Chronobiology International,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 8
Published: Sept. 23, 2024
Circadian
rhythm
disruptions
have
been
implicated
in
numerous
health
issues,
including
cognitive
decline
and
the
exacerbation
of
neurodegenerative
diseases,
like
Alzheimer
disease
(AD).
Brain-derived
neurotrophic
factor
(BDNF),
vital
for
neuronal
plasticity
function,
is
regulated
by
circadian
clock
exerts
protective
effects
against
AD.
Thus,
we
investigated
impact
disorders
(CRDs)
on
impairment
explored
underlying
neurobiological
mechanisms
assessing
BDNF
amyloid-β
(Aβ)
levels.
We
divided
male
C57BL/6
mice
into
three
groups
(
Sleep Medicine Reviews,
Journal Year:
2023,
Volume and Issue:
72, P. 101845 - 101845
Published: Aug. 31, 2023
Watchkeeping
schedules
are
essential
for
maintaining
submarine
operations,
but
come
with
human
risk
factors
including,
disrupted
sleep,
circadian
misalignment,
and
cognitive
deficits.
There
is
now
an
emerging
literature
examining
the
strengths
weaknesses
of
watchkeeping
trialled
in
field
under
simulated
laboratory
conditions.
The
aim
this
scoping
review
was
to
summarise
literature.
A
systematic
search
peer-reviewed
journal
articles
industry
reports
listed
MEDLINE,
PsychINFO,
PubMed,
Scopus,
Embase
Google
Scholar
undertaken
May
2023
returned
7298
papers.
Following
screening
procedures,
13
studies
were
identified
inclusion.
findings
revealed
that
sleep
sufficiently
preserved
regardless
schedule
(total
time
=
5.46-7.89
h),
misalignment
greater
non-24
h
schedules,
longer
off-watch
periods
associated
better
performance.
Taken
together,
when
comparing
between
present
suggest
4
h-on/8
h-off
8
h-on/16
may
be
a
good
compromise
balancing
operational
demands.
However,
submarines
complex
challenging
environments
study
there
need
expand
More
research
needed.
Future
should
focus
on
performance
measures,
such
as
problem-solving,
prioritisation
executive
decision-making
address
shortcomings,
examination
countermeasures
assist
adaptation
either
initiated
pre-deployment
or
by
modifying
environment
itself
considered.
Frontiers in Cell and Developmental Biology,
Journal Year:
2022,
Volume and Issue:
10
Published: April 12, 2022
Distinct
from
Earth’s
environment,
space
environmental
factors
mainly
include
radiation,
microgravity,
hypomagnetic
field,
and
disrupted
light/dark
cycles
that
cause
physiological
changes
in
astronauts.
Numerous
studies
have
demonstrated
can
lead
to
muscle
atrophy,
bone
loss,
carcinogenesis,
immune
disorders,
vascular
function
cognitive
impairment.
Most
current
ground-based
focused
on
single
factor
biological
effects.
To
promote
manned
exploration,
a
better
understanding
of
the
effects
spaceflight
environment
is
necessary.
This
paper
summarizes
latest
research
progress
combined
double
or
multiple
mammalian
cells,
discusses
their
possible
molecular
mechanisms,
with
hope
providing
scientific
theoretical
basis
develop
appropriate
countermeasures
for
Animal Models and Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
7(1), P. 71 - 76
Published: Feb. 1, 2024
Abstract
The
rodent
running‐wheel
recording
apparatus
is
a
reliable
approach
for
studying
circadian
rhythm.
This
study
demonstrated
how
to
construct
simple
and
intelligent
system.
running
wheel
was
attached
the
cage's
base,
whereas
Hall
sensor
cover.
Then,
RJ25
adaptor
relayed
signal
main
control
board.
Finally,
board
connected
USB
port
of
computer
with
connection.
Data
were
collected
using
online‐accessible,
self‐created
software
Magturning.
Through
Magturning,
generated
data
saved
exported
in
real
time.
Afterward,
device
validated
by
collecting
on
locomotor
activities
mice
under
different
light
conditions.
In
conclusion,
this
new
can
record
activity
rodents.
Our
appropriate
interdisciplinary
investigations
related
biological
clock
research.
Biomedical and Biotechnology Research Journal (BBRJ),
Journal Year:
2024,
Volume and Issue:
8(2), P. 160 - 165
Published: April 1, 2024
Abstract
Background:
This
study
investigates
the
impact
of
blue
light-emitting
diode
(LED)
lighting
on
physiological
responses
Wistar
rats.
The
circadian
system
plays
a
vital
role
in
regulating
functions,
allowing
organisms
to
anticipate
and
adapt
environmental
rhythms.
synchronization
endogenous
clocks
with
external
cues,
such
as
light-dark
cycles,
is
essential
for
optimal
performance.
However,
emerging
technologies,
like
LED
lighting,
present
new
challenges
rhythms,
highlighting
need
continued
research
this
area.
Methods:
study,
approved
by
Animal
Ethics
Committee,
involved
total
12
male
rats,
which
were
divided
into
two
groups:
Control
group
light
(BL)
treated
group,
each
consisting
six
BL
model
was
established
subjecting
rats
h
exposure
daily
period
3
months.
Half
sacrificed
at
end
period,
while
remaining
transitioned
normal
(NL)
conditions
another
months
before
being
euthanized.
Blood
tissue
samples
collected
analysis,
including
measurements
body
weight,
blood
glucose,
insulin,
melatonin,
lipid
profile,
well
messenger
RNA
expression
reverse
transcription-polymerase
chain
reaction
global
DNA
methylation
enzyme-linked
immunosorbent
assay.
Results:
found
that
led
higher
monthly
increase
elevated
glucose
levels,
decreased
insulin
melatonin
levels
compared
controls.
also
caused
decrease
cholesterol,
triglycerides,
high-density
lipoprotein,
low-density
lipoprotein.
Gene
analysis
revealed
downregulation
Period1,
Cryptochrome1,
brain
muscle
arnt-like
protein
1
(Bmal1)
hypothalamus,
significant
upregulation
upon
returning
NL
conditions.
induced
hypermethylation
sequences,
partially
reverted
after
Conclusion:
Our
reveals
broad
BL/artificial
contributing
incidence
obesity
metabolic
disorders.
With
rise
blue-rich
more
needed
understand
its
long-term
effects
health.
contributes
deeper
understanding
intricate
relationship
between
health,
emphasizing
importance
informed
decisions
regarding
technologies
mitigate
potential
health
risks.
Chronobiology International,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 8
Published: Sept. 23, 2024
Circadian
rhythm
disruptions
have
been
implicated
in
numerous
health
issues,
including
cognitive
decline
and
the
exacerbation
of
neurodegenerative
diseases,
like
Alzheimer
disease
(AD).
Brain-derived
neurotrophic
factor
(BDNF),
vital
for
neuronal
plasticity
function,
is
regulated
by
circadian
clock
exerts
protective
effects
against
AD.
Thus,
we
investigated
impact
disorders
(CRDs)
on
impairment
explored
underlying
neurobiological
mechanisms
assessing
BDNF
amyloid-β
(Aβ)
levels.
We
divided
male
C57BL/6
mice
into
three
groups
(
