International Journal of Drug Delivery Technology,
Journal Year:
2024,
Volume and Issue:
14(04), P. 1239 - 1247
Published: Dec. 24, 2024
The
press
coating
approach
has
been
employed
in
the
current
study;
this
system
involves
compressing
directly
of
both
core
as
well
coat.
procedure
is
same:
first,
we
make
tablet
containing
drug,
diluent,
binder,
Crospovidone
superdisintegrant
for
burst
release
after
lag
time,
glidant,
and
lubricant
an
8mm
die.
After
that,
get
Eudragit
S
100
polymer
different
ratios
divide
it
into
two
equal
parts,
subsequently
lower
half
inserted
a
cavity
10mm
die
followed
by
placed
middle,
other
portion
that
comprises
coat
filled
cavity.
Powder's
assessment
parameters
were
judged
to
be
within
appropriate
range.
Overall,
evaluation
results
press-coated
tablets
passed
acceptable
parameters.
Optimized
batch
F7
shows
99.07%
drug
release.
batches
are
further
evaluated
tests
like
FTIR,
DSC,
Stability
study
per
standard
ICH
guidelines.
From
all
result
conclude
concentration
increases
%
also
time.
acts
good
time
only
at
pH
7
means
colon
target
was
done
hence
successfully
pulsatile
delivery
performed.
Cells,
Journal Year:
2022,
Volume and Issue:
11(22), P. 3698 - 3698
Published: Nov. 21, 2022
Interleukin
6
(IL-6)
belongs
to
a
broad
class
of
cytokines
involved
in
the
regulation
various
homeostatic
and
pathological
processes.
These
activities
range
from
regulating
embryonic
development,
wound
healing
ageing,
inflammation,
immunity,
including
COVID-19.
In
this
review,
we
summarise
role
IL-6
signalling
pathways
cancer
biology,
with
particular
emphasis
on
cell
invasiveness
metastasis
formation.
Targeting
principal
components
(e.g.,
IL-6Rs,
gp130,
STAT3,
NF-κB)
is
an
intensively
studied
approach
preclinical
research.
It
significant
translational
potential;
numerous
studies
strongly
imply
remarkable
potential
inhibitors,
especially
suppression.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(15)
Published: April 15, 2024
Abstract
This
review
article
aims
to
significantly
advance
the
scientific
community's
efforts
develop
effective
nucleoside‐based
drugs
for
treating
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2
)
and
other
emerging
infectious
diseases.
study
concentrates
on
main
viral
protease
(Mpro)
explores
compounds
as
potential
therapeutic
agents.
investigation
investigated
impact
of
acylation‐induced
modifications
nucleoside
hydroxyl
group
subsequent
properties.
Nucleoside
analogs,
which
are
recognized
their
diverse
biochemical
properties,
were
synthesized
rigorously
screened
evaluate
antimicrobial
efficacy.
In
domain
pharmaceutical
research,
computational
pharmacokinetics
has
emerged
a
critical
tool,
especially
in
pursuit
analogs
therapeutics.
silico
methods
aid
predicting
pharmacokinetic
traits,
interactions
with
crucial
enzymes,
stability
these
biological
environments,
thereby
streamlining
drug
design
reducing
experimental
costs.
Concurrently,
studies
revealed
intricate
between
active
site
protease.
The
amalgamation
screening
insights
underscores
emergence
potent
candidates
inhibitory
activity
against
SARS‐CoV‐2
M
pro
.
Additionally,
this
integrates
that
provide
valuable
into
SARS‐CoV‐2.
Quality in Sport,
Journal Year:
2025,
Volume and Issue:
37, P. 57009 - 57009
Published: Jan. 2, 2025
Introduction
and
Purpose
Theophylline,
used
for
over
a
century
in
asthma
COPD
treatment,
provides
anti-inflammatory
bronchodilatory
effects
via
phosphodiesterase
inhibition
adenosine
receptor
antagonism.
This
review
examines
its
mechanisms,
clinical
uses,
emerging
applications.
Materials
Methods
A
detailed
analysis
of
23
peer-reviewed
studies
from
scientific
databases,
including
PubMed,
focused
on
theophylline’s
pharmacokinetics,
pharmacodynamics,
safety,
novel
applications
areas
such
as
immunomodulation,
metabolic
disorders,
regenerative
medicine.
Results
Theophylline
shows
effects,
mitochondrial
support,
modulation
key
pathways
(e.g.,
PI3K/Akt,
NF-κB).
It
demonstrates
potential
COVID-19-related
ARDS,
promoting
muscle
regeneration,
treating
infertility.
However,
narrow
therapeutic
index
variability
pharmacokinetics
remain
significant
challenges.
Conclusion
remains
cost-effective
option
promise
broader
like
immunomodulation
disorders.
Further
research
advanced
drug
formulations
are
needed
to
enhance
safety
potential.
Environmental Science and Pollution Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
The
concentrations
of
135
pharmaceuticals
and
personal
care
products
(PPCPs)
were
determined
in
raw
influent,
final
effluent,
treated
biosolids
at
Canadian
wastewater
treatment
plants
(WWTPs)
to
evaluate
the
fate
PPCPs
through
liquid
solids
trains
typical
types
used
Canada
assess
changes
PPCP
matrices
between
2010-2013
2022.
dominant
influent
effluent
included
antidiabetic
metformin,
analgesics/anti-inflammatories
(acetaminophen,
ibuprofen,
2-hydroxy-ibuprofen),
caffeine
its
metabolite
(1,7
-
dimethylxanthine),
theophylline
(a
bronchodilator
caffeine),
an
insect
repellent
(N,N-diethyl-m-toluamide,
DEET),
iopamidol
contrast
media
for
X-rays).
differed
from
those
influent/effluent
antibiotics
(fluoroquinolones
doxycycline),
antidepressants
(sertraline,
citalopram,
amitriptyline),
a
preservative
antimicrobial
agent
(triclosan),
antihistamine
(diphenhydramine),
antifungal
(clotrimazole).
These
elevated
reflected
their
use
communities.
had
relatively
low
hydrophobicity
whereas
tended
be
more
hydrophobic,
or
electrostatic
forces
governed
sorption.
Higher
removal
was
generally
observed
WWTPs
that
biological
compared
primary
physical/chemical
treatment.
concentration
2022
influenced
by
risk
management
measures,
warnings,
development
new
pharmaceuticals,
COVID-19
pandemic,
other
factors.
time
trends
limited
information
available
on
Canada.
Continued
periodic
monitoring
is
recommended
fill
data
gaps
community
release
environment.
Journal of Dairy Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
The
rising
demand
for
nondairy
and
nonanimal
protein
sources
has
increased
plant-based
beverages
(PBB)
consumption.
However,
research
on
their
functional
properties,
metabolic
profile,
discrimination
potential
is
limited.
This
study
evaluated
the
of
proton
nuclear
magnetic
resonance
(1H
NMR)
spectroscopy
as
an
authentication
method
to
discriminate
milk
(cow
goat)
PBB
macro-groups,
including
soy-based,
fruit-based
(almond
coconut),
cereal-based
(rice
oat)
beverages,
based
profile.
A
total
22
(soy-,
almond-,
coconut-,
rice-,
oat-based
beverages),
4
cow
milk,
goat
cartons
were
analyzed
with
1H
NMR
obtain
Relevant
metabolites
macro-groups
identified
through
Mann-Whitney
U
test
partial
least
squares-discriminant
analysis.
Results
revealed
that
uridine
diphosphate,
glucose,
adenosine
key
identification
milk.
At
same
time,
choline
guanosine
emerged
important
markers
different
macro-group
detection.
In
addition,
lactose
played
a
significant
role
in
differentiating
from
PBB.
conclusion,
these
findings
represent
initial
step
toward
applying
nutritional
analysis
PBB,
opening
door
further
into
authenticity
profiling.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(2), P. 1019 - 1019
Published: Jan. 5, 2023
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
chronic
and
refractory
interstitial
lung
disease.
Although
there
are
two
approved
drugs
for
IPF,
they
were
not
able
to
completely
cure
the
Therefore,
development
of
new
required
effective
treatment
IPF.
In
this
study,
we
investigated
effect
theophylline,
which
has
long
been
used
asthma,
on
fibrosis.
The
administration
theophylline
attenuated
fibrotic
changes
tissues
improved
mechanical
functions
in
bleomycin
(BLM)-induced
Theophylline
suppressed
IL-17
production
through
inhibiting
cytokines
controlling
Th17
differentiation;
TGF-β,
IL-6,
IL-1β,
IL-23.
inhibition
IL-6
IL-1β
by
mediated
suppressing
BLM-induced
ROS
NF-κB
activation
epithelial
cells.
We
further
demonstrated
that
inhibited
TGF-β-induced
epithelial-to-mesenchymal
transition
cells
phosphorylation
Smad2/3
AKT.
inhibitory
effects
AKT
recapitulated
BLM-treated
tissues.
Taken
together,
these
results
prevents
differentiation
TGF-β
signaling.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(39), P. 28927 - 28942
Published: Jan. 1, 2024
Recent
progress
in
the
utilization
of
nanocarbon-based
materials,
such
as
graphene,
nanodiamond,
and
CNTs,
is
discussed
regarding
their
enhanced
performance
electrochemical
sensors
for
theophylline.
