Oncology Reports,
Journal Year:
2024,
Volume and Issue:
53(1)
Published: Nov. 20, 2024
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
a
malignant
neoplasm
that
typically
manifests
with
subtle
clinical
manifestations
in
its
early
stages
and
frequently
eludes
diagnosis
until
the
advanced
phases
of
disease.
The
limited
therapeutic
options
available
for
PDAC
significantly
contribute
to
high
mortality
rate,
highlighting
urgent
need
novel
biomarkers
capable
effectively
identifying
facilitating
precise
diagnosis.
pivotal
role
cellular
exosomes
both
pathogenesis
interventions
has
been
underscored.
Furthermore,
researchers
have
acknowledged
potential
as
targeted
drug
carriers
against
regulatory
cells
treating
PDAC.
present
article
aims
provide
comprehensive
review
encompassing
recent
advancements
utilizing
elucidating
mechanisms
underlying
disease
development,
patterns
metastasis,
diagnostic
techniques
treatment
strategies
associated
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2022,
Volume and Issue:
10
Published: Oct. 20, 2022
Gastrointestinal
tumours
are
the
most
common
solid
tumours,
with
a
poor
prognosis
and
remain
major
challenge
in
cancer
treatment.
Mesenchymal
stem
cells
(MSC)
multipotent
stromal
potential
to
differentiate
into
multiple
cell
types.
Several
studies
have
shown
that
MSC-derived
exosomes
become
essential
regulators
of
intercellular
communication
variety
physiological
pathological
processes.
Notably,
support
or
inhibit
tumour
progression
different
cancers
through
delivery
proteins,
RNA,
DNA,
bioactive
lipids.
Herein,
we
summarise
current
advances
research,
particular
reference
their
role
gastrointestinal
development.
expected
be
novel
strategy
for
treatment
cancers.
Cell Cycle,
Journal Year:
2023,
Volume and Issue:
22(12), P. 1514 - 1527
Published: May 28, 2023
Background
Long
non-coding
RNAs
(lncRNAs)
have
been
proved
to
play
a
vital
role
in
pancreatic
cancer
(PC).
However,
the
of
lncRNA
FAM83A-AS1
PC
remains
unclear.
In
this
study,
we
explored
biological
function
and
underlying
mechanism
cells.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(10), P. 2460 - 2460
Published: Oct. 13, 2023
Hepatocellular
carcinoma
(HCC)
stands
as
a
significant
contributor
to
global
cancer-related
mortality.
Chronic
inflammation,
often
arising
from
diverse
sources
such
viral
hepatitis,
alcohol
misuse,
nonalcoholic
fatty
liver
disease
(NAFLD),
and
steatohepatitis
(NASH),
profoundly
influences
HCC
development.
Within
this
context,
the
interplay
of
extracellular
vesicles
(EVs)
gains
prominence.
EVs,
encompassing
exosomes
microvesicles,
mediate
cell-to-cell
communication
cargo
transfer,
impacting
various
biological
processes,
including
inflammation
cancer
progression.
Toll-like
receptor
4
(TLR4),
key
sentinel
innate
immune
system,
recognizes
both
pathogen-associated
molecular
patterns
(PAMPs)
damage-associated
(DAMPs),
thereby
triggering
signaling
cascades
pro-inflammatory
cytokine
release.
The
intricate
involvement
TLR4
pathway
in
chronic
pathogenesis
is
discussed
study.
Moreover,
we
delve
into
therapeutic
potential
modulating
using
EVs
novel
agents
for
HCC.
This
review
underscores
multifaceted
role
context
proposes
innovative
avenues
targeted
interventions
against
formidable
disease.
International Journal of Genomics,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 53
Published: Oct. 10, 2022
Ischemic
stroke
(IS)
is
one
of
the
leading
causes
disability
and
mortality
worldwide.
This
study
aims
to
find
crucial
exosomal
miRNAs
associated
with
IS
by
using
bioinformatics
methods,
reveal
potential
biomarkers
for
IS,
investigate
association
between
identified
biomarker
immune
cell
pattern
in
peripheral
blood
patients.
In
this
study,
3
up-regulated
(hsa-miR-15b-5p,
hsa-miR-184,
hsa-miR-16-5p)
serum
exosomes
patients
healthy
controls
from
GEO
database
(GSE199942)
25
down-regulated
genes
mononuclear
cells
GSE22255
were
obtained
help
R
software.
GO
annotation
KEGG
pathway
enrichment
analysis
showed
that
coenzyme
metabolic
process
mainly
enriched
N-glycan
biosynthesis
pathway.
Furthermore,
we
performed
LASSO
algorithm
narrow
down
above
intersected
genes,
8
key
which
had
a
good
diagnostic
value
discriminating
analyzed
ROC
curve.
CIBERSORT
indicated
abundance
M0
macrophages
resting
mast
was
significantly
lower
than
control
group.
The
spearman
correlation
STT3A
negatively
correlated
proportion
follicular
helper
T
cells,
activated
NK
dendritic
cells.
Finally,
GSE117064
has-miR-16-5p
more
advantageous
diagnosing
stroke.
conclusion,
hsa-miR-15b-5p,
hsa-miR-16-5p
are
as
specific
related
These
may
provide
new
targets
early
identification
IS.
Extracellular Vesicles and Circulating Nucleic Acids,
Journal Year:
2024,
Volume and Issue:
5(2), P. 180 - 200
Published: May 9, 2024
Pancreatic
cancer
is
a
highly
lethal
and
metastatic
malignancy,
mainly
because
it
often
remains
undetected
until
advanced
stages
due
to
the
limitations
of
current
diagnostic
methods,
rendering
currently
available
therapies
ineffective.
Therefore,
imperative
identify
useful
biomarkers
for
early
diagnosis
new
therapeutic
targets
pancreatic
cancer.
Recently,
extracellular
vesicles
have
emerged
as
promising
prognosis
Given
their
presence
in
various
bodily
fluids,
offer
non-invasive
approach
through
liquid
biopsy
detect
monitor
progression.
In
this
review,
we
comprehensively
examine
multifaceted
roles
progression
cancer,
while
also
exploring
potential
diagnostic,
prognostic,
context
Oncology Reports,
Journal Year:
2024,
Volume and Issue:
53(1)
Published: Nov. 20, 2024
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
a
malignant
neoplasm
that
typically
manifests
with
subtle
clinical
manifestations
in
its
early
stages
and
frequently
eludes
diagnosis
until
the
advanced
phases
of
disease.
The
limited
therapeutic
options
available
for
PDAC
significantly
contribute
to
high
mortality
rate,
highlighting
urgent
need
novel
biomarkers
capable
effectively
identifying
facilitating
precise
diagnosis.
pivotal
role
cellular
exosomes
both
pathogenesis
interventions
has
been
underscored.
Furthermore,
researchers
have
acknowledged
potential
as
targeted
drug
carriers
against
regulatory
cells
treating
PDAC.
present
article
aims
provide
comprehensive
review
encompassing
recent
advancements
utilizing
elucidating
mechanisms
underlying
disease
development,
patterns
metastasis,
diagnostic
techniques
treatment
strategies
associated
