting cell growth, injectable hydrogels have garnered substantial attention in MI treatment because their minimally invasive administration through injection diminished risk infection. To fully understand interplay between infarcted myocardium repair, this review provides an overview recent advances hydrogel-mediated therapy, including: I) material designs repairing myocardium, considering pathophysiological mechanism design principles biomaterials treatment; II) development functional treatment, including conductive, self-healing, drug-loaded, stimulus-responsive hydrogels; III) research progress using restore cardiac function by neovascularization, enhancing cardiomyocyte proliferation, decreasing myocardial fibrosis, inhibiting excessive inflammation. Overall, presents current state hydrogel offering valuable information facilitate interdisciplinary knowledge transfer enable prognostic markers suitable materials.

Language: Английский

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Applications of transcriptomics in ischemia reperfusion research in lung transplantation

The Journal of Heart and Lung Transplantation, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

Abstract

Ischemia-reperfusion (IR) injury contributes to primary graft dysfunction, a major cause of early mortality after lung transplantation. Transcriptomics uses high-throughput techniques profile the RNA transcripts within sample and provides unique view mechanisms underlying various biological processes. This review aims highlight applications transcriptomics in IR studies, which have thus far revealed inflammatory responses be event activated by IR, identified potential biomarkers therapeutic targets, investigated interventions. Ex vivo perfusion, together with advanced bioinformatic transcriptomic techniques, including single-cell RNA-sequencing, microRNA profiling, multi-omics, continue expand capabilities transcriptomics. In future, construction biospecimen banks promotion international collaborations among clinicians researchers advance our understanding improve management transplant recipients.

Language: Английский

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Investigating miRNA subfamilies: Can they assist in the early diagnosis of acute myocardial infarction?

Drug Discovery Today, Journal Year: 2023, Volume and Issue: 28(10), P. 103695 - 103695

Published: July 4, 2023

Language: Английский

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Critical analysis of descriptive microRNA data in the translational research on cardioprotection and cardiac repair: lost in the complexity of bioinformatics

Basic Research in Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

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miR-21 in cardiovascular disease: new insights and emerging therapeutic potential

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(5)

Published: May 3, 2025

Language: Английский

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Au@16-pH-16/miR-21 mimic nanosystem: An efficient treatment for obesity through browning and thermogenesis induction

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 171, P. 116104 - 116104

Published: Jan. 9, 2024

Despite the abundance of registered clinical trials worldwide, availability effective drugs for obesity treatment is limited due to their associated side effects. Thus, there growing interest in therapies that stimulate energy expenditure white adipose tissue. Recently, we demonstrated delivery a miR-21 mimic using JetPEI effectively inhibits weight gain an obese mouse model by promoting metabolism, browning, and thermogenesis, suggesting potential as obesity. these promising results, implementation more advanced system techniques would greatly enhance advancement safe efficient approaches individuals with future. Our objective explore whether new based on gold nanoparticles Gemini surfactants (Au@16-ph-16) can replicate favorable effects gain, thermogenesis. We found dosages low 0.2 μg /animal significantly inhibited induced browning thermogenic parameters. This was evidenced upregulation specific genes proteins processes, well biogenesis beige adipocytes mitochondria. Significant increases levels were observed tissue but not other types. data indicates Au@16-ph-16 could serve miRNA mimics, its suitability development future treatments against

Language: Английский

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