International Journal of Drug Delivery Technology,
Journal Year:
2024,
Volume and Issue:
14(04), P. 1239 - 1247
Published: Dec. 24, 2024
The
press
coating
approach
has
been
employed
in
the
current
study;
this
system
involves
compressing
directly
of
both
core
as
well
coat.
procedure
is
same:
first,
we
make
tablet
containing
drug,
diluent,
binder,
Crospovidone
superdisintegrant
for
burst
release
after
lag
time,
glidant,
and
lubricant
an
8mm
die.
After
that,
get
Eudragit
S
100
polymer
different
ratios
divide
it
into
two
equal
parts,
subsequently
lower
half
inserted
a
cavity
10mm
die
followed
by
placed
middle,
other
portion
that
comprises
coat
filled
cavity.
Powder's
assessment
parameters
were
judged
to
be
within
appropriate
range.
Overall,
evaluation
results
press-coated
tablets
passed
acceptable
parameters.
Optimized
batch
F7
shows
99.07%
drug
release.
batches
are
further
evaluated
tests
like
FTIR,
DSC,
Stability
study
per
standard
ICH
guidelines.
From
all
result
conclude
concentration
increases
%
also
time.
acts
good
time
only
at
pH
7
means
colon
target
was
done
hence
successfully
pulsatile
delivery
performed.
Life,
Journal Year:
2022,
Volume and Issue:
12(9), P. 1384 - 1384
Published: Sept. 6, 2022
The
SARS-CoV-2
pandemic
has
confirmed
the
apocalyptic
predictions
that
virologists
have
been
making
for
several
decades.
challenge
world
is
facing
of
trying
to
find
a
possible
treatment,
and
viable
expedient
option
addressing
this
repurposing
drugs.
However,
in
some
cases,
although
these
drugs
are
approved
use
humans,
mechanisms
action
involved
unknown.
In
sense,
justify
its
therapeutic
application
new
disease,
it
ideal,
but
not
necessary,
know
basic
drug’s
biological
effects.
This
review
compiled
available
information
regarding
various
effects
attributed
Ivermectin.
controversy
over
treatment
COVID-19
demonstrated
by
report
considers
proposal
unfeasible
because
doses
proposed
achieve
effect
cannot
be
achieved.
due
urgent
need
an
exhaustive
impartial
necessary
order
integrate
knowledge
exists,
date,
through
which
may
helpful
defining
safe
schedules
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(6), P. 5884 - 5884
Published: March 20, 2023
Theophylline
is
a
drug
commonly
used
to
treat
asthma
due
its
anti-inflammatory
and
bronchodilatory
properties.
Testosterone
(TES)
has
been
suggested
reduce
the
severity
of
symptoms.
This
condition
affects
boys
more
than
girls
in
childhood,
this
ratio
reverses
at
puberty.
We
reported
that
guinea
pig
tracheal
tissue
chronic
exposure
TES
increases
expression
β2-adrenoreceptors
enhances
salbutamol-induced
K+
currents
(IK+).
Herein,
we
investigated
whether
upregulation
channels
can
enhance
relaxation
response
methylxanthines,
including
theophylline.
Chronic
incubation
tracheas
with
(40
nM,
48
h)
enhanced
induced
by
caffeine,
isobutylmethylxanthine,
theophylline,
an
effect
was
abolished
tetraethylammonium.
In
myocytes,
increased
theophylline-induced
IK+;
flutamide
reversed
effect.
The
increase
IK+
blocked
4-aminopyridine
~82%,
whereas
iberiotoxin
reduced
~17%.
Immunofluorescence
studies
showed
KV1.2
KV1.5
airway
smooth
muscle
(ASM).
conclusion,
ASM
promotes
theophylline
response.
Therefore,
gender
should
be
considered
when
prescribing
as
teenage
males
are
likely
respond
better
females.
International Journal of Drug Delivery Technology,
Journal Year:
2024,
Volume and Issue:
14(04), P. 1239 - 1247
Published: Dec. 24, 2024
The
press
coating
approach
has
been
employed
in
the
current
study;
this
system
involves
compressing
directly
of
both
core
as
well
coat.
procedure
is
same:
first,
we
make
tablet
containing
drug,
diluent,
binder,
Crospovidone
superdisintegrant
for
burst
release
after
lag
time,
glidant,
and
lubricant
an
8mm
die.
After
that,
get
Eudragit
S
100
polymer
different
ratios
divide
it
into
two
equal
parts,
subsequently
lower
half
inserted
a
cavity
10mm
die
followed
by
placed
middle,
other
portion
that
comprises
coat
filled
cavity.
Powder's
assessment
parameters
were
judged
to
be
within
appropriate
range.
Overall,
evaluation
results
press-coated
tablets
passed
acceptable
parameters.
Optimized
batch
F7
shows
99.07%
drug
release.
batches
are
further
evaluated
tests
like
FTIR,
DSC,
Stability
study
per
standard
ICH
guidelines.
From
all
result
conclude
concentration
increases
%
also
time.
acts
good
time
only
at
pH
7
means
colon
target
was
done
hence
successfully
pulsatile
delivery
performed.
