IMPACTO DA ASSOCIAÇÃO ENTRE VITAMINA D E DENSIDADE MAMÁRIA NA REDUÇÃO DO RISCO DE CÂNCER DE MAMA DOI Creative Commons
Maria Stefania Nóbrega Batista, Lara Moreira Mendes Carneiro

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, Journal Year: 2022, Volume and Issue: 3(11), P. e3112155 - e3112155

Published: Nov. 7, 2022

Considerando o aumento do número de casos câncer, em especial câncer mama, fica evidente a necessidade identificar fatores risco modificáveis da doença. Estudos relataram uma associação inversa entre status vitamina D e mama através redução densidade mamográfica, um conhecido fator câncer. O objetivo deste trabalho é definir se há mamográfica esta pode reduzir mama. Foi realizada revisão integrativa literatura, com os descritores Ciências Saúde “Vitamin D” AND “Mammographic Density” nas seguintes bibliotecas virtuais: MEDLINE, PUBMED, LILACS SCIELO. Os estudos que avaliaram relação têm achados heterogêneos; uns mostram pacientes níveis séricos normais D, outros, não. Contudo, dosagem insuficiente não deve ser desconsiderada, especialmente devido seu efeito comprovadamente importante na formação óssea homeostase cálcio.

The Impact of Vitamin D and Its Dietary Supplementation in Breast Cancer Prevention: An Integrative Review DOI Open Access
Antía Torres,

Carla Cameselle,

Paz Otero

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(5), P. 573 - 573

Published: Feb. 20, 2024

Vitamin D deficiency is currently a significant public health issue closely linked to numerous diseases, such as breast cancer. This study aims determine the estimated optimal serum levels of vitamin have protective effect against cancer, in addition exploring biological mechanisms and risk factors involved. A literature search articles published last 5 years was conducted, simple statistical analyses using mean standard deviation were performed calculate average concentration from different available studies. It has been observed that ≥ 40.26 ng/mL ± 14.19 could exert Additionally, various mechanisms, those related immune system, like diet implicated this relationship elucidated. Consequently, it can be concluded proper may dietary supplementation an appropriate procedure achieve these concentrations.

Language: Английский

Citations

9
Regulation of inflammatory response by LINC00346 via miR-25-3p-mediated modulation of the PTEN/PI3K/AKT/NF-κB pathway DOI
Min-Ji Kim, Su‐Geun Lim, Dong‐Hyung Cho

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 709, P. 149828 - 149828

Published: March 25, 2024

Language: Английский

Citations

7
Exploring Vitamin D Synthesis and Function in Cardiovascular Health: A Narrative Review DOI Creative Commons
Gilda Aiello, Mauro Lombardo, Sara Baldelli

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(11), P. 4339 - 4339

Published: May 21, 2024

Vitamin D plays a crucial role in the human body, influencing wide range of physiological processes from bone health to immune function. The complex biochemical pathways involved synthesis, metabolism, and action are explored, emphasizing its importance nutrition food technology. This review also investigates regulatory mechanisms that control metabolism systemic effects on calcium homeostasis, cell proliferation, differentiation, modulation. D3 regulating blood pressure atherosclerosis onset cardiovascular disorders is discussed. Given science technology, homeostasis investigated, integrating innovative approaches advanced technologies improve through nutrition. Additionally, assesses influence processing levels discusses cutting-edge as strategies mitigate loss during processing. comprehensive exploration aims our understanding relevance science, contributing development new for fortification promotion optimal diet.

Language: Английский

Citations

6
Exploring the Potential of Dietary Phytochemicals in Cancer Prevention: A Comprehensive Review DOI Open Access

Sunny Rathee,

Umesh Kumar Patil, Sanjay Jain

et al.

Journal of Exploratory Research in Pharmacology, Journal Year: 2024, Volume and Issue: 9(1), P. 51 - 64

Published: Feb. 6, 2024

Cancer is a significant global health issue and primary cause of death. Extensive research has led to the development various anticancer medications, driven by an improved knowledge comprehension molecular pathways involved in cancer growth. However, there need for new approaches enhance effectiveness existing therapies. Dietary phytochemicals have gained increasing attention due their potential role tumor prevention. These bioactive compounds derived from plants exhibit wide range beneficial effects on human health, including ability inhibit carcinogenesis promote activities. Examples dietary with promising properties include vitamin D, E, lycopene, fisetin, genistein, epigallocatechin gallate, crocetin, curcumin, cyanidins, gingerol. often exert regulating interconnected associated progression. Some these apoptosis pathway, cyclooxygenase-2 ATP-dependent chromatin remodeling DNA methylation-epigenetic Hedgehog signaling signal transducer activator transcription protein-3 angiogenesis inhibition Wnt pathway. This comprehensive review aims summarize current prevention, highlighting mechanisms action therapeutic applications.

Language: Английский

Citations

5
Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study DOI Open Access
Cosima Zemlin, Laura Altmayer,

Caroline Stuhlert

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1450 - 1450

Published: March 17, 2023

(1) Background: Vitamin D plays an important role in many types of cancer. It was the aim this study to analyze serum 25-hydroxyvitamin (25(OH)D) levels newly diagnosed breast cancer patients, and association with prognostic lifestyle factors. (2) Methods: 110 non-metastatic patients were included prospective observational “BEGYN” at Saarland University Medical Center between September 2019 January 2021. At initiation visit, 25(OH)D measured. Clinicopathological data on prognosis, nutrition, extracted from files obtained using a questionnaire. (3) Results: Median 24 ng/mL (range 5–65 ng/mL), 64.8% being vitamin deficient. higher among that reported use supplements (43 versus 22 ng/mL; p < 0.001), summer compared other seasons (p = 0.03). Patients moderate deficiency less likely have triple negative 0.047). (4) Conclusions: Routinely measured is common needs be detected treated. However, our results do not support hypothesis may main factor for

Language: Английский

Citations

12
Simultaneous determination of 25(OH)D2, 25(OH)D3 and 1α,25(OH)2D3 in human serum by derivatization-liquid chromatography-tandem mass spectrometry DOI
Zengbin Wang, Liping Hao,

Z. X. Meng

et al.

Analytical Biochemistry, Journal Year: 2025, Volume and Issue: 701, P. 115821 - 115821

Published: Feb. 24, 2025

Language: Английский

Citations

0
Investigating Vitamin D3’s anticancer mechanisms in MCF-7 cells: a network pharmacology and omics technology approach DOI

Komal S. Wakle,

Pawan N. Karwa,

Nikhil S. Sakle

et al.

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

Citations

0
PSMA3-AS1: a promising LncRNA as a diagnostic and prognostic biomarker in human cancers DOI
Yunxia Niu, Junqing Meng, Xue Zhao

et al.

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149521 - 149521

Published: April 1, 2025

Language: Английский

Citations

0
Tracing vitamins on the long non-coding lane of the transcriptome: vitamin regulation of LncRNAs DOI Creative Commons
Fatemeh Yazarlou, Fatemeh Alizadeh, Leonard Lipovich

et al.

Genes & Nutrition, Journal Year: 2024, Volume and Issue: 19(1)

Published: March 12, 2024

Abstract A major revelation of genome-scale biological studies in the post-genomic era has been that two-thirds human genes do not encode proteins. The majority non-coding RNA transcripts humans are long (lncRNA) molecules, non-protein-coding regulatory with sizes greater than 500 nucleotides. LncRNAs involved nearly every aspect cellular physiology, playing fundamental roles both normal cells and disease. As result, they functionally linked to multiple diseases, from cancer autoimmune, inflammatory, neurological disorders. Numerous conditions diseases stem gene-environment interactions; this regard, a wealth reports demonstrate intake specific essential nutrients, including vitamins, shapes our transcriptome, corresponding impacts on health. Vitamins command vast array activities, acting as coenzymes, antioxidants, hormones, regulating proliferation coagulation. Emerging evidence suggests vitamins lncRNAs interconnected through several axes. This type interaction is expected, since lncRNA implicated sensing environment eukaryotes, conceptually similar riboswitches other RNAs act molecular sensors prokaryotes. In review, we summarize peer-reviewed literature date reported functional linkages between lncRNAs, an emphasis mammalian models humans, while providing brief overview source, metabolism, function most frequently investigated within context mechanisms, discussing published research findings document connections lncRNAs.

Language: Английский

Citations

3
Lower vitamin D levels and VDR variants are risk factors for breast cancer: an updated meta-analysis DOI
Zhenyu Zhao,

Wenyu Cai,

Jing Xing

et al.

Nucleosides Nucleotides & Nucleic Acids, Journal Year: 2022, Volume and Issue: 42(1), P. 17 - 37

Published: Aug. 9, 2022

Inadequate vitamin D levels and variants have been shown to be associated with breast cancer (BC), however the results are inconsistent. To reach a definitive conclusion present meta-analysis was conducted. When compared healthy controls, BC patients had reduced (standard difference in means = −0.564, p 0.003). The revealed that FokI mutation linked an increased susceptibility (CC vs. TT: OR 1.107, 0.001, CC TC + 1.114, 0.020). There no role of other VDR (BsmI, TaqI, ApaI). diminished increase likelihood developing BC.

Language: Английский

Citations

7