Phytomedicine, Journal Year: 2024, Volume and Issue: 127, P. 155473 - 155473
Published: Feb. 21, 2024
Language: Английский
Trends in Pharmacological Sciences, Journal Year: 2022, Volume and Issue: 44(1), P. 34 - 49
Published: Nov. 14, 2022
Language: Английский
Citations
142
Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)
Published: Oct. 16, 2023
Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.
Language: Английский
Citations
69
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: April 21, 2023
As traditional strategies for cancer treatment, some chemotherapy agents, such as doxorubicin, oxaliplatin, cyclophosphamide, bortezomib, and paclitaxel exert their anti-tumor effects by inducing immunogenic cell death (ICD) of tumor cells. ICD induces immunity through release of, or exposure to, damage-related molecular patterns (DAMPs), including high mobility group box 1 (HMGB1), calreticulin, adenosine triphosphate, heat shock proteins. This leads to activation tumor-specific immune responses, which can act in combination with the direct killing functions drugs on cells further improve curative effects. In this review, we highlight mechanisms underlying ICD, those several chemotherapeutic DAMPs exposed during activate system, well discussing prospects application potential role immunotherapy, aim providing valuable inspiration future development chemoimmunotherapy.
Language: Английский
Citations
60
Artificial Intelligence Chemistry, Journal Year: 2023, Volume and Issue: 1(2), P. 100011 - 100011
Published: Aug. 10, 2023
Adverse drug reactions (ADRs) and drug-induced toxicity are major challenges in discovery, threatening patient safety dramatically increasing healthcare expenditures. Since ADRs not as visible infectious diseases, the potential consequences considerable. Early detection of is an essential indicator a drug's viability profile. The introduction artificial intelligence (AI) machine learning (ML) approaches has resulted paradigm shift field early ADR detection. application these modern computational methods allows for rapid, thorough, precise prediction probable even before practical synthesis well preclinical clinical trials, resulting more efficient safer medications with lesser chance withdrawal. This present review offers in-depth examination role AI ML toxicity, incorporating wide range methodologies ranging from data mining to deep followed by list important databases, modeling algorithms, software that could be used predicting series toxicity. also provides complete reference what been performed might accomplished ML-based identification By shedding light on capabilities technologies, it highlights their enormous revolutionizing discovery improving safety.
Language: Английский
Citations
55
Cardiovascular Pathology, Journal Year: 2024, Volume and Issue: 73, P. 107683 - 107683
Published: Aug. 6, 2024
Language: Английский
Citations
19
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 883 - 894
Published: Jan. 1, 2025
Chronic liver disease ranks as the 11th leading cause of death worldwide, while hepatocellular carcinoma (HCC) is fourth cancer-related mortality, representing a substantial risk to public health. Over past few decades, global landscape chronic diseases, including hepatitis, metabolic dysfunction-associated steatotic (MASLD), fibrosis, and HCC, has undergone changes. Copper, vital trace element for human health, predominantly regulated by liver. Both copper deficiency excess can lead cellular damage dysfunction. Copper deposition genetic process copper-dependent cell associated with mitochondrial respiration, which cardiovascular IBD. However, roles overload cuproptosis in remain largely underexplored. This article examines recent studies on metabolism disease, investigating potential targeting ions therapeutic approach. The objective offer insights guidance future investigations this developing field study.
Language: Английский
Citations
3
Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 4, 2025
Abstract Doxorubicin, a representative drug of the anthracycline class, is widely used in cancer treatment. However, Doxorubicin-induced cardiotoxicity (DIC) presents significant challenge its clinical application. Mitochondrial dysfunction plays central role DIC, primarily through disrupting mitochondrial dynamics. This study aimed to investigate impact Rnd3 (a Rho family GTPase 3) on with focus Cardiomyocyte-specific transgenic mice (Rnd3-Tg) and LSP/LSP (N-Tg) were established for vivo experiments, adenoviruses harboring (Ad-Rnd3) or negative control (Ad-Control) injected myocardium vitro experiments. The DIC model was using wild-type, N-Tg, Rnd3-Tg mice, subsequent intraperitoneal injection Dox 4 weeks. molecular mechanism explored RNA sequencing, immunofluorescence staining, co-immunoprecipitation assay, protein-protein docking. administration induced injury cardiac dysfunction, which ameliorated by overexpression. Further, augmentation expression mitigated fragmentation mediated dynamin-related protein 1 (Drp1), thereby ameliorating PANoptosis (pyroptosis, apoptosis, necroptosis) response Dox. Mechanically, interaction between Rho-associated kinase (Rock1) may impede Rock1-induced Drp1 phosphorylation at Ser616, thus inhibiting fission dysfunction. Interestingly, Rock1 knockdown nullified effects cardiomyocytes PANoptosis, as well Dox-induced remodeling elicited Rnd3. enhances resilience against stabilizing dynamics reducing PANoptosis. Our findings suggest that Rnd3/Rock1/Drp1 signaling pathway represents novel target mitigating modulating could be strategic approach safeguarding function patients undergoing
Language: Английский
Citations
2
Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)
Published: July 26, 2023
Abstract Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment. Unexpectedly, its cardiotoxic side effects have proven to be formidable obstacle. Numerous studies are currently devoted elucidating the pathological mechanisms underlying doxorubicin-induced cardiotoxicity. Nrf2 has always played crucial role in oxidative stress, but numerous demonstrated that it also plays vital part like cell death and inflammation. on associated with cardiotoxicity demonstrate this. Several drugs, natural synthetic compounds, as well small molecule RNAs been prevent by activating Nrf2. Consequently, this study emphasizes introduction of Nrf2, discusses cardiotoxicity, concludes summary therapeutic modalities targeting ameliorate highlighting potential value
Language: Английский
Citations
42
Food & Function, Journal Year: 2023, Volume and Issue: 14(8), P. 3849 - 3862
Published: Jan. 1, 2023
Doxorubicin (DOX) is used extensively in anticancer therapy, but its clinical application limited due to cardiotoxicity. Carnosic acid (CA) a bioactive compound found rosemary. It has been shown reduce inflammation and reactive oxygen species. The purpose of this study was investigate the potential cardioprotective effects CA response DOX-induced Here, C57BL/6 mice were administered an intraperitoneal injection DOX (5 mg kg-1, ip) once week for three consecutive weeks treated with (40 ig) three-week experimental period. For vitro study, neonatal rat ventricular cardiomyocytes validate protective (20 μM) markedly suppressed oxidative stress, apoptosis, pyroptosis responses mouse hearts, eventually improving cardiac function. showed antioxidant effect by activating nuclear factor erythroid 2-related (Nrf2) downstream heme oxygenase-1 (HO-1); also reduced stress lowering MDA lipid ROS levels raising SOD GSH-px levels. Additionally, treatment significantly increased Bcl-2 inhibited Bax Caspase-3 cleavage Moreover, NOD-like receptor protein 3 (NLRP3) pathway mitigate pyroptosis, as evidenced lowered caspase1, interleukin-18, interleukin-1β. Consistently, transfection Nrf2-siRNA eliminated on cardiomyocytes. Altogether, our findings demonstrated that NLRP3 inflammasomes via Nrf2-related cytoprotective system protected heart from damage, implying use could be therapeutic strategy prevention DOX-associated myocardiopathy.
Language: Английский
Citations
28
Redox Biology, Journal Year: 2023, Volume and Issue: 60, P. 102625 - 102625
Published: Feb. 4, 2023
Cardiotoxicity is a frequent and often lethal complication of doxorubicin (DOX)-based chemotherapy. Here, we report that hydropersulfides (RSSH) are the most effective reactive sulfur species in conferring protection against DOX-induced toxicity H9c2 cardiac cells. Mechanistically, RSSH supplementation alleviates DOX-evoked surge oxygen (ROS), activating nuclear factor erythroid 2-related 2 (Nrf2)-dependent pathways, thus boosting endogenous antioxidant defenses. Simultaneously, turns on peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), master regulator mitochondrial function, while decreasing caspase-3 activity to inhibit apoptosis. Of note, find potentiate anticancer DOX effects three different cancer cell lines, with evidence suggests this occurs via induction reductive stress. Indeed, cells already exhibit much higher basal hydrogen sulfide (H
Language: Английский
Citations
27