Introduction.
Schizophrenia
is
a
complex
mental
disorder
with
heterogeneous
symptoms,
including
psychotic,
negative,
cognitive,
affective,
and
psychomotor
symptoms.
Although
the
pathogenesis
of
schizophrenia
mainly
associated
neurotransmitter
imbalance,
recent
studies
have
suggested
importance
neuroinflammation
in
this
disease.
Objective.
To
study
involvement
prognostic
assessment
potential
anti-inflammatory
effect
antipsychotic
medications.
Discussion.
Current
data
indicate
significant
role
development
course
schizophrenia.
At
initial
stages
its
development,
number
lymphocytes
level
some
proinflammatory
cytokines
(IL-1,
IL-6,
TNF-α,
IL-1β)
increase,
which
can
be
decreased
by
therapy.
Studies
involving
experimental
models
maternal
immune
activation
(MIA)
obtained
immunohistochemical
PET
confirm
an
abnormal
microglia,
indicating
innate
cells.
Adaptive
response
cells
also
play
Thus,
increased
Th17
increase
production
cytokines,
correlating
disease
severity,
were
revealed.
The
neurotransmitters
modulating
immune-inflammatory
discussed.
Available
suggest
that
participation
dopamine
mediated
immunomodulatory
effect.
indicated
clinical
effectiveness
treatment
On
other
hand,
antipsychotics
has
been
established,
which,
at
least
part,
may
mediate
their
Conclusions.
Given
pathogenesis,
further
into
both
properties
effects
drugs
are
promising
order
to
optimize
BMC Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 25, 2025
Sensory
impairments
(SI),
including
vision
(VI),
hearing
(HI),
and
dual
sensory
(DSI),
are
prevalent
with
aging,
but
their
impact
on
disease
risk
remains
unclear.
This
study
investigates
the
epidemiological
genetic
associations
between
SIs
10
chronic
categories
multimorbidity.
Using
CHARLS
study,
participants
were
classified
by
self-reported
VI/HI/DSI
status
in
2011
2013
into
groups:
"new
onset,
remission,
persistent,
no
SI."
Their
incidence
was
tracked
until
2018
sub-cohorts
respectively.
Mendelian
randomization
(MR)
analyses
used
instruments
from
UK
Biobank
GWAS
data
88,250/504,307
individuals
for
vision/hearing
loss,
outcome
datasets
consortia
FinnGen,
DIAMANTE,
CKDGen,
PGC,
Catalog,
International
Parkinson's
Disease
Genomics
Consortium.
The
cohort
revealed
that
persistent
HI
significantly
increased
of
heart
(P
<
0.001,
HR
1.63,
95%
CI
1.31–2.03),
stroke
0.004,
1.59,
1.16–2.18),
lung
0.002,
1.53,
1.17–1.99),
emotional,
nervous,
or
psychiatric
problems
0.016,
2.03,
1.14–3.60).
Persistent
VI
associated
diabetes
high
blood
sugar
(DM/Hglu)
0.012,
1.11–2.38)
0.042,
1.02–2.31).
MR
confirmed
these
strong
suggestive
associations,
indicating
cardiovascular
cerebrovascular
events
61–170%,
bronchitis
160%,
schizophrenia
36%.
In
addition,
raised
hyperglycemia
2–4%
function
decline.
Additionally,
studies
early
DSI
multiple
diseases,
while
identified
links
hepatic
failure,
Parkinson's,
Alzheimer's
disease,
hypertension,
kidney
renal
failure.
provides
evidence
perspectives
demonstrates
exposure
to
HI/VI/DSI
increases
developing
diseases.
These
findings
underscore
need
continuous
monitoring
timely
intervention
SI
manage
risks
aging
populations.
Current Opinion in Psychiatry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 13, 2025
Purpose
of
review
Obesity
and
related
metabolic
disorders
are
extremely
common
in
psychiatric
patients,
particularly
those
with
schizophrenia.
Elucidating
this
link's
neurobiology
may
inform
clinicians
researchers
rational
therapeutic
approaches
necessary
to
optimize
clinical
outcomes.
Recent
findings
Current
literature
highlights
the
pivotal
role
inflammation-oxidative
stress-insulin
resistance
loop
pathophysiology
both
neuropsychiatric
disorders.
The
concept
‘diabetophrenia’
is
put
forward
highlight
overlapping
neurobiological
mechanisms
underlying
dysfunction
schizophrenia
symptoms.
Innovative
treatments,
including
combination
xanomeline
trospium
incretin-based
medicines,
demonstrate
encouraging
potential
addressing
such
complex
health
challenges.
Summary
nuanced
dynamics
chronic
inflammation
symptomatology
underscore
significance
mental
factors
a
cohesive
fashion
while
considering
unique
psychosocial
contexts,
dietary
preferences,
lifestyle
choices.
A
multidisciplinary
strategy
essential
for
incorporating
counseling,
interventions,
behavioral
therapies,
pharmacotherapy
into
management
ensuing
enhanced
collaboration
among
healthcare
professionals
render
obsolete
prevailing
siloed
conceptualizations
disorders,
opening
new
vistas
generating
synergistic
insights
mind-body
systems
leading
improved
quality
life
patients
other
conditions.
Introduction.
Schizophrenia
is
a
complex
mental
disorder
with
heterogeneous
symptoms,
including
psychotic,
negative,
cognitive,
affective,
and
psychomotor
symptoms.
Although
the
pathogenesis
of
schizophrenia
mainly
associated
neurotransmitter
imbalance,
recent
studies
have
suggested
importance
neuroinflammation
in
this
disease.
Objective.
To
study
involvement
prognostic
assessment
potential
anti-inflammatory
effect
antipsychotic
medications.
Discussion.
Current
data
indicate
significant
role
development
course
schizophrenia.
At
initial
stages
its
development,
number
lymphocytes
level
some
proinflammatory
cytokines
(IL-1,
IL-6,
TNF-α,
IL-1β)
increase,
which
can
be
decreased
by
therapy.
Studies
involving
experimental
models
maternal
immune
activation
(MIA)
obtained
immunohistochemical
PET
confirm
an
abnormal
microglia,
indicating
innate
cells.
Adaptive
response
cells
also
play
Thus,
increased
Th17
increase
production
cytokines,
correlating
disease
severity,
were
revealed.
The
neurotransmitters
modulating
immune-inflammatory
discussed.
Available
suggest
that
participation
dopamine
mediated
immunomodulatory
effect.
indicated
clinical
effectiveness
treatment
On
other
hand,
antipsychotics
has
been
established,
which,
at
least
part,
may
mediate
their
Conclusions.
Given
pathogenesis,
further
into
both
properties
effects
drugs
are
promising
order
to
optimize
