Bacterial Cellulose and Its Applications

Polymers, Journal Year: 2022, Volume and Issue: 14(6), P. 1080 - 1080

Published: March 8, 2022

The sharp increase in the use of cellulose seems to be increasing demand wood; much more research related sustainable or alternative materials is necessary as a lot arable land and natural resources unsustainable. In accordance, attention has focused on bacterial new functional material. It possesses three-dimensional, gelatinous structure consisting with mechanical thermal properties. Moreover, while plant-originated composed cellulose, hemi-cellulose, lignin, attributable composition pure nanofiber mesh spun not elimination other components. due its hydrophilic nature caused by binding water, consequently being hydrogel well biocompatibility, it only used medical fields including artificial skin, cartilage, vessel, wound dressing, but also delivery; some products have even been commercialized. addition, widely various technologies food, paper, textile, electronic electrical applications, considered highly versatile green material tremendous potential. However, many efforts conducted for evolution novel sophisticated environmental affinity, which accompany empowerment enhancement specific this review article, we summarized industry status regarding BC contemplated potential BC.

Language: Английский

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Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

Genes & Diseases, Journal Year: 2023, Volume and Issue: 11(1), P. 189 - 204

Published: Jan. 14, 2023

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology, as it represents a major obstacle to effective cancer treatment. Since cells are highly diverse at genetic, epigenetic, and phenotypic levels, intra-tumor can be assumed an important contributing factor nullification chemotherapeutic effects, recurrence tumor. Based on role heterogeneous subpopulations with varying cell-cycle dynamics behavior during progression treatment; herein, we aim establish comprehensive definition for adaptation neoplastic against therapy. We discuss two parallel yet distinct that play pivotal roles reducing effects chemotherapy: "resistant" "tolerant" populations. Furthermore, this review also highlights impact quiescent phase cell cycle survival mechanism cells. Beyond understanding mechanisms underlying quiescence, provides insightful perspective stem (CSCs) their dual intertwined functions based state response Moreover, CSCs, epithelial–mesenchymal transformed cells, circulating (CTCs), disseminated (DTCs), which mostly proved have multiple biological links implicated our viewpoint tumors. Overall, increasing knowledge key identifying new therapeutic solutions, emerging concept may provide us opportunities prevent dreadful recurrence.

Language: Английский

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Simulation-based approaches for drug delivery systems: Navigating advancements, opportunities, and challenges

Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 395, P. 123888 - 123888

Published: Dec. 27, 2023

Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals' targeted and effective administration. However, the intricate interplay between formulations poses challenges their design optimization. Simulations have emerged as indispensable tools for comprehending these interactions enhancing DDS performance to address this complexity. This comprehensive review explores latest advancements simulation techniques provides detailed analysis. The encompasses various methodologies, including molecular dynamics (MD), Monte Carlo (MC), finite element analysis (FEA), computational fluid (CFD), density functional theory (DFT), machine learning (ML), dissipative particle (DPD). These are critically examined context of research. article presents illustrative case studies involving liposomal, polymer-based, nano-particulate, implantable DDSs, demonstrating influential simulations optimizing systems. Furthermore, addresses advantages limitations It also identifies future directions research development, such integrating multiple techniques, refining validating models greater accuracy, overcoming limitations, exploring applications personalized medicine innovative DDSs. employing like MD, MC, FEA, CFD, DFT, ML, DPD offer crucial insights into behaviour, aiding Despite advantages, rapid cost-effective screening, require validation addressing limitations. Future should focus on models, enhance outcomes. paper underscores contribution emphasizing providing valuable facilitating development optimization ultimately patient As we continue explore impact advancing discovery improving DDSs is expected be profound.

Language: Английский

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Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress

Reproductive Toxicology, Journal Year: 2023, Volume and Issue: 118, P. 108369 - 108369

Published: March 24, 2023

Language: Английский

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Natural products for combating multidrug resistance in cancer

Pharmacological Research, Journal Year: 2024, Volume and Issue: 202, P. 107099 - 107099

Published: Feb. 10, 2024

Cancer cells frequently develop resistance to chemotherapeutic therapies and targeted drugs, which has been a significant challenge in cancer management. With the growing advances technologies isolation identification of natural products, potential products combating multidrug received substantial attention. Importantly, can impact multiple targets, be valuable overcoming drug from different perspectives. In current review, we will describe well-established mechanisms underlying resistance, introduce that could target these resistant mechanisms. Specifically, discuss compounds such as curcumin, resveratrol, baicalein, chrysin more, their roles resistance. This review article aims provide systematic summary recent rationales for novel discovery.

Language: Английский

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Combination Anticancer Therapies Using Selected Phytochemicals

Molecules, Journal Year: 2022, Volume and Issue: 27(17), P. 5452 - 5452

Published: Aug. 25, 2022

Cancer is still one of the most widespread diseases globally, it considered a vital health challenge worldwide and main barriers to long life expectancy. Due potential toxicity lack selectivity conventional chemotherapeutic agents, discovering alternative treatments top priority. Plant-derived natural products have high in cancer treatment due their multiple mechanisms action, diversity structure, availability nature, relatively low toxicity. In this review, anticancer common phytochemicals were analyzed. Furthermore, detailed discussion effect combinations consisting product or with drugs was provided. This review should provide strong platform for researchers clinicians improve basic clinical research development medicines.

Language: Английский

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Cytoprotective remedies for ameliorating nephrotoxicity induced by renal oxidative stress

Life Sciences, Journal Year: 2023, Volume and Issue: 318, P. 121466 - 121466

Published: Feb. 10, 2023

Nephrotoxicity is the hallmark of anti-neoplastic drug metabolism that causes oxidative stress. External chemical agents and prescription drugs release copious amounts free radicals originating from molecular oxidation unless sustainably scavenged, they stimulate membrane lipid peroxidation disruption host antioxidant mechanisms. This review aims to provide a comprehensive collection potential cytoprotective remedies in surmounting most difficult aspect cancer therapy as well preventing renal stress by other means. Over 400 published research articles spanning several decades were scrutinised obtain relevant data which presented 3 categories; sources, mechanisms, mitigation Drug chemical-induced nephrotoxicity commonly manifests chronic or acute kidney disease, nephritis, nephrotic syndrome, nephrosis. Renal replacement requirements mortalities end-stage disease are set rapidly increase next decade for 43 different compounds have capability suppress experimental described. The system performs essential homeostatic functions play significant role eliminating toxicants, its accumulation recurrence nephric tissues results tubular degeneration subsequent impairment. Global statistics latest prevalence 13.4 % while requiring 4–7 million per annum. remedial discussed herein had proven efficacy against manifested consequent impaired mechanisms preclinical models produced activators.

Language: Английский

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Hydrogel Tissue Bioengineered Scaffolds in Bone Repair: A Review

Molecules, Journal Year: 2023, Volume and Issue: 28(20), P. 7039 - 7039

Published: Oct. 12, 2023

Large bone defects due to trauma, infections, and tumors are difficult heal spontaneously by the body’s repair mechanisms have become a major hindrance people’s daily lives economic development. However, autologous allogeneic grafts, with their lack of donors, more invasive surgery, immune rejection, potential viral transmission, hinder development repair. Hydrogel tissue bioengineered scaffolds gained widespread attention in field good biocompatibility three-dimensional network structure that facilitates cell adhesion proliferation. In addition, loading natural products nanoparticles incorporating them into hydrogel is one most effective strategies promote bioactivity limitations products. Therefore, this paper presents brief review application hydrogels different gel-forming properties, matrices, nanoparticle-loaded loaded incorporated for defect recent years.

Language: Английский

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Polyphenol-Loaded Nano-carriers for Breast Cancer Therapy: A Comprehensive Review

BioNanoScience, Journal Year: 2024, Volume and Issue: 14(4), P. 4219 - 4237

Published: Jan. 10, 2024

Language: Английский

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Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer properties

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 268, P. 116249 - 116249

Published: Feb. 23, 2024

Cancer encompasses a group of pathologies with common characteristics, high incidence, and prevalence in all countries. Although there are treatments available for this disease, they not always effective or safe, often failing to achieve the desired results. This is why it necessary continue search new therapies. One strategies obtaining antitumor drugs use 1,4-naphthoquinone as scaffold synthetic natural products activity. review focuses on compiling studies related activity its derivatives over last 10 years. The work describes main naphthoquinones classifies based structural modifications made scaffold. Additionally, formation metal complexes using ligand considered. After thorough review, 197 compounds potent biological against cancer have been classified according their chemical structures mechanisms action described.

Language: Английский

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