Advanced Therapeutics,
Journal Year:
2023,
Volume and Issue:
6(12)
Published: Sept. 8, 2023
Abstract
Ever
since
the
first
application
of
mesenchymal
stem
cell
(MSC)
transplantation
treating
human
hematologic
malignancies
in
1995,
MSC‐based
treatments
have
demonstrated
great
therapeutic
potential
clinical
settings.
However,
only
a
few
therapy
products
been
clinically
approved.
Accumulating
evidence
suggests
that
beneficial
effects
MSCs
are
mainly
attributed
to
release
paracrine
factors
or
extracellular
vesicles
(EVs)
rather
than
their
mesodermal
differentiation
potential.
Therefore,
MSC‐derived
EVs
(MSC‐EVs),
such
as
exosomes
and
microvesicles,
merged
promising
alternatives
traditional
cell‐based
therapeutics
practice.
They
offer
several
advantages
better
safety,
lower
immunogenicity,
protection
cargoes
from
degradation,
ability
overcome
biological
barriers.
Moreover,
there
multiple
studies
exploring
MSC‐EVs
for
various
diseases,
including
orthopedic
disorders.
is
no
definitive
“cure”
conditions
osteoporosis
other
bone
disorders,
but
displayed
significant
these
ailments.
objective
this
study
conduct
systematic
review
current
knowledge
related
emphasize
defects,
osteoarthritis,
osteoporosis,
intervertebral
disc
degeneration,
osteosarcoma,
osteoradionecrosis.
Stem Cells International,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Background
.
Stem
cell‐derived
extracellular
vesicles
(SCEVs)
have
emerged
as
a
potential
therapy
for
hemorrhagic
stroke.
However,
their
effects
are
not
fully
understood.
The
aim
of
this
study
was
to
comprehensively
evaluate
the
SCEVs
in
rodent
models
stroke,
including
subarachnoid
hemorrhage
(SAH)
and
intracerebral
(ICH).
Materials
Methods
We
conducted
comprehensive
search
PubMed,
EMBASE,
Web
Science
until
May
2023
identify
studies
investigating
ICH.
functional
outcomes
were
assessed
using
neurobehavioral
scores.
Standardized
mean
differences
(SMDs)
confidence
intervals
(CIs)
calculated
random‐effects
model.
Three
authors
independently
screened
articles
based
on
inclusion
exclusion
criteria.
All
statistical
analyses
performed
Revman
5.3
Stata
17.0.
Results
Twelve
published
between
2018
met
Our
results
showed
that
improved
scores
SAH
model
(SMD
=
−3.49,
95%
CI:
−4.23
−2.75;
p
<
0.001).
Additionally,
chronic
ICH
2.38,
0.36–4.40;
0.02)
but
did
significant
impact
acute
subacute
phases.
Significant
heterogeneity
observed
among
studies,
further
stratification
sensitivity
failed
source
heterogeneity.
Conclusions
findings
suggest
may
improve
neurofunctional
behavior
after
stroke
provide
important
insights
into
design
preclinical
trials.
Bulletin Of Medical And Biological Research,
Journal Year:
2024,
Volume and Issue:
6(2), P. 16 - 24
Published: May 3, 2024
A
new
direction
in
cell
therapy
for
ischemic
stroke
has
been
the
use
of
mesenchymal
stromal
cells,
which
have
shown
a
positive
impact
on
functional
changes
central
nervous
system
due
to
their
neuroprotective
effects,
reduction
ischemia-reperfusion-induced
injury,
inhibition
apoptosis,
and
restoration
motor
function.
This
study
aimed
investigate
effect
cells
different
origins,
lysate,
citicoline
state
rats
with
experimental
brain
ischemia-reperfusion.
The
considered
derived
from
human
umbilical
cord
Wharton’s
jelly,
rat
adipose
tissue,
embryonic
fibroblasts,
as
well
lysate
emotional
behavioural
responses
sexually
mature
Wistar
(3-4
months)
weighing
160-190
g.
were
studied
using
open
field
test
7th
14th
days
experiment;
following
acts
recorded:
ambulation
(locomotion),
climbing,
rearing,
grooming.
significance
differences
was
determined
non-parametric
Mann-Whitney
U
test.
It
established
that
after
ischemia-reperfusion,
animals
control
pathology
showed
significant
decrease
duration
episodes
peripheral
squares,
vertical
locomotor
activity,
exploratory
activity
compared
sham-operated
group.
In
received
transplanted
jelly
increase
horizontal
observed
other
types
stem
control.
Intravenous
administration
fibroblasts
increased
animals.
least
adaptive
ischemia-reperfusion
registered
groups
lysate.
practical
lies
search
most
effective
class
properties
creation
an
injectable
drug
intravenous
transplantation
treatment
patients
acute
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(10), P. e0312298 - e0312298
Published: Oct. 21, 2024
Rehabilitation
is
the
only
current
intervention
that
improves
sensorimotor
function
in
ischemic
stroke
patients,
similar
to
task-specific
intensive
training
animal
models
of
stroke.
Bone
marrow
mesenchymal
stem
cells
(BM-MSCs)-derived
extracellular
vesicles
(EVs)
are
promising
restoring
brain
damage
and
models.
Additionally,
non-invasive
intranasal
route
allows
EVs
reach
target
specific
regions.
Yet
unclear
how
handling
might
enhance
recovery
or
influence
other
therapies
such
as
after
We
used
transient
middle
cerebral
artery
occlusion
(MCAO)
model
rats
assess
alone,
form
behavioral
tests,
combination
with
an
treatment
restored
neurological
damage.
Handled
were
exposed
a
battery
including
modified
Neurological
Severity
Score
(mNSS),
beam
balance,
corner,
grid
walking,
forelimb
placement,
cylinder
together
Magnetic
Resonance
Imaging
(MRI)
at
2,
7,
14,
21,
28
days
post-stroke
(dps).
MCAO
also
multidose
single
dose
EVs.
Non-handled
evaluated
by
mNSS
MRI
28,
56
dps
treated
Our
results
showed
animals
necessary
for
work
tested
frequency,
cumulative
further
recovered
during
handling.
These
show
importance
rehabilitation
treatments
EVs,
highlight
extensive
testing
functional
Cellular and Molecular Neurobiology,
Journal Year:
2022,
Volume and Issue:
43(5), P. 1975 - 1988
Published: Sept. 9, 2022
The
success
rate
of
regenerative
medicine
largely
depends
on
the
type
stem
cells
applied
in
such
procedures.
Consequently,
to
achieve
needed
level
for
clinical
standardization,
we
need
investigate
viability
accessible
sources
with
sufficient
quantity
cells.
Since
oral
region
partly
originates
from
neural
crest,
which
naturally
develops
niche
decreased
levels
oxygen,
main
goal
this
work
was
test
if
human
mucosa
(hOMSC)
might
be
used
treat
neurons
damaged
by
anoxia.
Here
show
that
hOMSC
are
more
resistant
anoxia
than
induced
pluripotent
and
they
secrete
BDNF,
GDNF,
VEGF
NGF.
When
were
added
anoxia,
significantly
improved
their
survival.
This
capability
at
least
achieved
through
miR-514A-3p
SHP-2
it
exposed
14
or
28
days.
In
addition,
beneficial
effect
also
confirmed
mice
affected
stroke.
Hence,
have
hOMSC,
a
time-limited
manner,
improve
survival
anoxia-damaged
contribute
recovery
experimental
animals
following
Advanced Therapeutics,
Journal Year:
2023,
Volume and Issue:
6(12)
Published: Sept. 8, 2023
Abstract
Ever
since
the
first
application
of
mesenchymal
stem
cell
(MSC)
transplantation
treating
human
hematologic
malignancies
in
1995,
MSC‐based
treatments
have
demonstrated
great
therapeutic
potential
clinical
settings.
However,
only
a
few
therapy
products
been
clinically
approved.
Accumulating
evidence
suggests
that
beneficial
effects
MSCs
are
mainly
attributed
to
release
paracrine
factors
or
extracellular
vesicles
(EVs)
rather
than
their
mesodermal
differentiation
potential.
Therefore,
MSC‐derived
EVs
(MSC‐EVs),
such
as
exosomes
and
microvesicles,
merged
promising
alternatives
traditional
cell‐based
therapeutics
practice.
They
offer
several
advantages
better
safety,
lower
immunogenicity,
protection
cargoes
from
degradation,
ability
overcome
biological
barriers.
Moreover,
there
multiple
studies
exploring
MSC‐EVs
for
various
diseases,
including
orthopedic
disorders.
is
no
definitive
“cure”
conditions
osteoporosis
other
bone
disorders,
but
displayed
significant
these
ailments.
objective
this
study
conduct
systematic
review
current
knowledge
related
emphasize
defects,
osteoarthritis,
osteoporosis,
intervertebral
disc
degeneration,
osteosarcoma,
osteoradionecrosis.
